Abstract: A replaceable needle assembly is provided for a retractable syringe comprising a barrel and a plunger, whereby the retractable needle can be replaced by a user without affecting the retraction mechanism. A mounting member is removably mountable to the barrel by way of a screw-thread connection and a needle mount is removably coupled to the mounting member. A needle is mounted to the needle mount. The barrel comprises a needle mount retainer that comprises a plurality of fingers that engage the retractable needle mount to prevent inadvertent retraction. The plunger comprises a collapsible seal which maximizes the efficiency of fluid delivery prior to the plunger engaging the retractable needle mount for retraction. An initially compressed spring decompresses to drive retraction of the plunger and the engaged needle mount. A lock formed between the plunger and barrel prevents further use of the plunger after retraction.

Abstract: A device, system and method for treatment of tissue by direct application thereto of therapeutic substances in the form of a stream of therapeutic droplets carried in a high velocity gas. The high velocity gas is produced by accelerating a flow of gas through at least one gas discharge nozzle. At least one flow of therapeutic liquid is introduced into the high velocity gas through at least one liquid discharge nozzle, thereby fragmenting the at least one flow of therapeutic liquid into a stream of therapeutic droplets. The stream is accelerated to a velocity similar to the velocity of the gas discharge flow. The accelerated therapeutic droplet stream is then applied to a tissue mass for therapeutic treatment. The therapeutic substances are provided by containers mounted directly on the device. The containers contain predefined dosages and/or concentrations of the therapeutic substances.

Abstract: In accordance with non-limiting examples, a nebulizer includes a main body comprising an air channel section and further comprising a mixing chamber and a venturi positioned to be placed within the patient's oral cavity and configured to receive medicine and air and mix the medicine and air within the mixing chamber and receive the air flow through the venturi and cause the medicine entering the mixing chamber to be atomized by the action of air flowing through the venturi. An air flow sensor is associated with the main body and configured to measure the air flow created by the patient's one of at least inhaling and exhaling air.

Abstract: A system of rotate-to-advance medical devices including catheters, dilators, occluders, stents, suprapubic catheters and camera introducers configured with external screw threads and depending substantially on rotation for means of advancement and emplacement in mammalian genitourinary and gastrointestinal passages and organs.

Abstract: A system for controlling temperature of intravenous fluids includes a thermal treatment device and a temperature sensing device to measure a temperature of the fluid flowing through the sensor. The temperature sensing device may simultaneously collect two temperature measurements. For example, the sensing device may include sensors that measure the temperature of the fluid at two disparate locations along the medical fluid line. Additionally, the sensors may measure the temperature of the fluid within the medical fluid line, as well as the ambient temperature outside of the line. The thermal treatment device includes a conduit configured to have a nonlinear flow path through the device. The thermal treatment device thermally treats fluid within the conduit to a desired temperature or range.

Abstract: An injection device having a housing, a dose setting member being operable to set a desired dose, a piston rod adapted to cooperate with a piston to cause a set dose to be expelled, and a mode locking member. The mode locking member is adapted to be in a first extreme position and in a second extreme position. When the mode locking member is in the first extreme position the piston rod is prevented from cooperating with the piston, and when the mode locking member is in the second extreme position the dose setting member is prevented from being operated to set a dose. The mode locking member is adapted to be in the first extreme position during dose setting and the second extreme position during injection of a set dose.

Abstract: An assembly of a drug delivery device comprises a body (10) having a distal end (11) and a proximal end (12), a drive assembly (4) arranged substantially within the body (10) to facilitate dispense of a medicinal product and a button member (5) arranged at the proximal end (12) of the body (10) and adapted to act upon the drive assembly (4). The drive assembly (4) has an initial pre-ready state, a transient state and a ready state; in the pre-ready and transient states the button member (5) is twistable with respect to the body (10) to act upon the drive assembly (4) and wherein in the ready state the button member (5) is axially moveable but not substantially twistable with respect to the body (10) to act upon the drive assembly (4) to dispense a dose of the medicinal product.

Abstract: A skin treatment device includes a handle and a tip, having a skin applying surface, detachably coupled to the handle. A fluid delivery structure is formed at skin applying surface and has an aperture and a vacuum entry port. A fluid detouring path is defined between the aperture and the vacuum entry port for prolonging a traveling path of fluid from the aperture and the vacuum entry port. An abrading structure, an electrode structure, and a micro-needling structure are selectively provided at the skin applying surface with the fluid delivery structure to provide multiple functions of the tip.

Abstract: A lubrication device for lubricating a joint of a human or mammal patient, which is entirely implantable in a patient's body, comprises a reservoir for storing a lubricating fluid and a fluid connection for introducing the lubricating fluid into the joint when the device is implanted in the patient's body. Further, the fluid connection comprises a fluid connection device connecting the reservoir with the joint such that a lubricating fluid flow is established from the reservoir into the joint. The fluid connection comprises either an infusion needle adapted to be intermittently placed into the joint for injecting the lubricating fluid, or a tube adapted to be permanently placed into the joint for continuously injecting the lubricating fluid.

