Patents Examined by Alton D. Rollins
  • Patent number: 4551263
    Abstract: Use of compounds of the formula ##STR1## in which R.sup.1 designates hydrogen, an organic radical, the bonds R.sup.1 --N being C--N bonds, and, in the case in which m is 1, also acyl,R.sup.2 and R.sup.3 designate hydrogen, an organic radical, the bonds R.sup.2 --N and R.sup.3 --N being C--N bonds, and acyl, andm is an integer equal to the indicated valence of R.sup.1,the compounds of the formula I furthermore containing at least one acyl group, as activators for per compounds, bleaching agents and detergents containing these activators, and new triazolidine-3,5-diones.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: November 5, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl-Wolfgang Schellhammer, Ludwig Rottmaier, Rudolf Merten, Ulrich Schimmel
  • Patent number: 4549900
    Abstract: Substituted 1-azolyl-but-2-ones and -2-ols of the formula ##STR1## in which B is --CO-- or --CH(OH)--Az represents a 1,2,4-triazol-1-yl or -4-yl or imidazol-1-yl radical,R.sup.1 represents a hydrogen atom, an alkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted phenoxyalkyl or optionally substituted aralkyl radical,n is 0 or 1,R.sup.2 represents a cyano radical or a grouping of the general formula --X--R.sup.3 or --CO--NR.sup.4 R.sup.5, or, if n does not represent O at the same time as R.sup.1 represents a hydrogen atom and Az represents a 1,2,4-triazolyl radical,R.sup.2 also additionally represents an optionally substituted aryl or alkoxycarbonyl radical,and whereinX represents an oxygen or sulphur atom or an SO or SO.sub.2 group,R.sup.3 represents an alkyl, halogenoalkyl, optionally substituted aryl or optionally substituted aralkyl radical,R.sup.4 represents a hydrogen atom or an alkyl or optionally substituted aryl radical, andR.sup.
    Type: Grant
    Filed: April 4, 1983
    Date of Patent: October 29, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Hans-Ludwig Elbe, Udo Kraatz, Erik Regel, Paul-Ernst Frohberger, Wilhelm Brandes, Klaus Lurssen
  • Patent number: 4550173
    Abstract: Ditriazolylvinyl phenyl ketones of the formula I ##STR1## where R is halogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, trifluoromethyl, cyano, nitro, phenyl or phenoxy, and n is an integer from 0 to 5, and the two triazole rings can, as desired, be bonded in the 1-position or 4-position to the vinyl group, their preparation and their use as nitrification inhibitors.
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: October 29, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Alfred Ruland, Wolfgang Reuther, Ernst-Heinrich Pommer, Eberhard Ammermann
  • Patent number: 4549027
    Abstract: Compounds of formula ##STR1## where Az is 1-imidazolyl or 1-(1,2,4-triazolyl); R.sup.1 is aryl or optionally substituted alkyl; R.sup.2 and R.sup.3, which may be the same or different, are hydrogen or alkyl or, together with the carbon to which they are attached, form a 5 to 7 membered ring which may contain one or more oxygen atoms and which may be substituted, or when Az is 1-(1,2,4-triazolyl) can together with the carbon to which they attached form a carbonyl group; R.sup.4 is aryl, substituted alkyl or aryloxy, or when R.sup.2 and R.sup.3 form an oxygen containing ring, can be hydrogen or unsubstituted alkyl; and n is 0, 1 or 2; together with acid addition salts, quaternary ammonium salts and complexes of these compounds with metal salts have fungicidal and plant growth regulant activity.
    Type: Grant
    Filed: March 25, 1983
    Date of Patent: October 22, 1985
    Assignee: FBC Limited
    Inventor: Peter S. Gates
  • Patent number: 4548945
    Abstract: Substituted 1-hydroxyethyl-triazole derivatives of the formula ##STR1## in which R represents optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl,X represents the grouping --OCH.sub.2 --, --SCH.sub.2 --, --(CH.sub.2)p-- or --CH.dbd.CH--,Y represents the grouping --CO--Y.sup.1 or an acetal or ketal derivative thereof, or the grouping --C(Y.sup.1).dbd.N--OY.sup.2,Y.sup.1 represents hydrogen, alkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted phenyl or optionally substituted benzyl,Y.sup.2 represents hydrogen, alkyl, alkenyl, alkinyl, optionally substituted cycloalkyl or optionally substituted benzyl,Z represents halogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio andthe indices m and p represent 0, 1 or 2,or addition products thereof with acids or metal salts which possess fungicidal activity.
    Type: Grant
    Filed: September 21, 1983
    Date of Patent: October 22, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Jorg Stetter, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes, Hans Scheinpflug
  • Patent number: 4547500
    Abstract: A 2-methyl-8 (R) or (S) ergot peptide alkaloid in free base form or in pharmaceutically acceptable acid addition salt form is a useful anti-Parkinson agent, prolactin secretion inhibitor, anti-depressant, vigilance-increasing agent, and anti-migraine agent.
