Abstract: The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for prophylaxis, and methods for diagnosis and treatment of HIV infection.
Type:
Grant
Filed:
September 29, 2017
Date of Patent:
January 12, 2021
Assignees:
The Rockefeller University, California Institute of Technoloqy
Inventors:
Johannes Scheid, Michel Nussenzweig, Pamela J. Bjorkman, Ron Diskin
Abstract: Methods and compositions are provided for inducing phagocytosis of a target cell, treating an individual having cancer, treating an individual having an intracellular pathogen infection (e.g., a chronic infection), and/or reducing the number of inflicted cells (e.g., cancer cells, cells infected with an intracellular pathogen, etc.) in an individual. Methods and compositions are also provided for predicting whether an individual is resistant (or susceptible) to treatment with an anti-CD47/SIRPA agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent (e.g., co-administration of an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent). Kits are also provided for practicing the methods of the disclosure.
Type:
Grant
Filed:
April 25, 2019
Date of Patent:
January 12, 2021
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Roy Louis Maute, Kipp Andrew Weiskopf, Aaron Michael Ring, Irving L. Weissman
Abstract: The present invention is an antibody including an amino acid sequence, wherein the amino acid sequence includes, in an N- to C-direction, the following structural domains: N-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4-C wherein FR denotes a framework region amino acid sequence and CDR denotes a complementary determining region amino acid sequence; the CDR1 includes an amino acid sequence represented by SEQ ID NO: 1; the CDR2 includes an amino acid sequence represented by SEQ ID NO: 2; and the CDR3 includes an amino acid sequence represented by SEQ ID NO: 3. The antibody is capable of binding to an intranuclear protein of an influenza virus.
Abstract: The present invention relates to recombinant modified vaccinia virus Ankara (MVA) and to methods of using the same. In particular, the invention relates to recombinant MVA comprising a nucleotide sequence encoding for a structural protein of an equine encephalitis virus (EEV) excluding encoding for a capsid protein of the EEV, a composition in particular a pharmaceutical composition, a vaccine or kit comprising the recombinant MVA, uses and methods thereof e.g., suitable for treating and/or preventing a western, Venezuelan, and/or eastern equine encephalitis virus caused disease.
Abstract: Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.
Type:
Grant
Filed:
May 3, 2017
Date of Patent:
January 5, 2021
Assignees:
CHILDREN'S MEDICAL RESEARCH INSTITUTE, THE SYDNEY CHILDREN'S HOSPITALS NETWORK (RANDWICK AND WESTMEAD) (INCORPORATING THE ROYAL ALEXANDRA HOSPITAL FOR CHILDREN), THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (WASHINGTON DC)
Inventors:
Claus Hallwirth, Ian Alexander, Richard Smith, Robert Kotin
Abstract: The present disclosure provides for an immunogenic composition against epizootic hemorrhagic disease virus (EHDV). The immunogenic composition has been shown to be efficacious in inducing serum neutralizing antibodies against EHDV and intended to be used to prevent or reduce clinical symptoms associated with EHDV infection in susceptible animals. The disclosure provides for composition and methods that represent an improvement over previous strategies for treating and preventing EHDV.
Type:
Grant
Filed:
September 18, 2017
Date of Patent:
January 5, 2021
Assignees:
Kansas State University Research Foundation, The United States of America, as reoresented by The Secretary of Agriculture
Inventors:
Juergen A. Richt, Igor Morozov, Sun Young Sunwoo, William C. Wilson
Abstract: Modified E1a regulatory sequences are provided, wherein at least one Pea3 binding site, or a functional portion thereof, is deleted. Also provided are modified E1a sequences that selectively express particular isoforms. Also provided is an E1b-19K clone insertion site. These modified sequences can be used individually, or in combination with one another, to provide tumor-selective expression of proteins.
