Patents Examined by Arie M. Michelsohn
  • Neurotrophic peptides
    Patent number: 5475088
    Abstract: The present invention involves peptides derived from nerve growth factor receptor protein. Such peptides are characterized by competing for NGF binding to NGF receptor at high concentrations while accentuating NGF binding at low concentrations. Preferred peptides include Cys-Glu-Glu-Cys-Pro-Glu-OH, Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH, Gln-Asp-Lys-Gln-Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH and Cys-Gln-Asp-Lys-Gln-Asn-Thr-Val-Cys-Glu-Glu-Cys-Pro-Glu-OH.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: December 12, 1995
    Assignee: Board of Regents, The University of Texas System
    Inventor: J. Regino Perez-Polo
  • Modified OmpA signal sequence for enhanced secretion of polypeptides
    Patent number: 5470719
    Abstract: A signal peptide sequence and nucleic acids encoding this sequence which are useful for improving the secretion efficiency of NGF polypeptides are provided. Also provided is a method for preparing Met-less NGF polypeptides.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: November 28, 1995
    Inventors: Shi-Yuan Meng, Charles F. Morris, Larry B. Tsai