Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.
Type:
Grant
Filed:
August 14, 2020
Date of Patent:
July 18, 2023
Assignee:
Cellphire, Inc.
Inventors:
Keith Andrew Moskowitz, Braden Carl Ishler, William Matthew Dickerson, Narendra Nath Tandon, Amber Nicole Lee, Glen Michael Fitzpatrick
Abstract: The present invention relates to a liquid composition for use in the treatment of gastroesophageal reflux. The composition of the present invention comprises a mixture which comprises or, alternatively, consists of a combination of Aloe vera gel, hyaluronic acid and honey and, optionally, food or pharmaceutical grade additives and/or technological excipients. The composition of the present invention also relates to a medical device comprising a mixture which comprises or, alternatively, consists of a combination of Aloe vera gel, hyaluronic acid and honey and, optionally, food or pharmaceutical grade additives and/or technological excipients. Said composition or composition for a medical device being for use in the preventive and/or curative treatment of the symptoms associated with gastroesophageal reflux and the disease caused thereby, as well as for use in the preventive and/or curative treatment of gastroesophageal reflux disorders.
Abstract: The present invention relates to an edible product, which comprises a fibrous plant product and a plant extract applied thereto. Further, the invention relates to a corresponding method for producing said edible product and its use in at least one of food, food supplement, medicinal, cosmetic, well-being, nutraceutical or phytotherapeutical applications. The plants used may be all plants comprising one or more substances of interest for an edible product.
Type:
Grant
Filed:
August 20, 2020
Date of Patent:
June 6, 2023
Assignee:
Schweitzer-Mauduit International, Inc.
Inventors:
Philippe Ragot, Esther Pons, Bernard Mompon, Cedric Rousseau
Abstract: Provided herein are methods of inducing liver regeneration in a subject diagnosed with a liver disorder. The method comprises administering a Plasma Protein Fraction (PPF) to the subject. In certain embodiments, the PPF comprises between 83% and 95% albumin in relation to total proteins. The PPF can be produced from plasma obtained from young individuals, for example, humans 40 years of age or younger.
Abstract: A photobioreactor includes a first and a second container extending along a longitudinal direction; the second container extending inside the first container, so as to delimit a first channel between the first and the second containers; and forming a second channel inside the second container; a first passage means capable of allowing the circulation of a fluid between the first channel and the second channel; a second passage means capable of allowing the circulation of the fluid between the first channel and the second channel, disposed above the first passage means; at least one light source; a gas injection means, configured so as to inject gas in the form of bubbles into the second channel; the circulating fluid being able to be exposed to a light source.
Abstract: This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.
Type:
Grant
Filed:
June 24, 2021
Date of Patent:
April 25, 2023
Assignee:
EMORY UNIVERSITY
Inventors:
Cassandra L. Quave, James Lyles, Gina Porras-Brenes, Huaqiao Tang
Abstract: Single-serve containers for use in brewing a cannabis-based beverage are described, as are methods for preparing a single-serve container configured for receipt in a single-serve brewing machine. The method includes: adding a processed cannabis product to the single-serve container; adding, to the single-serve container, at least one of an extraction or flavoring agent; and sealing the single-serve container.
Type:
Grant
Filed:
July 31, 2020
Date of Patent:
April 18, 2023
Assignees:
CannTrust Inc., Single Dose Solutions Inc.
Inventors:
Ronald Stuart Benson, Peter Hobbes, Claudio Gemmiti, Ilana Deborah Platt
Abstract: A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.
Type:
Grant
Filed:
August 17, 2020
Date of Patent:
April 11, 2023
Assignee:
ENSION INC.
Inventors:
Ali Hussain, Patrick Cahalan, Linda Cahalan
Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising tianeptine, sakae naa, and optionally, at least one of kava, CDP Choline, and Alpha GPC; and providing the composition of matter in a liquid or solid form. The ingredient of tianeptine can be tianeptine sodium, tianeptine free acid, or both. Providing the composition of matter can include filling a container with the composition of matter.
Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising tianeptine, kava, and optionally, at least one of CDP Choline, and Alpha GPC; and providing the composition of matter in a liquid or solid form. The ingredient of tianeptine can be tianeptine sodium, tianeptine free acid, or both. Providing the composition of matter can include filling a container with the composition of matter.
