Abstract: A method and apparatus is provided to improve the image quality of images generated by analytical reconstruction of a computed tomography (CT) image. This improved image quality results from a deep learning (DL) network that is used to filter a sinogram before back projection but after the sinogram has been filtered using a ramp filter or other reconstruction kernel.

Abstract: A method for performing a computer-aided diagnosis (CAD) for universal lesion detection includes: receiving a medical image; processing the medical image to predict lesion proposals and generating cropped feature maps corresponding to the lesion proposals; for each lesion proposal, applying a plurality of lesion detection classifiers to generate a plurality of lesion detection scores, the plurality of lesion detection classifiers including a whole-body classifier and one or more organ-specific classifiers; for each lesion proposal, applying an organ-gating classifier to generate a plurality of weighting coefficients corresponding to the plurality of lesion detection classifiers; and for each lesion proposal, performing weight gating on the plurality of lesion detection scores with the plurality of weighting coefficients to generate a comprehensive lesion detection score.

Abstract: A computer system implements a neural network to process raw dental images to detect and number teeth and to diagnose pathological, non-pathological, and post-treatment conditions. Detected teeth, corresponding numbers, and any corresponding detected conditions are correlated to the dental image and presented in a graphical user interface comprising the image and a standard, symbolic dental chart associating the tooth number, detected conditions, and regions of the image to teeth represented in the symbolic chart.

Abstract: Anatomical and functional assessment of coronary artery disease (CAD) using machine learning and computational modeling techniques deploying methodologies for non-invasive Fractional Flow Reserve (FFR) quantification based on angiographically derived anatomy and hemodynamics data, relying on machine learning algorithms for image segmentation and flow assessment, and relying on accurate physics-based computational fluid dynamics (CFD) simulation for computation of the FFR.

Abstract: A system for determining the viability of an embryo comprises an imaging device, an excitation device configured to direct an excitation energy at an embryo, a controller communicatively connected to the imaging device and the excitation device, configured to drive the excitation device and collect images from the imaging device at an imaging frequency, a processor performing steps comprising acquiring a set of images from the imaging device, performing a Fourier Transformation to generate a set of phasor coordinates, computing a D-trajectory, computing a set of values of additional parameters, comparing the set of values to a set of stored values related to embryos of known viability, and calculating a viability index factor of the embryo from the set of values and the set of stored values. Methods of calculating embryo viability and determining one or more properties of a tissue are also described.

Abstract: A method for determining whether there is an abnormality in a brain includes steps of: receiving a to-be-determined (TBD) 3D brain image; implementing the calibration procedure on the TBD 3D brain image; generating a first TBD image of WM, a second TBD image of GM, and a third TBD image of CSF based on a multi-voxel pattern of the TBD 3D brain image; and inputting the first TBD image of WM into a first DNN model, the second TBD image of GM into a second DNN model, and the third TBD image of CSF into a third DNN model to determine whether there is an abnormality in the white matter, the gray matter and the cerebrospinal fluid, respectively.

Abstract: An illustrative computing system is configured to perform volumetric reconstruction based on a confidence field. In one implementation, the computing system accesses color and depth data captured from a plurality of different vantage points for a surface point on a surface of an object. Based on the color and depth data captured from the plurality of different vantage points, the computing system determines a confidence field value associated with the surface point. Based on the confidence field value associated with the surface point, the computing system generates reconstructed color and depth data for a volumetric reconstruction of the surface of the object. Corresponding methods and systems are also disclosed.

Abstract: A computer-implemented method for processing 3D image data of a dento-maxillofacial structure is described wherein the method may comprise the steps of: receiving 3D image data defining a volume of voxels, a voxel being associated with a radiodensity value and a position in the volume and the voxels providing a 3D representation of a dento-maxillofacial structure; using the voxels of the 3D image data to determine one or more 3D positional features for input to a first deep neural network, a 3D positional feature defining information aggregated from the entire received 3D data set; and, the first deep neural network receiving the 3D image data and the one or more positional features at its input and using the one or more 3D positional features to classify at least part of the voxels of the 3D image data into jaw, teeth and/or nerve voxels.

Abstract: For a particularly comprehensive identification of hollow organ systems, a method is provided for producing a digital subtraction angiography of a hollow organ system of a patient. The method includes: providing mask image data recorded by an X-ray device; providing at least first fill image data recorded by the X-ray device, which has been recorded during an at least partial filling of the hollow organ system with a contrast agent; starting from a first intravenous and a second intraarterial contrast agent injection following in time; ascertaining at least first subtraction image data by subtracting the mask image data from the at least first fill image data; ascertaining final subtraction image data from the at least first subtraction image data; and segmenting the final subtraction image data and assigning the pixels or voxels of the final subtraction image data to at least two different intensity classes based on their respective intensity value.

Abstract: A navigation system uses markers that are identifiable in images of an environment being navigated to determine the location of a portable device in the environment. The portable device takes images of the environment, and those images are analysed to identify markers in the images and the pose of the portable device based on the image of the marker. The identified marker and the determined pose of the portable device are then used to determine the location and orientation of the portable device in the environment being navigated.

Abstract: Provided are ex vivo systems and methods of predicting the response of a drug or other agent on a tissue. In some embodiments, the systems and methods comprise cutting a tissue into tissue fragments, adding a drug or other agent to the tissue fragments based on an estimated tumor content, and performing an ex vivo measurement on the tissue fragments.

