Patents Examined by Anjali Ajit Hirani
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Patent number: 11447427Abstract: Methods for controlling pathogenic plant nematodes using organic soil amendments applied to soil and/or plants, methods of improving the performance and/or improving the health of a ruminant animal and methods of decreasing nematodes in a ruminant animal are described.Type: GrantFiled: July 13, 2018Date of Patent: September 20, 2022Assignee: HOLGANIX, LLCInventors: David Stark, Robert Neidermyer
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Patent number: 11434467Abstract: Disclosed is an Aspergillus niger seed continuous culture method, comprising the steps of: (1) at a startup stage, Aspergillus niger spores are inoculated into a seed culture medium to obtain a seed liquid; (2) at a seed continuous culture stage, continuous dispersion treatment is performed on the seed liquid obtained in step (1), continuous culture is performed on the seed liquid obtained by dispersion, and meanwhile, a fresh seed feed medium is replenished; and (3) at a stop stage, the replenishment of the fresh seed feed medium and the dispersion treatment are stopped, continuous culture is performed to obtain a seed liquid, and then the seed liquid is transferred into the fermentation medium for fermentation culture. The method according to the present invention makes breakthrough to solve problems that multi-cellular filamentous bacteria grow slowly and mycelium pellets are easy to lose in continuous culture, thus fully achieving seed continuous culture.Type: GrantFiled: December 24, 2018Date of Patent: September 6, 2022Assignees: Jiangsu Guoxin Union Energy Co., Ltd, JIANGNAN UNIVERSITYInventors: Guiyang Shi, Zhijie Hu, Youran Li, Xiaodong Jiang, Sai Jin, Fuxin Sun, Cheng Zhang, Dongjiao Zhou, Jiawei Lu, Maodong Miao, Zihao Fan
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Patent number: 11421196Abstract: Disclosed herein is a high-density distributed three-dimensional electrode device and an associated electroporation method. The method includes applying an electric pulse of a first polarity to a first group of electrodes while simultaneously applying an electrical pulse of a second polarity to a remaining group of electrodes, and then applying an electric pulse of the first polarity on a second group of electrodes while simultaneously applying an electric pulse of the second polarity to the remaining groups of electrodes. The electrodes receiving the electric pulse of the first polarity being surrounded by the electrodes receiving the electric pulse of the second polarity, and the first polarity and the second polarity are opposite.Type: GrantFiled: November 15, 2018Date of Patent: August 23, 2022Assignee: ETTA BIOTECH CO., LTD.Inventor: Edward Dai
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Patent number: 11413335Abstract: The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent, agitating and shearing said suspension in a high shear mixing reactor, adding water to allow particles to agglomerate, allowing the non-aqueous solvent to evaporate, drying and sieving the composition; and thus forming the powdered hemostatic composition.Type: GrantFiled: February 13, 2018Date of Patent: August 16, 2022Assignees: Guangzhou Bioseal Biotech Co. Ltd, Ethicon, Inc.Inventors: Shuang Chen, Yufu Li, Aibin Yu, Jianping Yu
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Patent number: 11376284Abstract: The invention provides compositions comprising bacterial strains for treating and preventing central nervous system disorders and conditions.Type: GrantFiled: November 22, 2019Date of Patent: July 5, 2022Assignee: 4D Pharma Research LimitedInventors: Helene Savignac, Imke Elisabeth Mulder, Alexander James Stevenson, Ted Dinan, John Cryan
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Patent number: 11357183Abstract: Pelagic, surface floating, macroalga, Sargassum is harvested at large scale from a free-roaming farm floating freely on the ocean surface, monitored and tracked with GPS drifters and contained only by naturally occurring circular currents known as eddies or gyres, without aquaculture equipment. The farming technique occurs in open ocean through the utilization of system design and technology. Satellite imagery is interpreted to locate naturally occurring Sargassum aggregations or mats. Harvest vessel(s) travel to an identified mat, where only a portion of the natural mat is harvested as starter culture for a free-roaming farm. Cuttings are left behind to become new plants to restore the “mother mat” for no net loss of habitat and for migration for cohabitating organisms. The remainder of the biomass is transported to the identified free-roaming farm site which is in a suitable Eddie. GPS drifters are adhered with seedlings until the crop is ready for harvest.Type: GrantFiled: January 15, 2019Date of Patent: June 14, 2022Inventor: Alyson Myers
