Abstract: Disclosed are methods for treatment of humans exposed to bacterial endotoxin in circulation by administration of bactericidal/permeability-increasing (BPI) protein products. Serologically and hematologically verifiable alleviation of endotoxin mediated increases in circulating cytokines, fibrinolysis and coagulation factors and changes in lymphocyte counts are observed upon such treatment. Also observed is alleviation of endotoxin mediated decreases in systemic vascular resistance index (SVRI) and concomitant increases in cardiac index (CI).
Type:
Grant
Filed:
September 2, 1999
Date of Patent:
February 20, 2001
Assignee:
Xoma Corporation
Inventors:
Nadav Friedmann, Patrick J. Scannon, Sander J. H. van Deventer, Marijke A. M. von der Mohlen, Nancy Wedel
Abstract: This invention relates to a method for biodetection and identification of antibiotic susceptibility tested in bacteria by cerating spectrum against target cells and comparing them.