Patents Examined by Austin Jeffries
  • Identification and uses of vasculature forming progenitor cells and progenitor cell combinations
    Patent number: 11369641
    Abstract: Methods, compositions, and kits for producing functional blood vessels, and progenitors thereof are provided. Human disorders of the vascular system are treated by reconstitution of functional vessels in vivo through co-transplantation with supporting niche stromal cells for treatment of ischemic injury in the peripheral limbs and heart. The cell populations of the invention, when engrafted into a recipient, anastomose with host vasculature and regenerate functional blood vessels.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: June 28, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Charles K. F. Chan, Andrew Stephen Lee, Michael T. Longaker, Irving L. Weissman, Joseph Wu, Divya Nag, Eun Young Seo
  • Cell freezing medium for clinical use
    Patent number: 11363812
    Abstract: Provided in the present invention is a cell freezing medium for clinical use. In particular, the cell freezing medium of the present invention comprises the following components: (1) human albumin; (2) cryoprotectant: the cryoprotectant comprises a combination of one or more of dimethyl sulfoxide, glycerol, and ethylene glycol; (3) a saline buffer; wherein the salt buffer is a solution containing Na+, K+, Mg+, Cl?, and CH3COO? ions; (4) a vitamin; and (5) an amino acid, wherein the human albumin concentration is 1%-20% (w/v). The cell, after long-term cryopreservation with the freezing medium of the present invention, has a high viability, and the cellular efficiency maintains a high uniformity. The grade of purity of the freezing medium of the present invention is the pharmaceutical grade or USP grade; and the freezing medium is safe and reliable for clinical use, and can be used or conventional adherent and suspension cells.
    Type: Grant
    Filed: December 25, 2017
    Date of Patent: June 21, 2022
    Assignee: CELLULAR BIOMEDICINE GROUP HK LIMITED
    Inventors: Fei Wang, Jiaping He, Dijun Zhao, Victor Liu, Dingzhu Yang
  • Cell preparation and method for producing cell preparation
    Patent number: 11311579
    Abstract: The present invention provides a method for producing a cell culture for promoting angiogenesis or axon outgrowth, particularly for the treatment of a cerebrovascular disease, an ischemic cardiac disease or traumatic brain injury and spinal cord injury, which comprises culturing a cell population containing microglia and/or monocytes under conditions of low oxygen concentration and/or low sugar concentration to produce the culture, a cell preparation obtained by the method, and a method for treating a cerebrovascular disease, an ischemic cardiac disease or traumatic cerebrospinal neuropathy by using the cell preparation.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: April 26, 2022
    Assignee: NIIGATA UNIVERSITY
    Inventors: Takayoshi Shimohata, Masato Kanazawa