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Patent number: 11345879Abstract: A functionally graded material is formed by pipetting individual micro-or-nano-litter droplets with a variety of materials including multi-nanostructured material (nanowires, carbon nanotubes, enzymes, multi-element and/or multi-color, multi-biomolecules) and UV polymerization of the flat hydrogel meniscus surface formed at the carrier fluid interface. After step-by-step droplet pipetting and subsequent layer-by-layer UV polymerization via a digital mask, the complete fabricated part without supporting layers is taken out of the carrier fluid while the un-cured micro-litter residue is conveniently suctioned out of the carrier fluid.Type: GrantFiled: November 17, 2015Date of Patent: May 31, 2022Assignee: Lawrence Livermore National Security, LLCInventors: Xiaoyu Zheng, Joshua R. Deotte
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Patent number: 11327068Abstract: A method and apparatus for determining a presence of a microorganism in a sample is provided. The method includes storing electrophysiological and/or impedance signatures of a plurality of microorganisms in a memory of a processor. The method also includes obtaining a sample and generating an electrophysiological and/or impedance signature of the sample. The electrophysiological and/or impedance signature of the sample is compared with the electrophysiological and/or impedance signatures in the memory. A presence of one of the plurality of microorganisms in the sample is then identified based on a correlation between the electrophysiological and/or impedance signature of the sample and the electrophysiological and/or impedance signature of the one of the plurality of microorganisms. A method is also provided for determining a growth stage of a microorganism in a sample.Type: GrantFiled: April 12, 2018Date of Patent: May 10, 2022Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Parthiban Rajasekaran, Swaminathan Rajaraman
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Patent number: 11326192Abstract: The present invention relates to a variant of oleaginous yeast of the species Trichosporon oleaginosus characterized by mutations affecting cell wall synthesis that change the morphology thereof with respect to the wild-type strain of the same species. In particular, thanks to said mutations, cell aggregates are formed which, with respect to the wild-type strain of the same species, lower the viscosity of the culture broth, are more easily separable therefrom and thus make their recovery easier. Said variant of oleaginous yeast of the species Trichosporon oleaginosus is also characterized by yields of oleaginous cellular biomass and intracellular accumulation of lipids that are similar or even higher than those of the wild-type strain. Further, the present invention relates to a process for the production of lipids through said variant of oleaginous yeast of the species Trichosporon oleaginosus.Type: GrantFiled: July 17, 2018Date of Patent: May 10, 2022Assignee: Versalis S.p.A.Inventors: Valentina Rodighiero, Giuliana Franzosi, Concetta Compagno, Claudia Capusoni
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Patent number: 11306344Abstract: Single dye fluorescent staining (with a membrane-associated dye such as FM 1-43 or FM 4-64) and the combination of differences in both intensity and spectral emission discriminate live from inactivated/dead bacteria and provides for rapid and accurate detection of live bacteria in mixed populations.Type: GrantFiled: January 9, 2016Date of Patent: April 19, 2022Assignee: TACOUNT EXACT LTD.Inventor: Eran Zahavy
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Patent number: 11300567Abstract: There are provided, inter alia, methods for reacting an enzyme and its substrate, methods for purifying a protein and an enzyme reactor and its use thereof.Type: GrantFiled: August 24, 2016Date of Patent: April 12, 2022Assignees: The Regents of the University of CaliforniaInventors: Gregory A. Weiss, Joshua Britton, Colin L. Raston
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Patent number: 11285178Abstract: Fertilized egg isolate, methods for preparing the fertilized egg isolate and uses thereof for treating mental health disorders and disease or conditions mediated by or associated with one or more glutamate receptors or by the neurokinin 2 (NK2) receptor.Type: GrantFiled: October 15, 2018Date of Patent: March 29, 2022Assignee: United Paragon Associates, Inc.Inventors: Jerald Bain, Hao Chen, Joel Sadavoy, Arthur David Weissman
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Patent number: 11266762Abstract: Methods for producing a fibrin matrix comprising a fusion peptide are described herein. In some embodiments, the method includes providing three different components, including a first component containing fibrinogen or a fibrinogen precursor and optionally, transglutaminase or a transglutaminase precursor, a second component containing thrombin or a thrombin precursor, and a third component containing a fusion peptide. In these embodiments, neither the first component nor the second component includes the fusion peptide. In some embodiments, the first or second components are premixed with the third component. The first, second and third components are mixed to form a fibrin matrix comprising a covalently linked fusion peptide. The mixing is carried out in a time frame of not more than 5 days. A kit for producing the fibrin matrix comprising a covalently linked fusion peptide is also described herein.Type: GrantFiled: March 6, 2019Date of Patent: March 8, 2022Assignee: KUROS BIOSURGERY AGInventors: Lorenz Vogt, Alistair Simpson Irvine, Philippe Paul Saudan