Type:
Grant
Filed:
August 8, 2018
Date of Patent:
December 29, 2020
Inventors:
Tony Reid, Farah Hedjran, Shantanu Kumar
Abstract: Described herein is the generation of optimized H5N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on human and avian H5N1 isolates. Provided herein are optimized H5N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
Type:
Grant
Filed:
December 6, 2018
Date of Patent:
December 15, 2020
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
Ted M. Ross, Corey J. Crevar, Brendan M. Giles
Abstract: Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
Abstract: An immunogenic composition comprising (i) a non-virion influenza virus antigen prepared from a virus grown in cell culture; and (ii) an adjuvant. Preferred adjuvants comprise oil-in-water emulsions.
Type:
Grant
Filed:
November 6, 2006
Date of Patent:
November 24, 2020
Assignee:
Seqirus UK Limited
Inventors:
Rino Rappuoli, Derek O'Hagan, Giuseppe Del Giudice
Abstract: The present invention relates to compositions comprising two or more DNA plasmids encoding consensus and transmitted founder HIV envelope glycoproteins which expressed and induce a potent immune response.
Type:
Grant
Filed:
September 15, 2017
Date of Patent:
November 10, 2020
Assignees:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
Abstract: The present invention relates to DEV and the uses thereof. The invention is particularly suited to vaccinate poultry against avian pathogens.
Abstract: This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use.
Abstract: A method for diagnosing a limbic encephalitis, PNS, encephaloymyelitis, leukoencephalopathy, retinitis or optic atrophy, includes detecting a bornavirus in a sample, preferably from the group comprising mammalian 2 bornavirus, even more preferably VSBV-1, and mammalian 1 bornavirus, even more preferably BoDV-1; to a carrier containing a means for the capture of an antibody against at least one polypeptide selected from the group of BoDV-1-N, BoDV-1-P, VSBV-N and VSBV-P. A kit contains the carrier and a means for the detection of a captured antibody and a control for the detection of the presence of a sample. The carrier or kit or of a primer can be used for the detection of a bornavirus or a probe can be used for the diagnosis of an encephalitis, for the prognostication of post-transplantation complications, for the monitoring of a therapy of an encephalitis or of post-transplantation complications or for the differentiation between an autoimmune encephalitis and an encephalitis caused by infection.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
October 13, 2020
Assignee:
EUROIMMUN Medizinische Labordiagnostika AG
Inventors:
Erik Lattwein, Wolfgang Meyer, Wolfgang Schlumberger, Julia Janz, Anthonina Ott, Thomas Scheper, Jonas Schmidt-Chanasit, Dennis Tappe
Abstract: Human immunodeficiency virus (HIV) envelope proteins having mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins have certain amino acid substitutions at specified positions in the envelope protein sequence. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved trimer yield as compared to an HIV envelope protein that does not have one or more of the indicated amino acid substitutions. Also provided are nucleic acid molecules and vectors encoding the HIV envelope proteins, as well as compositions containing the HIV envelope proteins, nucleic acid, and vectors.
Abstract: Cancer immunotherapy is enhanced by co-expression of cancer associated or tumor-specific (neo)epitopes with co-stimulatory molecules and/or other immune activators. Where desired, treatment may be enhanced by administration of a immune checkpoint inhibitor.
Type:
Grant
Filed:
December 7, 2016
Date of Patent:
October 6, 2020
Assignee:
Nant Holdings IP, LLC
Inventors:
Patrick Soon-Shiong, Shahrooz Rabizadeh, Kayvan Niazi
Abstract: This document provides methods and materials for treating HIV infections. For example, methods and materials for using one or more proteosome inhibitors in combination with one or more other agents to treat HIV infections are provided.
Type:
Grant
Filed:
February 19, 2016
Date of Patent:
September 29, 2020
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.
Type:
Grant
Filed:
September 23, 2013
Date of Patent:
September 22, 2020
Assignees:
Erasmus University Medical Center Rotterdam, Dr. Soliman Fakeeh Hospital
Inventors:
Bartholomeus Leonardus Haagmans, Theodorus Marinus Bestebroer, Sander van Boheemen, Ronaldus Adrianus Maria Fouchier, Albertus Dominicus Marcellinus Erasmus Osterhaus, Ali Moh Zaki, Victor Stalin Raj, Berend Jan Bosch