Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein a, b, c, d, G1, G2, L1, L2, R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8 and X are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, nanoparticles comprising the compounds and methods for their use and preparation are also provided.

Abstract: A personal care composition is provided, comprising: a vehicle; a cosmetically acceptable oil; and a cationic polymer comprising structural units of acrylamide monomer; structural units of N,N-dimethyl acrylamide monomer; and structural units of monoethylenically unsaturated monocationic monomer; wherein the cationic polymer comprises <10 mol % structural units of multiethylenically unsaturated cationic monomer; wherein the cationic polymer comprises <30 wt % structural units of ester containing monomers; wherein the cationic polymer comprises <1 mol % structural units of ethylenically unsaturated monomers containing a moiety selected from the group consisting of epoxy, anhydride, imide, lactone, carboxylic acid, sulfonic acid and isocyanate; wherein the cationic polymer comprises <0.1 mol % structural units of a reactive siloxane; and wherein the personal care composition comprises <0.05 wt % water soluble, organic, ampholytic polymer conditioning agent.

Abstract: A personal care cosmetic composition; its method of manufacture; and its method of use are disclosed.

Abstract: The present disclosure relates to a method for preparing a biodegradable and eco-friendly organic-inorganic hybrid microcapsule having few toxic substances with high versatility and economical efficiency by using a pickering emulsion method with a specific outer wall reinforcing material, a reactive material, and inorganic nanoparticles, and allowing polymerization of the outer wall reinforcing material and the reactive material to proceed at the interface. Specifically, the organic-inorganic hybrid microcapsule can stably support an active ingredient and then effectively express its activity by pressure, and exhibit a characteristic of gradually releasing the active ingredient at room temperature.

Abstract: The present disclosure provides a method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties and the hydrogel composition prepared by the method. Related application products of the hydrogel composition of the present disclosure include wound dressings, drug carriers, three-dimensional cellular scaffolds, soluble microspheres, and cell capture and release systems, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has good in vitro and in vivo stability and high biocompatibility, and is non-toxic. The hydrogel composition can be removed and replaced by washing with metal chelating aqueous solution at low temperature.

Abstract: The present disclosure relates to methods for preparing a hydrophilic composition including intimately mixing a silicone component including at least one polysiloxane and a polymer component, and to hydrophobic polymer compositions prepared thereby. One aspect of the disclosure provides an article having a major exterior surface, the article comprising an intimate mixture of a silicone component including at least one polysiloxane; and a polymer component including at least one hydrophilic polymer having a water-absorption capacity of at least 50 wt. %; wherein the silicone component and the polymer component are present in the mixture in a dry weight ratio within the range of 99.9:0.1 to 30:70. In certain desirable embodiments as otherwise described herein, the intimate mixture is disposed at an exterior surface of the article, e.g., at the major exterior surface of the article.

Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.

Abstract: A curable composition apportioned between at least one Part A and at least one Part B, the Parts sealed within barrier means in manner to prevent contamination thereof, the composition comprising: (i) one or more alkenyl-containing prepolymers having at least one alkenyl moiety per molecule, (ii) one or more SiH-containing prepolymers having at least one SiH unit per molecule, and additionally: (iii) a catalyst for curing by addition of alkenyl-containing prepolymer (i) to SiH-containing prepolymer (ii), wherein the at least one Part A and at least one Part B are provided within or upon at least two respective receptacles or supports and are adapted to be dispensed or released therefrom in cooperative manner facilitating intimate contact and curing thereof, wherein the receptacle(s) or support(s) for at least one of Part A and Part B is thermally stable at elevated temperature of 123 C for a period in excess of 18 hours, methods for preparing the composition, methods for sterilisation thereof, medical and

Abstract: One aspect of the invention provides a slurry comprising: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible surfactant. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; a biocompatible surfactant; and a foam comprising a plurality of gas bubbles. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible excipient. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a lipolytic agent.

Abstract: An implantable delivery device and method for utilizing the device to delivery a bioactive agent to a subject in need thereof is described. The device includes a pattern of structures fabricated on a surface of the device to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The device may be located adjacent tissue such as an endovascular implant or a perivascular implant, and may deliver the bioactive agent without triggering an immune or foreign body response to the bioactive agent.

Abstract: A method of making infused non-demineralized cartilage fibers employs the following steps: cutting or shaving cartilage tissue into cartilage long aspect ratio fibers, washing the fibers, and infusing the fibers with a supernatant of biologic material or a polyampholyte cryoprotectant or a combination of both to create infused fibers.

Abstract: Described herein are compositions comprising, a polymer; a non-physiological solution; and a visualization agent; wherein the polymer is soluble in the non-physiological solution and insoluble at physiological conditions. Methods of preparing the compositions are disclosed as well as methods of using these compositions to treat vascular conditions.

Abstract: Provided herein are compositions and methods for treating respiratory and pulmonary vascular disease. In particular, provided herein are spray dried simvastatin for delivery to the lung.

Abstract: A formulated oral prebiotic edible composition includes a free amino acid containing ingredient comprising L-arginine, the L-arginine comprising free individual molecules of L-arginine, the free individual molecules of L-arginine L present at a concentration of greater than about 0.1 weight percent, a carrier, and a sugar comprising at least one of a monosaccharide and disaccharide, at least two distinct live lactic acid probiotics, wherein one is a lactic acid producing bacterium, and one is a lactic acid fermenting bacterium, wherein the composition is in configuration suitable to be maintained substantively dissolved within the oral cavity, and wherein the composition is in an effective amount to selectively promote stimulation of a first oral microbiota to produce an excretion product, and wherein a second oral microbiota metabolizes the excretion product to treat the respiratory allergic condition and/or an oral and/or sinus infection.

Abstract: A method for making a therapeutic agent-eluting temporary medical implant. In various embodiments, the method includes normalizing a quantity of therapeutic agent particles to attain a size distribution of 0.1-100 microns; creating a non-solid blend of a polymer and at least one therapeutic agent including between about 0.1 and about 20.0 weight percent of at least one therapeutic agent to a total weight of the non-solid blend; vat polymerizing the non-solid polymer blend to produce a therapeutic-eluting implant including at least one therapeutic agent homogenously distributed throughout; and cleaning and curing the therapeutic agent-eluting implant to produce a final device that supports physiologic loads when implanted within the patient. In at least one embodiment, the method includes of using a therapeutic agent that includes of one or more antibiotic, antifungal, analgesic, and/or chemotherapeutic.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: The invention relates to a lubricating member for a razor cartridge having a lubricating member comprising a carboxymethyl cellulose.

Abstract: A medical device adapted for contact with a vessel or cavity in the body including a tubular portion is provided. The device has an external surface including an external substance that is at least one of a coating or an impregnation, comprising alexidine in an amount that is both anti thrombogenically effective and anti microbially effective. The device also has an internal surface including an internal substance that is at least one of a coating or an impregnation, comprising alexidine in an amount that is both anti thrombogenically effective and anti microbially effective.

Abstract: The present invention provides prodrugs and methods of use thereof.

Abstract: A cosmetic or dermocosmetic agent consisting of: galactomannans having molecular weights between 5 and 630 kDa, and crosslinked sulfated galactans having molecular weights between 7 and 3000 kDa. Methods of using the agent, including for skin tensing and rejuvenation.