Patents Examined by Amy C Bonaparte
  • Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
    Patent number: 11161873
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof. A process tor the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: November 2, 2021
    Assignees: FORSCHUNGSVERBUND BERLIN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • Cyclic process for producing taurine from monoethanolamine
    Patent number: 11161808
    Abstract: There is disclosed a cyclic process for producing taurine from monoethanolamine comprising the steps of: (a) reacting monoethanolamine with ammonium sulfate in the recycling mother liquor to yield monoethanolamine sulfate; (b) reacting the monoethanolamine sulfate with sulfuric acid to form 2-aminoethyl hydrogen sulfate ester; (c) subjecting the 2-aminoethyl hydrogen sulfate ester to a sulfonation reaction with ammonium sulfite to yield taurine and ammonium sulfate; (d) separating the taurine and the ammonium sulfate by means of solid-liquid separation; (e) removing the excess ammonium sulfite from the mother liquor to obtain an aqueous solution comprised of ammonium sulfate and (f) returning the aqueous solution to step (a) to complete the cyclic process.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: November 2, 2021
    Assignee: Vitaworks IP, LLC
    Inventor: Songzhou Hu
  • Pleuromulin acitretin ester with antibacterial activity and a method of preparing the same
    Patent number: 11155514
    Abstract: A compound with anti-drug resistant bacteria activity having the following formula (I) is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: December 19, 2020
    Date of Patent: October 26, 2021
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Bin Tian, Juan Li, Nan Hui, Guaiping Qiao, Liang Xin, Jingyi Li, Dan Yang, Han Li, Yanjun Li, Liang Qi, Wenbo Yao, Chengyuan Liang
  • Magnesium citrate glycinate co-salt
    Patent number: 11148990
    Abstract: A magnesium citrate glycinate co-salt has a formula of Mg2C8H9NO9—XH2O and a suggested structure of: The magnesium citrate glycinate co-salt has an apparent density of 1740 kg/m3 and is compressible in a range of compression pressures from approximately 50 MPa to approximately 150 MPa. The magnesium citrate glycinate co-salt is formed by combining citric acid and glycine in a 1:1 molar ratio to form an aqueous reaction mixture and neutralizing the aqueous reaction mixture with a magnesium source having a magnesium:ligand ratio of 1:1.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: October 19, 2021
    Assignee: Jost Chemical Co.
    Inventors: Joseph R. Hardimon, Kasey L. Morris
  • Processes for preparation of 4-aminoindane compounds and related aminoindane amides
    Patent number: 11148995
    Abstract: A process for preparation of 4-aminoindane compounds of a first formula, salts and enantiomers thereof including: a) hydrogenating a 1,2-dihydroquinoline of a second formula to give a corresponding tetrahydroquinoline of a third formula; b) acylating the tetrahydroquinoline of the third formula with a carboxylic acid derivative of a fourth formula to obtain a corresponding acyl derivative compound of a fifth formula; c) rearranging the acyl derivative compound of the fifth formula under acidic conditions so as to give an acyl indane compound of a sixth formula or an addition salt thereof; and d) hydrolysing the acyl group of the acyl indane compound of the sixth formula so as to obtain the 4-aminoindane derivatives of the first formula.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: October 19, 2021
    Assignee: STICHTING I-F PRODUCT COLLABORATION
    Inventors: Paolo Bellandi, Giampaolo Zanardi, Ravindra Vitthal Datar, Chockalingam Devarajan, Swamynathan Murali, Narayana Swamy
  • Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives
    Patent number: 11136290
    Abstract: Provided is a compound of Formula (I): wherein the variable groups are defined herein.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: October 5, 2021
    Assignee: The Liver Company Inc.
