Patents Examined by Ann Montgomery
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Patent number: 11740232Abstract: The present invention relates to antigen arrays and methods for the detection of immunoglobulins specific for any one of the antigens of the array in a biological sample. Specifically, the present invention relates to antigen arrays comprising groups of antigen-coated beads fixed on a solid support. Further encompassed herein are cartridges, kits and an apparatus comprising the antigen array and methods of using same.Type: GrantFiled: March 30, 2017Date of Patent: August 29, 2023Assignee: Macroarray Diagnostics GmbHInventors: Christian Harwanegg, Georg Mitterer
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Patent number: 11740162Abstract: The present disclosure relates to a gel-phase patch that performs a function of assisting in staining during a staining process such as a process of coming into contact with a specimen such as blood to perform a staining function of staining the specimen, a process of fixing the specimen, or a process of forming an optimal pH at a specimen stained by a staining sample. According to an aspect of the present disclosure, a contact-type staining patch includes a staining solution that reacts with a specimen and a gel receptor provided as a gel matrix of a mesh structure in which a pore that accommodates the staining solution is formed and the mesh structure prevents the staining solution in the pore from leaking or degenerating, and having a contact surface that comes into contact with the specimen to transfer some of the staining solution to the specimen.Type: GrantFiled: May 20, 2019Date of Patent: August 29, 2023Assignee: NOUL CO., LTD.Inventors: Dongyoung Lee, Kyunghwan Kim, Youngmin Shin, Hyunjeong Yang, Chanyang Lim
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Patent number: 11713483Abstract: Provided herein are products and methods for detecting analytes using polymers that bind to such analytes and thereby undergo a conformational change or contribute to a newly formed complex.Type: GrantFiled: February 8, 2017Date of Patent: August 1, 2023Assignee: Children's Medical Center CorporationInventors: Wesley Philip Wong, Clinton H. Hansen
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Patent number: 11666907Abstract: This document provides methods, devices, and systems for detecting the presence, absence, or amount of one or more analytes. For example, this document provides methods for using graphene-based sensors to detect one or more analytes (e.g., proteins, nucleic acids, intact cells, intact viruses, intact microorganisms, and/or chemicals).Type: GrantFiled: September 28, 2018Date of Patent: June 6, 2023Assignee: GRIP Molecular Technologies, Inc.Inventors: John Lalonde, Bruce Edgar Batten
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Patent number: 11639933Abstract: Methods of detecting a target in a sample are provided. Kits for performing the methods described herein are also provided.Type: GrantFiled: September 25, 2018Date of Patent: May 2, 2023Assignee: Bio-Rad Laboratories, Inc.Inventors: Boaz Gildor, Dalia Shezifi
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Patent number: 11635378Abstract: An analyte-sensitive substance is provided that has an optical property related to the concentration of an analyte. The analyte-sensitive substance includes an ionophore or other substance configured to provide a local pH, within the analyte-sensitive substance, that is related to the concentration of the analyte proximate the analyte-sensitive substance. The analyte-sensitive substance further includes a pH-sensitive fluorophore that increases or decreases its intrinsic fluorescence intensity with the local pH across a specified range of pH values. The analyte-sensitive substance further includes a pH-sensitive quencher configured to increase the slope of the change of fluorescence intensity of the pH-sensitive fluorophore across the specified range of pH values. The analyte-sensitive substance may further include an ionic additive configured to adjust the local pH such that the specified range of pH values corresponds to a range of analyte concentration values of interest.Type: GrantFiled: October 19, 2020Date of Patent: April 25, 2023Assignee: Verily Life Sciences LLCInventors: Timothy Tordella Ruckh, Zhan Wang
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Patent number: 11619631Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.Type: GrantFiled: April 11, 2019Date of Patent: April 4, 2023Assignee: Quanterix CorporationInventors: David C. Duffy, David M. Rissin, David R. Walt, David Fournier, Cheuk Kan
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Patent number: 11612891Abstract: A filter film includes a through-hole and a recessed portion having a size capable of capturing one particle, in which the recessed portion is open to one face of the filter film, the through-hole in the one face has a shape or a size such that the one particle is not capable of passing through the through-hole, and the through-hole and the recessed portion are disposed close to each other.Type: GrantFiled: April 17, 2019Date of Patent: March 28, 2023Assignee: TOKYO OHKA KOGYO CO., LTD.Inventors: Yasuo Suzuki, Atsushi Murota, Takashi Ohsaka, Toshiyuki Ogata