Abstract: A resettable drive assembly for a drug delivery device (1) is provided. The drive assembly comprises a drive unit (3) for driving a piston rod (5) in a dispense operation of the device (1). The drive unit (3) comprises a first drive member (35), a second drive member (37) and locking means preventing a relative rotational movement of the first (35) and the second drive member (37) during a dispense operation and allowing a relative rotational movement for enabling a resetting of the device (1). Moreover, a drug delivery device (1) comprising a resettable drive assembly is provided.

Abstract: A medical device consists of a dual lumen catheter with three intra-connecting balloons comprising a balloon stent. The adjustable tissue approximation using negative pressure exerted between device and mucosa of stomach/esophagus/colon with improved injury site isolation via adjustable balloon stent and added potential of negative pressure application to injury site for active healing process and distal feeding potential.

Abstract: A dermal access device for fluid injection comprising a bearing block for fixation of the device onto a patient's skin, a slider movably connected to the bearing block and a hollow needle arranged at the slider for puncturing the skin, wherein the needle creates a puncture angle with respect to the skin surface when puncturing the skin, which does not exceed 25°. A dermal access device for fluid injection comprising a bearing block for fixation of the device onto a patient's skin, a movable slider connected to the bearing block and a hollow needle arranged at the slider for puncturing the skin, wherein the device comprises a first stop for limiting a first moving direction of the slider at a first puncture position of the needle, where the device comprises a second stop at a second puncture position of the needle for limiting the second moving direction of the slider.

Abstract: A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter. Each of the disk, lever and ring actuators are of a design that allows existing control handles and catheters to be readily modified to include these actuators.

Abstract: An insufflating surgical instrument adapted for movement across an abdominal wall to insufflate an abdominal region of a patient is disclosed. The instrument comprises a shaft having an insufflation channel extending between a proximal end and a distal end, the insufflation channel being adapted for connection to a source of fluid under pressure at the proximal end. A tip is at the distal end and a vent hole is formed in the tip being in connection with the insufflation channel and adapted to expel fluid under pressure to insufflate the abdominal region. The tip is formed of a transparent material to facilitate visualization of the abdominal wall and region. The shaft includes a lumen extending along the axis between the proximal end and the distal end to enable insertion of a laparoscope. The lumen and insufflation channel may be formed as separate channels or as one shared channel.

Abstract: An injection device comprising a medicament container, a needle attached to the container, and a mechanism for automatic penetration of the needle, injection of medicament and withdrawal of the needle. The device operates by initiating a penetration sequence, followed by an injection sequence and followed by a withdrawal sequence. A previous sequence can trigger a subsequent sequence. The device further comprises a dampening mechanism arranged and designed to dampen the movement of the injection mechanism during an injection sequence.

Abstract: A programming device for an implantable drug pump includes a display device, a communication device, and a controller. The communication device is adapted to facilitate a communication link between the programming device and an implantable drug pump. The controller adapted to receive bolus data stored on the implantable drug pump when the communications link has been established, to process the bolus data, and to control the display device to generate a visual representation of numbers of bolus attempts for multiple periodic time intervals.

Abstract: An insertion device for use in assisting with the placement of a medical device within the body of a patient is disclosed. For example, the insertion device can be employed to assist with the placement of an introducer, which provides a conduit for insertion of a catheter into the body. In one embodiment, the insertion device comprises a needle that is removably disposed within a bore defined by the medical device, and a needle retraction assembly. The needle retraction assembly can position the needle in any one of a first position wherein a distal tip of the needle is disposed a predetermined distance distal to a distal end of the medical device, a second position wherein the needle distal tip is disposed distal but proximate to the distal end of the medical device, and a third position wherein the needle distal tip is retracted within the medical device bore.

Abstract: A transcutaneous multimodal delivery device for drug delivery and the methods of making and using the same are provided.

Abstract: A pump operations module having a base function includes only base function programming in the module itself but is configured to receive advanced delivery programs in a buffer for execution autonomously. An advanced interface module (AIM) is used to prepare advanced delivery programs and upload them to one or more delivery modules as well as monitor the performance of those modules. However, the advanced interface module does not control the execution of those advanced delivery programs by the pump operations modules. The AIM includes a touch screen and access to drug libraries. The AIM will generate graphical slide controls on the touch screen with the minimum and maximum values on the touch screen for the user to create an advanced delivery program for upload, to greatly lessen the risk of errors. Support for PK applications is provided.

Abstract: A catheter assembly for intracranial treatment of a subject that includes an outer tube that may be connected to an infusion or osmotic pump and delivered through a bendable catheter to the target brain site of the subject. The assembly facilitates regular accurate placement of drug or compound delivery at the tissue region without additional contact and minimizes trauma to the subject.