    Inventors: Julie Farand, Joshua A. Kaplan, Gregory Notte, Casey Lockwood Olen, Michael Sangi, David Sperandio
  • Method for producing methionine
    Patent number: 11111213
    Abstract: The present provides a method for producing methionine which is characterized by a crystallization step in which carbon dioxide is introduced into a reaction solution containing an alkali salt of methionine which is obtained by hydrolyzing 5-[2-(methylthio)ethyl] imidazoline-2,4-dione in the presence of an alkali compound, thereby precipitating the methionine, and further comprises a step of adding waste methionine to the reaction solution. The method of production of the present invention can improve a yield in the production of methionine.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: September 7, 2021
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yoshitaka Satoh, Norihito Omoto, Yoshiyuki Koizumi, Naoya Yamashiro, Ryousuke Katagami
  • Reduction of content of carboxylic acids and derivatives thereof in oleum, disulfuric acid or concentrated sulfuric acid
    Patent number: 11111201
    Abstract: The present invention concerns a process for the reduction of content of carboxylic acids and derivatives thereof in oleum, disulfuric acid or concentrated sulfuric acid. The invention further concerns a process for the manufacture of carboxylic acid anhydrides comprising the process for the reduction of content of carboxylic acids and derivatives thereof from oleum, disulfuric acid or concentrated sulfuric acid.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: September 7, 2021
    Assignee: Solvay SA
    Inventors: Jean-Marie Blaude, Benoit Gosselin, Alain Lambert, Matthias Marek, Harald Krueger, Jan Schostag, Miriam Heyd
  • Process for the decarboxylative ketonization of fatty acids or fatty acid derivatives
    Patent number: 11111190
    Abstract: Process (P) for the decarboxylative ketonization of fatty acids, fatty acid derivatives or mixtures thereof in the liquid phase with metal compounds as catalyst wherein the fatty acids, fatty acid derivatives or mixtures thereof are added sequentially. Downstream chemistry can be realized starting from internal ketones obtained by process (P), especially in order to design and develop new surfactants.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: September 7, 2021
    Assignee: RHODIA OPERATIONS
    Inventors: Olivier Back, Rémy Leroy, Philippe Marion
  • Oxysterols and methods of use thereof
    Patent number: 11111266
    Abstract: Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R5, R6, and RG are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: September 7, 2021
    Assignee: SAGE THERAPEUTICS, INC.
    Inventors: Francesco G. Salituro, Albert Jean Robichaud, Gabriel Martinez Botella, Boyd L. Harrison, Andrew Griffin
  • Process for the preparation of safinamide mesylate intermediate
    Patent number: 11111208
    Abstract: The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: September 7, 2021
    Assignee: RK PHARMA SOLUTIONS LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannappan, Rajesh A Patel, Daxeshkumar Prakashbhai Patel
  • Renewable polymers and resins and methods of making the same
    Patent number: 11104763
    Abstract: The present disclosure relates to methods for producing polymers and resins, the method including a first reacting of at least a first diamine with a first carbonate-containing compound and a second carbonate-containing compound to produce at least one of the polymer or the resin, where the first reacting is according to each of R1, R2, R3, and R4 include at least one of a hydrogen atom, a methyl group, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain, and R comprises at least one of a carbon atom, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: August 31, 2021
    Assignee: Alliance for Sustainable Energy, LLC
    Inventors: Tao Dong, Lieve M. L. Laurens, Philip T. Pienkos, Paris Fabian Spinelli
  • Method of purifying 1,5-diaminopentane
    Patent number: 11098004
    Abstract: Provided is a method of refining 1,5-diaminopentane, the method including preparing a fermented broth including a carbonate salt of 1,5-diaminopentane; preparing a first composition by heating the fermented broth; preparing a second composition and an evaporation residue by evaporating the first composition; preparing a third composition by adding water to the evaporation residue and evaporating the water; and recovering 1,5-diaminopentane by distilling the second composition and the third composition.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: August 24, 2021
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Seok Hyun Kang, Won Sik Gwak, Chang Yub Oh, Jin Tae Hong
  • Englerin derivatives for treatment of cancer
    Patent number: 11098054
    Abstract: Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: August 24, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Sciences, Fundacio Institut Catala D'Investigacio Quimica, University of Delaware, University of Leeds, Universitat Rovira I Virgili
    Inventors: John A. Beutler, Antonio Echavarren, William Chain, David Beech, Zhenhua Wu, Jean-Simon Suppo, Fernando Bravo, Hussein Rubaiy
  • Method for preparation of N-acetyl cysteine amide and derivatives thereof
    Patent number: 11091433
    Abstract: The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R?)-3,3?-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: August 17, 2021
    Assignee: Nacuity Pharmaceutials, Inc.
