Patents Examined by Andrea S Grossman
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Patent number: 10823677Abstract: A method of determining the concentration of at least one analyte in a plurality of samples by sequentially subjecting each sample to an analysis cycle comprises contacting the sample or a sample-derived solution with a sensor surface supporting a species capable of specifically binding the analyte or an analyte-binding species, detecting the amount of binding to the sensor surface, and regenerating the sensor surface to prepare it for the next analytical cycle, and based on the detected binding to the sensor surface determining the concentration of analyte in each sample using virtual calibration data calculated for each analysis cycle from real calibration data obtained by contacting the solid phase with samples containing known concentrations of analyte.Type: GrantFiled: June 1, 2009Date of Patent: November 3, 2020Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Peter Borg, Asa Frostell-Karlsson, Markku Hamalainen
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Patent number: 10825548Abstract: A system and method for sensing and analyzing antibody blocking interactions is described. A biosensor can be used to identify interactions between antibodies to generate interaction profiles for the antibodies. A processor can be used to assign the antibodies to one or more bins, with the antibodies sharing a common interaction profile assigned to a common bin, and each antibody only being assigned to one bin. The antibodies can be represented by displaying nodes grouped together for antibodies in a common bin. Connections between the nodes can be displayed, representing interactions between the antibodies.Type: GrantFiled: December 2, 2014Date of Patent: November 3, 2020Assignees: Carterra, Inc., Rinat Neuroscience Corp.Inventors: Adam Miles, Joshua W. Eckman, Yasmina Abdiche
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Patent number: 10816561Abstract: Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.Type: GrantFiled: January 7, 2019Date of Patent: October 27, 2020Assignee: JANSSEN PHARMACEUTICA NVInventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Bart M. Remmerie, Rhys Salter, Ronghui Lin
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Patent number: 10809261Abstract: The present invention pertains to the field of cancer prediction. Specifically, it relates to a method for predicting the risk of recurrence of bladder cancer in a subject after treatment of bladder cancer comprising the steps of determining the amount of at least one biomarker selected from the biomarkers shown in Table, and comparing the amount of said at least one biomarker with a reference amount for said at least one biomarker, whereby the risk of recurrence of bladder cancer is to be predicted. The present invention also contemplates a method for identifying a subject being in need of a further bladder cancer therapy. Encompassed are, furthermore, diagnostic devices and kits for carrying out said methods.Type: GrantFiled: May 8, 2017Date of Patent: October 20, 2020Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, INSTITUT CURIEInventors: Christoph Schröder, Harish Srinivasan, Jörg Hoheisel, François Radvanyi
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Patent number: 10792018Abstract: Methods are disclosed for non-invasively obtaining fetal cells from a pregnant female. The methods include placing an absorbent medium in an interlabial or intravaginal space or adjacent to the perineum at the vaginal opening of the pregnant female, and collecting vaginal fluid comprising cells in the absorbent medium while the absorbent medium is interlabial or intravaginal space or adjacent to the perineum at the vaginal opening. The absorbent medium is removed and cells are isolated from the absorbent medium to obtain the fetal cells. The fetal cells can be, for example, somatic cells, embroyic stem cells, fetal stem cells or trophoblast cells.Type: GrantFiled: August 13, 2018Date of Patent: October 6, 2020Assignee: Preprogen LLCInventors: William H. Fleming, Shalom Z. Hirschman
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Patent number: 10793644Abstract: Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.Type: GrantFiled: September 1, 2017Date of Patent: October 6, 2020Assignee: JANSSEN PHARMACEUTICA NVInventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
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Patent number: 10774154Abstract: The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.Type: GrantFiled: December 19, 2017Date of Patent: September 15, 2020Assignee: MORPHOSYS AGInventors: Stefan Haertle, Christian Frisch, Achim Knappik
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Patent number: 10752872Abstract: In one aspect the present invention relates to a system 100 for automated extraction of multi-cellular physiological parameters. The system 100 comprises a morphogenesis module 160 for growing a plurality of cells, a monitoring unit 110 for monitoring the plurality of cells, a controller 140 for controlling the morphogenesis module 160 and the monitoring unit 110 to grow the plurality of cells and analyse the growth of the plurality of cells in order to determine the multi-cellular physiological parameters, the controller (140) further comprising a process modelling unit (146) for determining inter-cellular interactions in response to various process conditions. The multi-cellular physiological parameters may provide an optimised protocol for growing various tissue types. A further aspect of the present invention provides a method 200 for automated extraction of multi-cellular physiological parameters.Type: GrantFiled: March 18, 2011Date of Patent: August 25, 2020Assignee: GE Healthcare UK LimitedInventors: Yuriy Alexandrov, Albert Francis Santos
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Patent number: 10739340Abstract: Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.Type: GrantFiled: April 27, 2018Date of Patent: August 11, 2020Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Ryan C. Bailey, Matthew S. Luchansky, Abraham J. Qavi, Jared T. Kindt
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Patent number: 10739262Abstract: A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.Type: GrantFiled: April 7, 2017Date of Patent: August 11, 2020Assignee: HYCOR Biomedical, LLCInventors: Mark David Van Cleve, Elaine Grace Taine, Douglas John Canfield, Stephanie TuVi Ortega, Taylor Addison Reid
