Abstract: This document describes methods and devices for treating ventricular fibrillation. For example, this document describes methods of performing electroporation of a ventricle and electroporation catheters. The methods can include inserting a distal end portion of a catheter into a ventricle of a heart of a patient, inflating a balloon coupled to the distal end portion of the catheter, occluding a valve of the heart associated with the ventricle with the balloon, injecting a fluid into the ventricle via an aperture defined by the distal end portion of the catheter, and generating an electrical current via an electrode on the distal end portion of the catheter.

Abstract: An electrosurgical instrument capable of performing both thermal ablation and electroporation in a minimally invasive manner. The instrument is dimensioned to fit within an instrument channel of an endoscope to enable non-percutaneous insertion. The instrument comprises a radiating tip mounted at a distal end of a coaxial transmission line to receive microwave EM energy from the coaxial transmission line and emit it as a field around the radiating tip. The instrument further comprises an auxiliary transmission line arranged to convey electromagnetic energy having an electroporation waveform to a microelectrode array mounted on the radiating tip. The electroporation waveform may be a radiofrequency or low frequency electromagnetic (EM) signal. The microelectrode array may comprise a plurality of nanoscale conductive electrode elements.

Abstract: A method is used to manufacture a surgical instrument. The surgical instrument includes a catheter and an end effector extending distally from the catheter. The method includes forming at least one electrode, sensor, or thermocouple onto the catheter or the end effector of the surgical instrument by etching or vapor depositing a three-dimensional structure onto a non-conductive material that is layered over a super elastic material.

Abstract: A medical apparatus includes a probe configured for insertion into a body of a patient and including a plurality of electrodes configured to contact tissue within the body. An electrical signal generator applies bipolar trains of pulses having a voltage amplitude of at least 200 V and having a duration of each of the bipolar pulses less than 20 ?s between at least one pair of the electrodes in contact with the tissue, thereby causing irreversible electroporation of the tissue between the at least one pair of the electrodes. One or more electrical sensors sense an energy dissipated between the at least one pair of the electrodes during the trains of the pulses. A controller controls electrical and temporal parameters of the trains of the pulses applied by the electrical signal generator, responsively to the one or more electrical sensors, so that the dissipated energy satisfies a predefined criterion.

Abstract: A balloon catheter includes a flexible outer cylinder shaft, a holding member connected to a proximal end portion of the outer cylinder shaft, a sealing member that maintains liquid tightness incorporated in the holding member, a flexible inner cylinder shaft, a tube having a Rockwell hardness of R 115 or more, a flexural modulus of 3.0 to 4.5 GPa, and a thickness of 0.06 to 0.12 mm, a push-in member connected to a proximal end portion of the inner cylinder shaft, a pull-out prevention member connected to the push-in member, and a balloon composed of an elastic material and connected to each of the distal end portion of the outer cylinder shaft and the proximal end portion of the inner cylinder shaft, wherein the tube is inserted over the inner cylinder shaft over an area thereof except for a connecting portion between the balloon and the inner cylinder shaft.

Abstract: Disclosed embodiments include an apparatus, a system and a method for shunting current between first and second electrodes to temporarily reduce current applied through first and second electrodes. In a nonlimiting embodiment, an illustrative apparatus includes first and second electrode couplings configured to electrically engage proximal ends of the first and second electrodes, respectively, the first and second electrodes each having a distal end configured to conduct electrical current generated by a switchable current source therebetween and through an electrically conductive target. A current inrush regulator is configured to temporarily shunt at least a portion of the electrical current generated by the switchable current source to temporarily reduce the electrical current passing between the distal ends of the first and second electrodes through the electrically conductive target.

Abstract: An antenna system for tissue ablation includes an energy transmission member, a conductive hollow coil member, and a fluid cooling system. The energy transmission member has an inner conductor, an outer conductor, and a dielectric layer between the inner and outer conductors. A portion of the dielectric layer extends distally of a distal end of the outer conductor. The conductive hollow coil member includes a member lumen within a length of the conductive hollow coil member. The conductive hollow coil member is coiled around the portion of the dielectric layer and is separate from the inner conductor. The conductive hollow coil member extends along an entire length of the outer conductor of the energy transmission member. The fluid cooling system is coupled to the conductive hollow coil member for providing a flow of a cooling fluid through the member lumen for cooling the conductive hollow coil member.

Abstract: An antenna system for tissue ablation includes an energy transmission member, an antenna body coupled to the energy transmission member, a fluid source, and a choke member comprising an integrally formed choke body and choke connector electrically coupled to the energy transmission member by the choke connector. The choke body defines an outermost portion of the choke member. The choke body has an axial length and the choke connector extends along a majority of the length of the choke body and contacts the choke body along the majority of the length. The choke connector is in direct contact with a fluid from the fluid source. The choke connector is disposed between the choke body and the energy transmission member. The choke connector forms a delivery path for the fluid between the choke body and the energy transmission member. The choke connector and the choke body are a continuous wire mesh.

Abstract: In a treatment system, an energy treatment instrument includes a pair of grasping pieces. An energy output source outputs electric energy to the energy treatment instrument, thereby applying treatment energy to a blood vessel grasped between the grasping pieces. A measurement section measures a blood pressure at a site related to the grasped blood vessel. A processor controls output of the electric energy from the energy output source based on a measurement result obtained by the measurement section, and thereby switches an actuation state of the energy treatment instrument between a first mode for coagulating the blood vessel and a second mode for coagulating the blood vessel target that is different from the first mode.

Abstract: The disclosure relates to a nozzle for a device for the dermo-cosmetic treatment of dark skin spots by cyto-selective cryotherapy comprising a spray jet supplied by a tank of pressurised liquified cryogenic gas. The nozzle comprises an upper ring for connecting to a shell, extended by a central body of which the side wall which narrows downwards has longitudinal openings and delimits a gas expansion chamber communicating with a frustoconical dispersal conduit arranged inside an end piece to be applied to the skin and opening to the outside through a discharge port.