Patents Examined by Ardin H. Marschel
  • Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
    Patent number: 7345039
    Abstract: Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidine, taurultam or mixtures thereof.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: March 18, 2008
    Assignee: Ed. Geistlich Soehne AG fuer chemische Industrie
    Inventors: H. Paul Redmond, Rolf W. Pfirrmann
  • Treatment of disorder related to low cyclic GMP levels
    Patent number: 7345079
    Abstract: Disclosed in this invention is a method of treating a disorder associated with low cGMP levels. The method includes administering to a subject in need thereof an effective amount of a compound having a pyrazolyl core, a first aryl group bonded to 3-C of the pyrazolyl core, and a second aryl group fused at 4-C and 5-C of the pyrazolyl core. Also disclosed are pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: March 18, 2008
    Assignee: Yung Shin Pharmaceuticals Industrial Co., Ltd
    Inventors: Che-Ming Teng, Fang-Yu Lee, Sheng-Chu Kuo
  • Pharmaceutical composition for use for the treatment of malignancies comprising in combination a bisphosphonates, a cox-2 inhibitor and a taxol
    Patent number: 7345088
    Abstract: A pharmaceutical composition for treatment of malignancies, in particular a malignant disease which is associated with the development of bone metastases or excessive bone resorption, comprises in combination a bisphosphonates, COX-2 inhibitor and/or a taxol or derivative thereof for simultaneous, sequential or separate use. Also provided is a method of treating a patient suffering from a malignant disease comprising administering to the patient an effective amount of a bisphosphonates, an effective amount of a COX-2 inhibitor and/or and effective amount of a taxol or derivative thereof.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: March 18, 2008
    Assignees: Penn State Research Foundation, Novartis AG
    Inventors: Jonathan Green, Allan Lipton, Lois Mary Witters
  • Gossypol co-crystals and the use thereof
    Patent number: 7342046
    Abstract: This invention relates to compositions comprising co-crystals of (?)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (?)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: March 11, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Jiangyong Chen
  • Method of treating chronic fatigue syndrome
    Patent number: 7338953
    Abstract: Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: March 4, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik H. F. Wong, Saeeduddin Ahmed, Robert C. Marshall, Robert McArthur, Duncan P. Taylor, Lars Birgerson
  • Method of treatment of prostate cancer and composition for treatment thereof
    Patent number: 7332525
    Abstract: A method and composition for the treatment of prostate cancer comprises an effective amount of a nonsteroidal antiandrogen and an effective amount of a selective estrogen receptor modulator. The composition has fewer side effects such as breast tenderness and gynecomastia and also is more effective as an adjuvant therapy to prevent the reoccurrence of prostate cancer.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: February 19, 2008
    Inventor: Erik P. Castle
  • Substitute benzothiophene compounds
    Patent number: 7329764
    Abstract: Disclosed are compounds of the formula I shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: February 12, 2008
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Zhidong Chen, John David Ginn, Eugene Richard Hickey, Weimin Liu, Can Mao, Tina Marie Morwick, Peter Allen Nemoto, Denice Spero, Sanxing Sun
  • Stabilized polynucleotide complexes and methods
    Patent number: 7323297
    Abstract: The invention comprises stabilized polynucleotide complexes that have a cryoprotectant and are lyophilized. Cryoprotectant compounds comprise carbohydrates or sugars, preferably lactose and sucrose, but also glucose, maltodextrins, mannitol, sorbitol, trehalose, and others. Other suitable cryoprotectants include amino acids such as betaines and prolines. Polynucleotide complexes stabilized according to the invention can be used for transfection, and exhibit improved tranfection efficiency with respect to polynucleotide complexes without cryoprotection.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 29, 2008
    Assignee: The Regents of the University of California
    Inventors: Francis C. Szoka, Jr., Jinkang Wang
  • Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth
    Patent number: 7323481
    Abstract: Use of thiazolidinedione derivatives for the preparation of medicaments for inhibiting or reducing tumour growth or metastases, alone or in combination with an RXR agonist or well-known antitumour agent.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: January 29, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Sabine Bauer, Markus Meyer, Tobias Schnitzer, Christine Schuell, Hans-Peter Wolff