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Patent number: 11585737Abstract: Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element may support a microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins.Type: GrantFiled: June 29, 2020Date of Patent: February 21, 2023Inventor: Lee H. Angros
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Patent number: 11567071Abstract: The disclosed devices for lateral flow testing may include a receptacle for receiving bodily fluids from a patient that has a predetermined fluid volume for application to one or more lateral flow test strips. A test strip holder may be positioned to receive the predetermined fluid volume of the bodily fluids from the receptacle. Various other components, devices, and methods are also disclosed.Type: GrantFiled: October 6, 2021Date of Patent: January 31, 2023Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.Inventors: Eric David Bergman, Daniel Lewis Sloat, Jonathan Fitzmaurice Leclerc, Rachel Lauren Bartels
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Patent number: 11561221Abstract: Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described.Type: GrantFiled: May 2, 2019Date of Patent: January 24, 2023Assignee: TRUSTEES OF BOSTON UNIVERSITYInventors: Derin Sevenler, M. Selim Ünlü
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Patent number: 11506592Abstract: This disclosure provides an impedance cytometer which includes a carrier that can be attached to a living being, with a biosensor mounted thereto. The bio sensor includes a microfluidic flow channel, formed in the carrier, and an impedance circuit. The microfluidic flow channel accommodates passage of a particle therethrough. The impedance circuit, connected to the microfluidic flow channel, includes a signal generator that produces a high-frequency drive signal applied to the flow channel to produce a biosensor output signal having high-frequency variation resulting from the drive signal and low-frequency variation resulting from impedance variation within the flow channel during the particle's passage. A lock-in amplifier is disposed to (i) amplify the bio sensor output signal, (ii) mix the amplified signal with the drive signal, and (iii) frequency-filter the mixed, amplified signal to output an impedance signal representing the low-frequency impedance variation resulting from the passage of the particle.Type: GrantFiled: October 17, 2019Date of Patent: November 22, 2022Assignee: Rutgers, the State University of New JerseyInventors: Mehdi Javanmard, Abbas Furniturewalla
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Patent number: 11499968Abstract: A nanoparticle measurement device includes a timing signal generation unit, a low-frequency component extraction unit, a low-frequency component calculation unit, a threshold correction unit, and a measurement unit. The timing signal generation unit generates timing signals. The low-frequency component extraction unit extracts low-frequency components according to the timing signals. The low-frequency component calculation unit calculates an interpolated low-frequency component in accordance with the low-frequency components. The threshold correction unit sets a corrected threshold in accordance with the interpolated low-frequency component. The measurement unit extracts and counts nanoparticle pulse signals from a light reception signal according to the timing signals and the corrected threshold.Type: GrantFiled: February 25, 2019Date of Patent: November 15, 2022Assignee: JVC KENWOOD CORPORATIONInventors: Shigehiko Iwama, Masahiro Yamamoto, Atsushi Saito
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Patent number: 11402376Abstract: In one embodiment, the present invention includes a system for detecting a target analyte which includes a microfluidic device having least one microfluidic channel with a binding surface positioned in the microfluidic channel with further include a first electrode and a second electrode. The system may further include a detector and a voltage supply. Also included is a method to detect a target analyte using a described microfluidics device, introducing solution with a target analyte to a binding surface, and binding the target analyte to the binding surface by applying an electrical potential between the first and second electrodes during at least a portion of the binding step, which enhances the rate of binding of the target analyte molecules to the binding molecules. The method then includes the steps of detecting a reporter molecule which corresponds to the amount of the bound target analyte molecules, which correlates with the amount of target analyte in the original sample.Type: GrantFiled: March 21, 2019Date of Patent: August 2, 2022Assignee: UNIVERSITY OF WYOMINGInventors: Debashis Dutta, Michael Taylor, Ravichander Rao Peesara