Abstract: Embodiments discussed herein facilitate determining a diagnosis and/or prognosis for prostate cancer based at least in part on three-dimensional (3D) pathomic feature(s). One example embodiment comprises a computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, comprising: accessing a three-dimensional (3D) optical image volume comprising a prostate gland of a patient; segmenting the prostate gland of the 3D optical image volume; extracting one or more features from the segmented prostate gland, wherein the one or more features comprise at least one 3D pathomic feature; and generating, via a model based at least on the one or more features, one or more of the following based at least on the extracted one or more features: a classification of the prostate gland as one of benign or malignant, a Gleason score associated with the prostate gland, or a prognosis for the patient.

Abstract: A computer-implemented method for determining and evaluating an objective tumor response to an anti-cancer therapy using cross-sectional images can include receiving cross-sectional images of digital medical image data and identifying target lesions within the cross-sectional images. For each of the target lesions, a target lesion type and anatomical location is identified, a segmenting tool is activated for segmenting the target lesions into regions of interest, lesion metrics are automatically extracted from the regions of interest according to tumor response criteria, and conformity of target lesion identification is monitored using rules associated with the tumor response criteria, prompting a user to address any nonconforming target lesion. The method also includes receiving a presence/absence of metastases, determining changes in lesions metrics, and deriving an objective tumor response based on the tumor response criteria.

Abstract: A clinical trial re-evaluation system is operable to perform at least one assessment function on a set of medical scans for each of a first subset of a set of patients of a failed clinical trial to generate automated assessment data for each of the first subset of the set of patients. The first subset of the set of patients corresponds to a subset of human assessment data determined to have failed to meet criteria of the clinical trial. Patient re-evaluation data is generated for each of the first subset of the set of patients by comparing the automated assessment data to the criteria. The patient re-evaluation data for a second subset of the first subset of the set of patients indicates the automated assessment data passes the criteria. Trial re-evaluation data is generated based on the patient re-evaluation data for transmission to a computing device for display.

Abstract: A method of generating physical component qualification data using computed tomography (CT) includes obtaining qualified CT data from a CT scanner for at least one qualified physical component. Qualification data is generated based on the qualified CT data, where the qualification data defines a qualification envelope.

Abstract: The current disclosure provides for mapping medical images to style transferred medical images using deep neural networks, while maintaining clinical quality of the style transferred medical image, thereby enabling a clinician to evaluate medical images in a preferred style without loss of clinically relevant content. In one embodiment the current disclosure provides for a method comprising, acquiring a medical image of an anatomical region of a subject, wherein the medical image is in a first style, selecting a target style, wherein the target style is distinct from the first style, selecting a clinical quality metric, selecting a trained style transfer network based on the target style and the clinical quality metric, mapping the medical image to a style transferred medical image using the trained style transfer network, wherein the style transferred medical image is in the target style, and displaying the style transferred medical image via a display device.

Abstract: Described herein is a method of registering a medical image of a subject with a 3D model of a subject, including calibrating the 3D model globally by aligning markers on the subject with corresponding markers on the 3D model; and calibrating the 3D model locally by aligning a scanning image of an internal structure of the subject with a corresponding internal structure of the 3D model. Also described herein is an apparatus of performing the method.

Abstract: A system evaluates currency in an area using image processing. In some examples, the system receives an image of an area from an image sensor, processes the image to identify at least one item of currency in the area, determine a value of the currency irrespective of validity, and counts the currency. In various examples, the system receives an image of an area from an image sensor; processes the image to identify at least one item of currency in the area; determines whether the currency has an error condition; and when the currency is determined to have the error condition, provides output on the error condition. In a number of examples, the system receives an image of an area from an image sensor; processes the image to identify at least one item of currency in the area; determines whether the currency is valid; and when the currency is determined to be suspect, provides output on the currency.

Abstract: The systems and methods can accurately and efficiently determine a myocardial risk from a lesion disposed along a coronary segment using hemodynamic characteristic(s) associated with one or more sections of the corresponding lesion site. The method may include segmenting one or more lesion sites disposed along at least one arterial segment of the one or more arterial segments of the coronary model into one or more sections. Each lesion site includes a lesion. The method may include determining one or more characteristics for at least one section using at least the one or more characteristics associated with the at least one arterial segment. The one or more characteristics for the at least one section including hemodynamic force characteristic(s) (e.g., wall shear stress (WSS)). The method may include determining one or more risk indices for each lesion site using at least the hemodynamic force characteristic(s) for the at least one section.

Abstract: Methods that implement image-guided tissue analysis, MRI-based computational modeling, and imaging informatics to analyze the diversity and dynamics of molecularly-distinct subpopulations and the evolving competitive landscapes in human glioblastoma multiforme (“GBM”) are provided. Machine learning models are constructed based on multiparametric MRI data and molecular data (e.g., CNV, exome, gene expression). Models can also be built based on specific biological factors, such as sex and age. Inputting MRI data into the trained predictive models generates maps that depict spatial patterns of molecular markers, which can be used to quantify and co-localize regions molecularly distinct subpopulations in tumors and other regions, such as the non-enhancing parenchyma, or brain around tumor (“BAT”) regions.