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Patent number: 10732110Abstract: A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.Type: GrantFiled: April 7, 2017Date of Patent: August 4, 2020Assignee: HYCOR Biomedical, LLCInventors: Mark David Van Cleve, Elaine Grace Taine, Douglas John Canfield, Stephanie TuVi Ortega, Taylor Addison Reid
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Patent number: 10732111Abstract: A quantitative method for performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.Type: GrantFiled: April 7, 2017Date of Patent: August 4, 2020Assignee: HYCOR Biomedical, LLCInventors: Mark David Van Cleve, Taylor Addison Reid, Linda Marie Trondle, Victoria Hung, Yi Luo, Dennis Edwin Rieger, Evan Phillip McMenamy, Nanditha Raghavan, Morkoah Blay Reliford, Douglas John Canfield, Elaine Grace Taine, Edsel Lawrence Noche Sinson, Scott William Vande Wetering, Teri Taylor, Travis Knox, Fran Zylo Cuaresma Jacalne, James Weston, Jennifer Bao-Guey Chan, Stephanie TuVi Ortega, Rachel Sarah Schell, Ronald Norman Diamond, Steve Michael Gann, Eric Darnell Hall, Tae Ho Hwang, John Lewis Morton, Anatoly Moskalev, Marinela Gombosev Stack, Bruce Alan Sargeant, Michelle Fredrika Forshager, Vanessa Camille Chua, Kylie Wilson
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Patent number: 10732176Abstract: The present invention relates to a method for identification of specific target proteins in a protein sample following a detection procedure, such as a Western blotting procedure, wherein the membrane is probed with at least two primary antibodies directed against the same and/or different epitopes of the same target protein, and wherein specific binding to the target protein in a sample is differentiated from unspecific binding to the target protein by comparing the resulting sample patterns, such as bands or spot patterns, with each other. In a further step signals from the true target proteins are enhanced while signals resulting from unspecific binding are diminished.Type: GrantFiled: June 27, 2012Date of Patent: August 4, 2020Assignee: GE Healthcare Bio-Sciences ABInventors: Lennart Bjorkesten, Sofia Edlund, Asa Hagner-McWhirter
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Patent number: 10725052Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.Type: GrantFiled: March 2, 2017Date of Patent: July 28, 2020Assignee: IDEXX LABORATORIES, INC.Inventors: Mahalakshmi Yerramilli, Giosi Farace, John J. Quinn, Murthy V. S. N. Yerramilli
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Patent number: 10718777Abstract: The present invention relates to methods of visualizing targets in histological samples, e.g. biopsy samples, wherein the methods comprise staining of the sample with (i) one or more target specific immunochemical stains, and (ii) a histological stain for specific tissue components e.g. iron, mucins glycogen, amyloid, nucleic acids, etc., e.g. hematoxilyn and/or eosin stains or the like, that is used to enhance contrast in the microscopic image of a tissue sample, highlight morphologic structures in the sample for viewing, define and examine tissues, cell populations, or organelles within individual cells. Methods may further comprise evaluation of expression of one or more targets in the sample. The disclosed methods are useful for medical diagnostics.Type: GrantFiled: December 6, 2011Date of Patent: July 21, 2020Assignee: AGILENT TECHNOLOGIES, INC.Inventor: Jesper Lohse
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Patent number: 10690686Abstract: Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.Type: GrantFiled: May 8, 2017Date of Patent: June 23, 2020Assignee: JANSSEN PHARMACEUTICA NVInventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
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Patent number: 10662459Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.Type: GrantFiled: February 21, 2013Date of Patent: May 26, 2020Assignee: Laboratory Corporation of America HoldingsInventors: Jeff Albrecht, Andrew J. Conrad
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Patent number: 10656149Abstract: This disclosure provides, among other things, a method of sample analysis, that comprises: (a) binding target analytes to capture agents that are attached to a surface of a plate, wherein the plate comprises (i) a sensing amplification layer comprises nanostructures that enhance signals and (ii) the capture agents are attached to said sensing amplification layer; (b) reading the plate with a reading device to produce an image of signals that represent individual binding events; and (c) identifying and counting individual binding events in an area of the image, thereby providing an estimate of the amount of one or more analytes in the sample. A system for performing the method is also provided.Type: GrantFiled: March 14, 2014Date of Patent: May 19, 2020Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Stephen Y. Chou, Liang-Cheng Zhou
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Patent number: 10648970Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.Type: GrantFiled: November 8, 2012Date of Patent: May 12, 2020Assignee: AGILENT TECHNOLOGIES, INC.Inventors: Jesper Lohse, Kristian Jensen, Rikke Malene Krusenst Jerna-Hafstrom, Kirsten Damgaard Hoff, Lars Christian Jacobsen
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Patent number: 10627401Abstract: The present invention provides methods, compositions, and kits associated with analyzing, enriching, and/or isolating a biomarker or analyte in a biological sample. In one aspect, for example, a method for determining a concentration of a biomarker in a biological sample can include binding any unbound biomarker with an antibody specific for the biomarker to form antibody-bound biomarker, enriching the antibody-bound biomarker and any endogenous autoantibody-bound biomarker to form an enriched fraction, identifying the biomarker in the enriched fraction, and determining the concentration of the biomarker in the biological sample. In one aspect, the concentration of the biomarker is derived from initially unbound biomarker and autoantibody-bound biomarker in the biological sample.Type: GrantFiled: September 21, 2015Date of Patent: April 21, 2020Assignee: University of Utah Research FoundationInventors: Mark M. Kushnir, Alan L. Rockwood, A. Wayne Meikle