    Type: Grant
    Filed: May 10, 1983
    Date of Patent: October 15, 1985
    Assignee: Sandoz Ltd.
    Inventors: Georg Bolliger, Peter Stutz
  • Patent number: 4547214
    Abstract: Azole compounds having the general formula (I): ##STR1## wherein Y is --CH.dbd. or .dbd.N--, R.sup.1 is alkyl, cycloalkyl or optionally substituted phenyl and R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, alkyl, cycloalkyl, (e.g. cyclopropyl, cyclopentyl or cyclohexyl), optionally substituted phenyl or optionally substituted benzyl, or together form an alkylene bridging group; and acid addition salts, metal complexes, ester and ether derivatives of the hydroxy group and stereoisomers thereof. The compounds are useful as plant fungicides and for plant growth regulation.
    Type: Grant
    Filed: December 21, 1982
    Date of Patent: October 15, 1985
    Assignee: Imperial Chemical Industries PLC
    Inventors: Patrick J. Crowley, John C. Williams
  • Patent number: 4545935
    Abstract: Benzodiazepines having associated carbonyl lactam ring structure are synthesized from N-2-bromoethyl-5-alkoxy-2-pyrrolidinone and analine compounds, in the first ever such direct single step synthesis. The produced compounds are known biological active compounds having anti-anxiety activity similar to Valium.
    Type: Grant
    Filed: September 12, 1983
    Date of Patent: October 8, 1985
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: George A. Kraus
  • Patent number: 4543352
    Abstract: A class of naphthalene aminoalkylene ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions are disclosed.
    Type: Grant
    Filed: April 29, 1983
    Date of Patent: September 24, 1985
    Assignee: William H. Rorer, Inc.
    Inventors: Donald E. Kuhla, Henry F. Campbell, William L. Studt
  • Patent number: 4542145
    Abstract: Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides are inhibitors of thromboxane synthetase enzyme.
    Type: Grant
    Filed: February 29, 1984
    Date of Patent: September 17, 1985
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Jeffery B. Press, Andrew S. Tomcufcik
  • Patent number: 4540702
    Abstract: Disclosed herein novel compounds, 2-substituted-4-thiazolidones having anti-peptic ulcer activity, and methods for producing the same.
    Type: Grant
    Filed: August 30, 1982
    Date of Patent: September 10, 1985
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Takao Kawasaki, Tadashi Tsuchiya, Yoshiaki Osaka
  • Patent number: 4539160
    Abstract: Useful novel ketene O,O-acetals of the formula I ##STR1## where R.sup.1 is a tertiary alkyl radical of 4 to 6 carbon atoms or unsubstituted or halogen-substituted phenyl, R.sup.2 is hydrogen and R.sup.3 and R.sup.4 independently of one another are each phenyl which is unsubstituted or substituted by halogen, alkoxy, alkyl, phenyl, phenoxy, cyano, nitro or trifluoromethyl, their preparation and their use for the preparation of ketene O,N-acetals.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: September 3, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Alfred Ruland, Wolfgang Reuther
  • Patent number: 4537899
    Abstract: The invention relates to acylated 1,2,4-triazole derivatives of general formula I ##STR1## wherein R.sup.1 represents an unsubstituted phenyl group or a phenyl group substituted by one or more halogen atoms, lower alkyl, alkoxy, acyloxy, hydroxy, amino, azido, nitro, trifluoromethyl, lower alkylthio, alkylsulfinyl, or alkylsulfonyl group, andR.sup.2 stands for a C.sub.1-6 alkyl group or a phenyl lower alkyl group which is either unsubstituted or substituted in the aromatic nucleus by a halogen atom or a nitro group,and their pharmaceutically acceptable salts, and a process for preparing them. The new compounds according to the invention exhibit valuable antiviral activity.
    Type: Grant
    Filed: August 25, 1983
    Date of Patent: August 27, 1985
    Assignee: BIOGAL Gyogyszergyar
    Inventors: Istvan Horvath, Tibor Lang, Laszlo Pongo, Jozsef Reiter, Tamas Somorai, Geza Szilagyi, Lajos Toldy
  • Patent number: 4537905
    Abstract: Substituted oximinoacetanilides of the general formula ##STR1## in which R.sup.1 denotes an alkyl or alkoxy group or a halogen atom,R.sup.2 denotes a hydrogen or halogen atom or an alkyl or trifluoromethyl group,R.sup.3 denotes a hydrogen or halogen atom or an alkyl group,R.sup.4 denotes a hydrogen atom or a methyl group,R.sup.5 denotes an alkoxy, amino or --NH--CO--NH--R.sup.7 group,whereinR.sup.7 represents a hydrogen atom or an optionally cyano-, alkoxy- or alkoxycarbonyl-substituted alkyl group, or represents a cycloalkyl group, andR.sup.6 denotes various aliphatic or heterocyclic radicals, are new and find use as pest-combating agents, in particular as fungicides.