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Patent number: 11260087Abstract: Provided is a novel Lactobacillus acidophilus YTI strain (deposition number: KCCM 11808P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus acidophilus comprising the novel strain.Type: GrantFiled: August 11, 2017Date of Patent: March 1, 2022Assignee: KOREA FOOD RESEARCH INSTITUTEInventors: Young-Do Nam, Yun-Tai Kim, Hee Soon Shin, So-Young Lee, Jae-Goo Kim, Eun-Yeong Lim, Eun-Ji Song
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Patent number: 11242549Abstract: The present invention relates to a method for obtaining a high titer of enzyme mixture comprising cellulases, hemicellulases and ?-glucosidases in reutilization of waste water generated during hot water extraction of lignocellulosic biomass or biorefinery waste water using Penicillium funiculosum MRJ-16 mutant strain. The cellulose or lignocellulosic biomass used in the fermentation process is selected from the group consisting of rice straw, wheat straw, corn stover, cotton stalk or a combination thereof. The enzyme mixture obtained by the present process is used for the saccharification of acid pretreated lignocellulosic biomass.Type: GrantFiled: February 8, 2020Date of Patent: February 8, 2022Assignees: INDIAN OIL CORPORATION LIMITED, DEPARTMENT OF BIOTECHNOLOGYInventors: Mukund Adsul, Simranjeet Kaur Sandhu, Reeta Rani Singhania, Ravi Prakash Gupta, Suresh Kumar Puri, Sankara Sri Venkata Ramakumar, Anshu Shankar Mathur, Deepak Kumar Tuli
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Patent number: 11224626Abstract: The subject matter of the instant invention relates to methods of enhancing harvesting of phages against a targeted host bacteria, as well as methods of identifying phages likely to have an enhanced propensity to infect and kill an infectious pathogenic bacteria in vivo, from samples comprising phages. The invention also relates to phage libraries, pharmaceutical compositions, methods of treatment, and phage-based diagnostic methods and methods of detecting bacteria related thereto.Type: GrantFiled: August 24, 2018Date of Patent: January 18, 2022Assignees: The United States of America as Represented by the Secretary of the Navy, The United States of America as Represented by the Secretary of the ArmyInventors: James M Regeimbal, Stuart D Tyner
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Patent number: 11169145Abstract: Among the various aspects of the present disclosure is the provision of a method of detection, treatment, and monitoring of cardiovascular disease or a foot wound by detection of a novel biomarker, Fatty Acid Synthase (FAS). Briefly, therefore, the present disclosure is directed to methods that allow for improved, noninvasive, and reliable diagnosis of these conditions, particularly in subjects suffering from Type 2 Diabetes (T2D).Type: GrantFiled: May 1, 2018Date of Patent: November 9, 2021Assignee: Washington UniversityInventors: Mohamed Zayed, Clay Semenkovich
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Patent number: 11123385Abstract: Provided are a functional food or pharmaceutical composition or a method for preventing, alleviating or treating hyperphosphatemia and chronic kidney disease and treating chronic kidney disease using the composition comprising Lactobacillus sp. KCCM 11826P having excellent phosphorus-absorbing ability.Type: GrantFiled: January 26, 2017Date of Patent: September 21, 2021Assignees: Korea Food Research Institute, Catholic Kwandong University Industry FoundationInventors: Hyo Jin Kim, Hae Won Jang, Young-Wook Chin, Woo Kyung Kang, Sung Jin Moon
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Patent number: 11123379Abstract: The invention provides compositions comprising bacterial strains for treating and preventing a neurodegenerative disorder.Type: GrantFiled: December 13, 2019Date of Patent: September 21, 2021Assignee: 4D Pharma Research LimitedInventors: Imke Elisabeth Mulder, Anna Ettorre, Suaad Ahmed, Parthena Fotiadou, Samantha Yuille, Helene Savignac
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Patent number: 11118197Abstract: In one aspect, the present invention provides methods for preparing a fermentation product. The methods include pre-treating a mixture of biomass and ionic liquid, wherein the ionic liquid comprises a choline cation and the biomass comprises polysaccharide and lignin. The methods further include forming hydrolysates from the introduction of glycoside hydrolase to the pre-treated mixture at conditions sufficient to produce a sugar composition mixture for fermentation steps. The present invention provides methods for loading biomass mixtures in a batch-fed process, wherein the biomass slurries can be loaded into water or a concentrated sugar composition for hydrolysate production. The methods can be performed in a one-pot process, wherein the ionic liquids are present in the mixtures throughout each step. Aspects of the invention provide compositions of sugar composition mixtures and fermentation product mixtures.Type: GrantFiled: November 21, 2016Date of Patent: September 14, 2021Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Feng Xu, Blake Simmons, Seema Singh