  • Solid pharmaceutical composition containing benzofuran derivatives
    Patent number: 7323493
    Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: January 29, 2008
    Assignee: Sanofi-Aventis
    Inventors: Bernard Abramovici, Jean-Claude Gautier, Jean-Claude Gromenil, Jean-Marie Marrier
  • Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer
    Patent number: 7320996
    Abstract: The present invention relates to methods for treatment or prevention of neoplasia disorders using protein tyrosine kinase inhibitors of the formula I: wherein R1, R2, R3, R4, R5, R6, and R7 are defined herein, in combination with cyclooxygenase inhibitors, in particular cyclooxygenase-2 selective inhibitors.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: January 22, 2008
    Assignees: Sugen, Inc, Pharmacia Corporation
    Inventors: Jaime Masferrer, Parul Doshi, Julie Cherrington
  • Inhibition of exoprotein production using isoprenoid compositions
    Patent number: 7294651
    Abstract: Methods and compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: November 13, 2007
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Rae Ellen Syverson, Richard A. Proctor
  • Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof
    Patent number: 7276514
    Abstract: The invention includes composition comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or ischemia. The invention also includes methods for the treatment and prevention of cardiac injury comprising contacting a compression of the invention with a human patient.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: October 2, 2007
    Assignee: Charitable Leadership Foundation - Medical Technology Acceleration Program
    Inventor: Paul J. Davis
  • Method of treating chronic fatigue syndrome
    Patent number: 7276503
    Abstract: Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. Embodiments of these methods can diminish adverse side effects.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: October 2, 2007
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik H. F. Wong, Saeeduddin Ahmed, Robert C. Marshall, Robert McArthur, Duncan P. Taylor
  • Treatment of neurotic disorders
    Patent number: 7271194
    Abstract: Use of escitalopram (the S-(+)-enantiomer of citalopram) or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment of neurotic disorders is provided, including anxiety states, in particular generalised anxiety disorder and social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder and panic attacks.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: September 18, 2007
    Assignee: H. Lundbeck A/S
    Inventors: Connie Sanchez, Sandra Hogg
  • Treatment of neurotic disorders
    Patent number: 7265151
    Abstract: Use of escitalopram (the S-(+)-enantiomer of citalopram) or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment of neurotic disorders is provided, including anxiety states, in particular generalised anxiety disorder and social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder and panic attacks.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: September 4, 2007
    Assignee: H. Lundbeck A/S
    Inventors: Connie Sanchez, Sandra Hogg
  • Soluble forms of amoxicillin and treatment of animals
    Patent number: 7244720
    Abstract: A solid mixture or aqueous solution of amoxicillin antibacterial agent with a material that aids in its dissolution in water to render it ingestive and palatable.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: July 17, 2007
    Assignee: Pharmaceutical Solutions, Inc.
    Inventors: Michael Strobel, Pat Soderland
  • Methods for treating an impairment in memory consolidation
    Patent number: 7244769
    Abstract: Impairments in memory consolidation are treated with an amphetamine compound. In one embodiment, the method includes administering an l-amphetamine compound. In another embodiment, the method includes administering an l-methamphetamine compound. The method can include determining memory consolidation before, during and/or after administering the amphetamine compound.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: July 17, 2007
    Assignee: Cognition Pharmaceuticals, LLC
    Inventors: Mel H. Epstein, Kjesten A. Wiig
  • Method of treating peripheral neuropathy
    Patent number: 7241762
    Abstract: Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: July 10, 2007
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik H. F. Wong, Saeeduddin Ahmed, Robert C. Marshall, Robert McArthur, Duncan P. Taylor
  • Irrigation solution and methods for use
    Patent number: 7238342
    Abstract: Methods and solutions are provided for removal of the smear layer on prepared tooth and bone surfaces, especially in endodontic environments.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: July 3, 2007
    Assignee: Dentsply International
    Inventors: Mahmoud Torabinejad, William B. Johnson