    Type: Grant
    Filed: January 27, 1983
    Date of Patent: August 27, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Brandes, Werner Daum
  • Patent number: 4536508
    Abstract: The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, which show pharmacological activity as selective histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: February 18, 1983
    Date of Patent: August 20, 1985
    Assignee: Glaxo Group Limited
    Inventors: John W. Clitherow, Barry J. Price, John Bradshaw, Michael Martin-Smith, John W. M. Mackinnon, Duncan B. Judd, Roger Hayes
  • Patent number: 4536509
    Abstract: Substituted ethanols of the general formula ##STR1## in which Ar.sub.1 is a carbocyclic or heterocyclic ring and Az is a triazolyl, benzimidazolyl, pyrazolyl or imidazolyl radical, are reacted with aryl hydrocarbons Ar.sub.2 --H, in which Ar.sub.2 has the same meaning as Ar.sub.1, in the presence of an acidic catalyst, to give 1,1-diaryl-2-azolylethanes.The substances, which, apart from the imidazolyl derivatives, are new, can be used as biocides, in particular fungicides.
    Type: Grant
    Filed: March 7, 1984
    Date of Patent: August 20, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ulrich Hertenstein, Hilmar Mildenberger, Burkhard Sachse, Peter Hartz
  • Patent number: 4535090
    Abstract: 3,5-diphenyl-1H-1,2,4-triazoles with contragestational activity of the following formula ##STR1## wherein R may be located on one or the other of the two adjacent nitrogen atoms and may represent hydrogen or a group R.sub.5 CO-- wherein R.sub.5 is an aliphatic saturated or unsaturated hydrocarbyl containing from 1 to 20 carbon atoms, R.sub.1, R.sub.2 and R.sub.3, each independently are selected from hydrogen, lower alkyl and lower alkoxy or R.sub.2 and R.sub.3 together may represent a methylenedioxy group, and R.sub.4 is an aliphatic saturated or unsaturated hydrocarbyl group of from 1 to 20 carbons, with the proviso that when R is hydrogen or an R.sub.5 CO-- group wherein R.sub.5 contains 4 or less carbon atoms, R.sub.4 must contain 5 or more carbons.These compounds have proven to be highly effective in terminating pregnancy in several animal species after a single parenteral injection.
    Type: Grant
    Filed: October 15, 1982
    Date of Patent: August 13, 1985
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Giulio Galliani, Amedeo Omodei-Sale, Pietro Consonni, Alessandro Assandri
  • Patent number: 4533662
    Abstract: Novel 2-acyl amino methyl-5-phenyl-1H-2,3-dihydro-1,4-benzo diazepine compounds of the following Formula I ##STR1## which have valuable pharmacological properties are provided. In said Formula I the acyl group --CO--R.sub.3 represents a benzoyl group or a phenyl alkanoyl group which may be unsubstituted or mono- or di-substituted in the phenyl ring. The substituent R.sub.1 in said compounds indicates lower alkyl, lower alkenyl, or cyclopropyl methyl, and the substituent R.sub.2 indicates hydrogen, lower alkyl, or lower alkenyl, while the substituent R.sub.6 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, lower alkylthio, nitro, trifluoro methyl, cyano, amino, mono- or di-lower alkyl amino, lower mono-alkanoyl amino, lower N-alkyl-N-alkanoyl amino, or lower alkanoyloxy, and the substituent R.sub.7 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy, whereby R.sub.6 and R.sub.
    Type: Grant
    Filed: December 14, 1981
    Date of Patent: August 6, 1985
    Assignee: Kali-Chemie Pharma GmbH
    Inventors: Horst Zeugner, Dietmar Roemer, Hans Liepmann, Wolfgang Milkowski
  • Patent number: 4532234
    Abstract: .alpha.-Neopentyl-phenethyltriazoles of the formula I ##STR1## where R.sup.1, m and A have the meanings given in the description, processes for their preparation, and their use for controlling fungi.
    Type: Grant
    Filed: September 7, 1983
    Date of Patent: July 30, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Ernst Buschmann, Guenter Schulz, Gerd Heilen, Ernst-Heinrich Pommer, Eberhard Ammermann
  • Patent number: 4530715
    Abstract: Cycloalkyl (.alpha.-triazolyl-.beta.-hydroxy)-ketones of the general formula ##STR1## in which R.sup.1 represents an optionally substituted cycloalkyl group, andR.sup.2 represents a halogenoalkyl, halogenoalkenyl or alkoxycarbonyl group,and their physiologically acceptable acid addition salts and metal salt complexes are new, are prepared as described and find use as fungicides and plant growth regulators.
    Type: Grant
    Filed: November 2, 1982
    Date of Patent: July 23, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Eckart Kranz, Karl H. Buchel, Udo Kraatz, Erik Regel, Wilhelm Brandes, Paul-Ernst Frohberger, Klaus Lurssen