    Inventors: G. Michael Wall, Doug Johnson, Anja Rubenstein, Rodney Tucker, Josh Bolger
  • Heat-sensitive recording material
    Patent number: 11084307
    Abstract: The invention relates to a compound of the formula (I) Ar(NHSO2Ar1)l(SO2NHAr1)m(NHC(O)NHAr2)n (I), wherein l and m independently of one another are 0, 1, 2, 3, and/or 4 and the sum of l+m is equal to or more than 1, n is 2, 3, 4, or 5, Ar is a benzol group which is substituted (l+m+n) times, Ar1 is an unsubstituted or substituted aromatic group, and Ar2 is an unsubstituted or substituted phenyl group or a benzoyl group. The invention also relates to a heat-sensitive recording material comprising a carrier substrate and a heat-sensitive color-forming layer which contains at least one color former and at least said color developer.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: August 10, 2021
    Assignee: PAPIERFABRIK AUGUST KOEHLER SE
    Inventors: Michael Horn, Timo Stalling, Kerstin Zieringer
  • Cinnamyl alcohol acitretin ester with antioxidant activity and a method of preparing the same
    Patent number: 11084775
    Abstract: A compound having the formula (I): (I) is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: August 10, 2021
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Bin Tian, Juan Li, Gennian Mao, Limei Wang, Mudan Xu, Xingke Ju, Han Li, Yanjun Li, Qiao Zeng, Chengyuan Liang
  • Esterification unit for producing crude methyl methacrylate, esterification process using said unit and plant comprising said unit
    Patent number: 11084774
    Abstract: The invention relates to an esterification unit (150) and esterification process for producing crude methyl methacrylate (MMA) from methacrylamide (MAM), which enable particularly to improve the yield, meaning that the organics spent acids are low; and at the same time, providing crude MMA with rather good quality, meaning that MMA concentration in crude MMA is rather high and preferably from 50 wt % to 80 wt %. According to the invention, the esterification unit comprises esterification reactors (1, . . . , 5 (or 6) set up in a serial way so that there is a counter current flow between gaseous phase and liquid phase, the liquid phase flowing from first reactor (1) of the series to last reactor (5 (or 6)), and the gaseous phase flowing from reactor to first reactor (1).
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: August 10, 2021
    Inventors: Yves Bernardin, Romain Billon, Xavier Marcarian, Florent Vallet
  • Chiral phosphoramidimidates and derivatives thereof
    Patent number: 11084834
    Abstract: The present invention relates to chiral phosphoramidimidates, their salts and metal complexes as well as derivatives thereof and their use as catalysts.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: August 10, 2021
    Assignee: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Benjamin List, Philip Stephan Joseph Kaib, Lucas Schreyer, Sunggi Lee, Roberta Properzi, Luping Liu
  • Phosphorodiamidates and other phosphorus derivatives of fingolimod and related S1P receptor modulators
    Patent number: 11078221
    Abstract: Compounds of general formula (I): (Formula I)) wherein R1, Q, R3, R4, R5, R6, R7 and Ar1 are as defined herein are inhibitors of class I histone deacetylases and are of use in the treatment of lysosomal storage disorders, especially Niemann-Pick type C disease, as well as other lysosomal storage disorders, defective autophagy, accumulation of free cholesterol and mycobacterial diseases.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: August 3, 2021
    Assignee: UNIVERSITY COLLEGE CARDIFF CONSULTANTS LTD
    Inventors: Emyr Lloyd-Evans, Fabrizio Pertusati, Edward James, Emily Maguire, Christopher McGuigan