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Patent number: 11391746Abstract: A testing device for identifying an antigen or antibody within a biofluid sample including: a substrate having a hydrophilic surface thereon; the surface including a collection zone, and at least one detection zone extending therefrom; wherein the biofluid sample can be mixed with a specific antigen or antibody, and deposited on the collection zone and transferred by capillary action to the detection zone; the antigen or antibody in the biofluid sample reacting with an appropriate said antibody or antigen thereby resulting in a visual indication within the detection zone.Type: GrantFiled: June 7, 2016Date of Patent: July 19, 2022Assignee: MONASH UNIVERSITYInventors: Gil Garnier, Wei Shen, Mohidus Samad Khan, Xu Li, George Thouas
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Patent number: 11366107Abstract: The present invention describes a method of performing immunoassay measurements on whole blood samples for biomarker quantification. These tests are routinely performed on serum or plasma separated from whole blood samples. Prior art also involves application of complex multi-component assays or methods using insoluble particles for these measurements. A solution capable of working on whole blood samples, offering advantages in assay simplicity, cost-effectiveness and shortened measurement times was desired. The present invention solves these issues using simple immunoturbidimetry for whole blood samples without relying on particle enhancement of the reaction. To achieve this goal the agglutination reaction between antibodies and antigens is performed, measured and evaluated according to the disclosed method for whole blood assays.Type: GrantFiled: May 14, 2019Date of Patent: June 21, 2022Assignee: DIATRON MI PLCInventors: Márton Hegedüs, Dimitris Giantzoudis
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Patent number: 11366106Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.Type: GrantFiled: March 14, 2016Date of Patent: June 21, 2022Assignee: LABRADOR DIAGNOSTICS LLCInventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Patent number: 11366043Abstract: The present disclosure relates to a gel-phase patch that performs a function of assisting in staining during a staining process such as a process of coming into contact with a specimen such as blood to perform a staining function of staining the specimen, a process of fixing the specimen, or a process of forming an optimal pH at a specimen stained by a staining sample. According to an aspect of the present disclosure, a contact-type staining patch includes a staining solution that reacts with a specimen and a gel receptor provided as a gel matrix of a mesh structure in which a pore that accommodates the staining solution is formed and the mesh structure prevents the staining solution in the pore from leaking or degenerating, and having a contact surface that comes into contact with the specimen to transfer some of the staining solution to the specimen.Type: GrantFiled: September 27, 2019Date of Patent: June 21, 2022Assignee: Noul Co., Ltd.Inventors: Dongyoung Lee, Kyunghwan Kim, Youngmin Shin, Hyunjeong Yang, Chanyang Lim
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Patent number: 11360005Abstract: The present disclosure relates to a gel-phase patch that performs a function of assisting in staining during a staining process such as a process of coming into contact with a specimen such as blood to perform a staining function of staining the specimen, a process of fixing the specimen, or a process of forming an optimal pH at a specimen stained by a staining sample. According to an aspect of the present disclosure, a contact-type staining patch includes a staining solution that reacts with a specimen and a gel receptor provided as a gel matrix of a mesh structure in which a pore that accommodates the staining solution is formed and the mesh structure prevents the staining solution in the pore from leaking or degenerating, and having a contact surface that comes into contact with the specimen to transfer some of the staining solution to the specimen.Type: GrantFiled: September 27, 2019Date of Patent: June 14, 2022Assignee: Noul Co., Ltd.Inventors: Dongyoung Lee, Kyunghwan Kim, Youngmin Shin, Hyunjeong Yang, Chanyang Lim
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Patent number: 11353448Abstract: Methods and compositions for quantifying the cellular concentration of cyclic adenosine monophosphate (cAMP), cyclic guanine monophosphate (cGMP), glutathione, glucose, and glutamine in a single cell include the use of conjugates and analogs in immunofluorescent assays for on-chip quantification. These metabolite immunofluorescent assays may be incorporated with proteomic assays for simultaneous single cell analysis of metabolites and proteins.Type: GrantFiled: February 16, 2016Date of Patent: June 7, 2022Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Min Xue, Wei Wei, James R. Heath