Abstract: A composition includes a cannabinoid agent in a range of 0.005% to 1%, a terpene agent in a range of 0.005% to 1%, and a co-fermented herbal complex in a range of 5% to 40%. The cannabinoid agent can include CBD, CBN, CBG, or a combination thereof. The composition can further include ashwagandha.
Abstract: The invention relates to a polyphenolic extract of passion flower seeds, in particular Passiflora incarnata or Passiflora edulis seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof.
Type:
Grant
Filed:
April 23, 2021
Date of Patent:
March 7, 2023
Assignee:
LABORATOIRES EXPANSCIENCE
Inventors:
Sophie Leclere-Bienfait, Stéphanie Bredif
Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising tianeptine, CDP Choline, and optionally, Alpha GPC; and providing the composition of matter in a liquid or solid form. The ingredient of tianeptine can be tianeptine sodium, tianeptine free acid, or both. Providing the composition of matter can include filling a container with the composition of matter.
Abstract: A method of forming a dietary supplement can include steps of creating a composition of matter comprising tianeptine and GPC; and providing the composition of matter in a liquid or solid form. The ingredient of tianeptine can be tianeptine sodium, tianeptine free acid, or both. Providing the composition of matter can include filling a container with the composition of matter.
Abstract: A composition for the treatment of UTIs comprising: One of, a monosaccharide L-arabinose, L-frucose, D-mannose, L-rhamnose, L-xylose, lyxose or galactose; Extract from one of Boswellia serrata, Boswellia sacra or Boswellia carteri containing boswellic acids, terpenes and incensole acetate; Extract from the seeds of one of, Cucurbitaceae maxima, Cucurbitaceae pepo or Cucurbitaceae moschata; Turmeric extract; Green tea extract containing polyphenolic catechins; and, Piper nigrum.
Abstract: Provided is an A.C.C. extract from a combination of medicinal herbs, which are Phellodendron bark, Scutellaria baicalensis, Paeonia lactiflora Pall, Dictamnus dasycarpus Turcz, Anemarrhena asphodeloides, Alumen, Dryobalanops aromatica Gaertner, Mentha arvensis var. piperascens, Inula helenium, Syringa velutina var. kamibayashii, Corydalis incisa, Eclipta prostrata, Lonicera japonica, and Glycyrrhiza uralensis, and a composition having the same as an active ingredient. The A.C.C. extract of the present invention reduces production of TNF-? IL-1? and IL-6, thereby regulating the expression of iNOS and thus exhibiting an anti-inflammatory effect inhibiting NO production. Also clinically, the A.C.C. extract of the present invention is a substance that alleviates symptoms such as diaper rash and miliaria through anti-inflammatory and antimicrobial activitities and can be used as an effective anti-inflammatory agent.
Abstract: A method of making a binder for extruded, pelleted, or agglomerated animal feed. The binder is made by treating biomass such as soybean hull or lemon peels with an aqueous acidic solution for a time, at a temperature, and at a pH sufficient to yield a first mixture containing biomass solids and partially dissolved biomass; and mechanically treating the first mixture of step to yield a first mechanically treated mixture; and then incorporating the first mechanically treated mixture as a binder in an animal feed. Also described are animal feeds made using the binder.
Type:
Grant
Filed:
January 17, 2020
Date of Patent:
February 21, 2023
Assignees:
Auburn University, The United States of America, as Represented by the Secretary of Agriculture
Inventors:
Burak Aksoy, Zhihua Jiang, Mediha Aksoy, Benjamin Beck
Abstract: The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ?8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10?4, even down to 10?5. Also provided are diagnostic kits and methods for detecting MRD.
Type:
Grant
Filed:
October 30, 2020
Date of Patent:
February 7, 2023
Assignee:
Erasmus University Medical Center Rotterdam
Inventors:
Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes Van der Velden, Sebastian Böttcher, Anthonie Willem Langerak, Ester Mejst{hacek over (r)}íková, Tomasz Szczepański, Matthias Ritgen, Paulo Jorge Monteiro Da Silva Lucio
Abstract: Disclosed is a method for moisturizing skin in need thereof, the method comprising topically applying to the skin a composition that includes effective amounts of an extract from Echinacea purpurea, an extract from Silybum marianum, and glycerin, wherein topical application of the composition activates human cannabinoid receptor type 2 and inhibits fatty acid amide hydrolase activity in the skin and treats the skin.