Patents Examined by Anand U Desai
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Patent number: 11965192Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.Type: GrantFiled: November 30, 2021Date of Patent: April 23, 2024Assignee: Codexis, Inc.Inventors: Jovana Nazor, Vesna Mitchell, David Elgart, Katrina W. Lexa, Nikki Dellas, Robert Kevin Orr, Oscar Alvizo, Ravi David Garcia, Judy Victoria Antonio Viduya, Courtney Dianne Moffett
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Patent number: 11952412Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface of the exosome.Type: GrantFiled: April 3, 2022Date of Patent: April 9, 2024Assignee: SHIFTBIOInventors: Eun-ee Koh, Eun Jung Lee, Yoo Soo Yang, In-San Kim
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Patent number: 11946089Abstract: The present invention provides for a mechanism to reduce glycerol production and increase nitrogen utilization and ethanol production of recombinant microorganisms. One aspect of this invention relates to strains of S. cerevisiae with reduced glycerol productivity that get a kinetic benefit from higher nitrogen concentration without sacrificing ethanol yield. A second aspect of the invention relates to metabolic modifications resulting in altered transport and/or intracellular metabolism of nitrogen sources present in corn mash.Type: GrantFiled: February 4, 2022Date of Patent: April 2, 2024Assignee: Lallemand Hungary Liquidity Management LLCInventors: Aaron Argyros, Trisha Barrett
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Patent number: 11939612Abstract: The invention provides a process for preparing sphingolipids, compositions comprising sphingolipids and further components, and for the use of the compositions.Type: GrantFiled: October 8, 2021Date of Patent: March 26, 2024Assignee: Evonik Operations GmbHInventors: Marrit Friederike Eckstein, Monica Desiree van Logchem, Hans Henning Wenk, Annika Schrader, Ursula Maczkiewitz, Claudia Hierath, Sunay Karacocuk, Andreas Seifert
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Patent number: 11898185Abstract: The present invention relates to a method for producing fucosylated oligosaccharides by using a recombinant prokaryotic host cell that is cultivated on a gluconeogenic substrate, as well as to the host cell and its use. The host cell is genetically modified in that the activity of a fructose-6-phosphate converting enzyme is abolished or lowered, and the transport of the produced fucosylated oligosaccharide through the cell membrane is facilitated by an exogenous transport protein.Type: GrantFiled: October 24, 2017Date of Patent: February 13, 2024Assignee: Chr Hansen HMO GmbHInventors: Stefan Jennewein, Dirk Wartenberg, Katja Parschat
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Patent number: 11884566Abstract: Metal bioremediation and metal mining strategies can include compositions and methods.Type: GrantFiled: September 3, 2020Date of Patent: January 30, 2024Assignee: Massachusetts Institute of TechnologyInventors: George Le-Le Sun, Angela M. Belcher
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Patent number: 11858972Abstract: The present invention relates to new peptidic compounds, more specifically to micropeptides derived from lncRNAs implicated in cancer and cellular plasticity. It also relates to the use of the said micropeptides in the treatment of proliferative diseases, more specifically in the treatment of cancer.Type: GrantFiled: March 15, 2019Date of Patent: January 2, 2024Assignee: Fundació Privada Institut d'Investigació Oncològica de Vall HebronInventors: Maria Abad Méndez, Olga Boix Sánchez, Emanuela Greco, Iñaki Merino Valverde
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Patent number: 11858971Abstract: This invention relates to elastomeric protein and elastomeric protein production. In particular, the invention is directed to elastomeric protein sequences, including methods and compositions for production of elastomeric protein sequences, such as expression constructs, and host cells, and including compositions generated from the elastomeric protein sequences.Type: GrantFiled: March 31, 2021Date of Patent: January 2, 2024Assignee: BOLT THREADS, INC.Inventors: Joshua Kittleson, Michael Lee, David N. Breslauer, Daniel M. Widmaier
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Patent number: 11834689Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.Type: GrantFiled: March 9, 2021Date of Patent: December 5, 2023Assignees: THE SCRIPPS RESEARCH INSTITUTE, SYNTHORX, INC.Inventors: Jerod Ptacin, Carolina Caffaro, Hans Aerni, Yorke Zhang, Emil C. Fischer, Aaron W. Feldman, Vivian T. Dien, Floyd E. Romesberg
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Patent number: 11826366Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.Type: GrantFiled: October 31, 2021Date of Patent: November 28, 2023Assignee: MOREHOUSE SCHOOL OF MEDICINEInventors: Zhigang Xiong, Roger P. Simon
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Patent number: 11827887Abstract: Disclosed is a method for producing an alkaline phosphatase fusion antibody, comprising: culturing a cell comprising an expression vector comprising a gene encoding alkaline phosphatase derived from bovine small intestine or Shewanella bacterium and a gene encoding an antibody in a medium comprising a zinc ion, and acquiring an alkaline phosphatase fusion antibody expressed by the cell.Type: GrantFiled: May 27, 2021Date of Patent: November 28, 2023Assignee: SYSMEX CORPORATIONInventors: Hirotaka Abo, Nobuyuki Ide
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Patent number: 11819534Abstract: The disclosure provides molecules for use in compositions, medicaments and methods for the treatment or prevention of RSV infections, its symptoms and associated pathologies and potentially infections caused or contributed to by viral pathogens which do not bind or do not primarily bind sialic acid containing receptors during pathogenesis. Specifically, the disclosure is based on the finding that molecules with affinity for (or an ability to bind to) sialic acid (and in particular sialoglycoconjugates) on cell surfaces (these including sialic acid containing glycoproteins and cell surface sialic acid receptors), find utility in the treatment and/or prevention of symptoms, infections, diseases and/or conditions associated with respiratory syncytial vims (RSV).Type: GrantFiled: February 27, 2019Date of Patent: November 21, 2023Assignee: Pneumagen LtdInventors: Helen Connaris, Lei Yang, Jane Alexandra Potter
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Patent number: 11814448Abstract: The present disclosure provides an artificially synthesized peptide fragment that can efficiently introduce a foreign substance of interest from outside a eukaryotic cell into at least the cytoplasm of the cell. The present disclosure also provides a method for using the peptide fragment. The herein disclosed peptide fragment is a peptide fragment for introducing a foreign substance of interest from outside a eukaryotic cell into at least the cytoplasm of the cell, and is provided with a repeat sequence in which the VVRSLVK amino acid sequence (SEQ ID NO: 1) is repeated at least two or more times. By using a construct that has the peptide fragment and the foreign substance of interest bonded to the N-terminal side and/or C-terminal side of the peptide fragment, the foreign substance of interest can be efficiently introduced from outside a eukaryotic cell into at least the cytoplasm of the cell.Type: GrantFiled: November 12, 2021Date of Patent: November 14, 2023Assignee: TOAGOSEI CO., LTD.Inventors: Nahoko Baileykobayashi, Tetsuhiko Yoshida
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Patent number: 11807890Abstract: The present disclosure relates to methods for producing oxygenated terpenoids, and preparation of compositions and formulations thereof. Polynucleotides, derivative enzymes, and host cells for use in such methods are also provided.Type: GrantFiled: November 22, 2021Date of Patent: November 7, 2023Assignees: GIVAUDAN SA, MANUS BIO INC.Inventors: Ajikumar Parayil Kumaran, Chin Giaw Lim, Liwei Li, Souvik Ghosh, Christopher Pirie, Anthony Qualley, Geoff Marshall-Hill, Martin Preininger
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Patent number: 11802140Abstract: A system, including methods and compositions, for treatment of ischemia.Type: GrantFiled: February 11, 2022Date of Patent: October 31, 2023Assignee: MOREHOUSE SCHOOL OF MEDICINEInventors: Roger P. Simon, Zhigang Xiong
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Patent number: 11802141Abstract: Beta-sheet forming polypeptides at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-24 are disclosed, together with their use and methods for designing beta-sheet forming polypeptides.Type: GrantFiled: October 23, 2020Date of Patent: October 31, 2023Assignee: UNIVERSITY OF WASHINGTONInventors: Tamuka Chidyausiku, Enrique Marcos, Lucas Nivon, Gustav Oberdorfer, David Baker, Lauren Carter
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Patent number: 11788067Abstract: The present invention relates to a fusion protein consisting of a scFv linked to a horseradish peroxidase enzyme or to an alkaline phosphatase enzyme by a peptide linker. The fusion protein also includes a histidine tag and optionally an endoplasmic reticulum retention signal. The invention also includes nucleic acids encoding the fusion protein, expression vectors containing the nucleic acids, plant cells transformed with the expression vectors and methods of producing the fusion proteins of the invention.Type: GrantFiled: May 23, 2017Date of Patent: October 17, 2023Assignee: University of Cape TownInventors: Ann Elizabeth Meyers, Edward Peter Rybicki, Inga Isabel Hitzeroth
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Patent number: 11788104Abstract: The invention relates to an integrated process for alcohol production from lignocellulosic material.Type: GrantFiled: April 8, 2021Date of Patent: October 17, 2023Assignee: Versalis S.p.A.Inventor: Johannes Petrus Smits
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Patent number: 11766461Abstract: Provided are nucleic acids that include a promoter, where the promoter is operable in a Bacteroides cell and is operably linked to a heterologous nucleotide sequence of interest. Also provided are nucleic acids that include a promoter (operable in a prokaryotic cell such as a Bacteroides cell) operably linked to a sequence encoding a synthetic ribosomal binding site (RBS). Also provided are fusion proteins (and nucleic acids encoding them) in which a secreted Bacteroides polypeptide is fused to a heterologous polypeptide of interest. Also provided are prokaryotic cells (e.g., E. coli, a Bacteroides cell, and the like) that include one more nucleic acids such as those described above. Also provided are methods of expression in a prokaryotic cell, methods of detectably labeling a Bacteroides cell in an animal's gut, and methods of delivering a protein to an individual's gut.Type: GrantFiled: April 18, 2017Date of Patent: September 26, 2023Assignee: The Board of Trustees of the Stanford JuniorInventors: Justin L. Sonnenburg, Weston R. Whitaker, Elizabeth Stanley
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Patent number: 11759427Abstract: The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm?1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm?1.Type: GrantFiled: January 21, 2021Date of Patent: September 19, 2023Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Keith P. Johnston, Joshua Engstrom, Robert O. Williams, III