Patents Examined by Benjamin L Lebron
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Patent number: 11975305Abstract: Sorbents are disclosed which exhibit less inherent leaching of arsenic and antimony than what is achieved by conventional sorbents. The inventive sorbents are formed by a process which includes the steps of contacting the porous sorbent particulate with a solution of a metal oxide or metal hydroxide, or a metal oxide or metal hydroxide precursor, and depositing metal oxides and hydroxides within the pores of the porous sorbent particulate. Purification of water is also described.Type: GrantFiled: February 12, 2018Date of Patent: May 7, 2024Assignee: CALGON CARBON CORPORATIONInventors: Rebecca Distefano, Robert Vaughn
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Patent number: 11969532Abstract: The present invention discloses a microstructured discrimination device for separating hydrophobic-hydrophilic fluidic composites comprising particulate and/or fluids in a fluid flow. The discrimination is the result of surface energy gradients obtained by physically varying a textured surface and/or by varying surface chemical properties, both of which are spatially graded. Such surfaces discriminate and spatially separate particulate and/or fluids without external energy input. The device of the present invention comprises a platform having bifurcating microchannels arranged radially. The lumenal surfaces of the microchannels may have a surface energy gradient created by varying the periodicity of hierarchically arranged microstructures along a dimension. The surface energy gradient is varied in two regions. In one pre-bifurcation region the surface energy gradient generates a fluid flow.Type: GrantFiled: November 15, 2022Date of Patent: April 30, 2024Assignee: BVW Holding AGInventors: Lukas Bluecher, Michael Milbocker
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Patent number: 11969669Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for use.Type: GrantFiled: March 9, 2022Date of Patent: April 30, 2024Assignee: Cytiva Sweden ABInventor: Klaus Gebauer
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Patent number: 11969691Abstract: A clean water production system includes a photovoltaic panel and a first membrane distillation system having a first evaporation layer, first porous hydrophobic layer and first condensation layer. The first membrane distillation system is located under the photovoltaic panel. A second membrane distillation system has a second evaporation layer, second porous hydrophobic layer and second condensation layer. The second membrane distillation system is located under the first membrane distillation system. A thermoelectric generator is located under the second membrane distillation system converting heat to electricity.Type: GrantFiled: January 10, 2024Date of Patent: April 30, 2024Assignee: KING FAISAL UNIVERSITYInventors: Fatih Selimefendigil, Damla Okulu
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Patent number: 11957997Abstract: The present invention pertains to a liquid chromatography method of separating multicharged ions, and more particularly, to separating both positively charged and negatively charged ions by using a mobile phase composition with doubly charged ions and an ion-exchange column with a charged stationary phase surface.Type: GrantFiled: January 24, 2022Date of Patent: April 16, 2024Assignee: SIELC Technologies CorporationInventor: Yury Zelechonok
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SEC performance enhancing conditioning and storage solvents containing low levels of buffer and salt
Patent number: 11951417Abstract: This disclosure pertains to performance enhancing conditioning and storage solvents containing low levels of buffer and salt for reproducible and improved size exclusion chromatography (SEC). In some embodiments, the present disclosure pertains to storage solvents for protein-based size exclusion chromatography that include water, a water-miscible organic solvent, a phosphate salt, and a neutral salt. In some embodiments, the present disclosure pertains to columns for protein-based size exclusion chromatography that include porous particles and such a storage solvent.Type: GrantFiled: April 15, 2021Date of Patent: April 9, 2024Assignee: Waters Technologies CorporationInventors: Pamela C. Iraneta, Stephen James Shiner, Raymond P. Fisk, Lavelay Kizekai -
Patent number: 11938418Abstract: Certain embodiments of the invention provides a method for monitoring level of saturation of a chromatography media in a column, which method comprises measuring a first pressure at the inlet of an unloaded column; measuring a second pressure at the inlet from a loaded column; and comparing the first and second pressure measurement to determine the level of saturation of the chromatography media. Embodiments of the invention also provide related methods for controlling a chromatography system and methods for controlling a periodic counter current chromatography system, as well as a chromatography system suitable for use with the novel methods.Type: GrantFiled: December 15, 2015Date of Patent: March 26, 2024Assignee: Cytiva Sweden ABInventor: Karol Maciej Lacki
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Patent number: 11938464Abstract: A chromatography column for the use of separation of acidic sugar chains, wherein the column comprises a first column and a second column, the second column connected by a flow path downstream of an outlet of the first column, and selected from the following (1) or (2): (1) the carrier of the first column is hydrophobically modified silica having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine; (2) the carrier of the first column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is hydrophobically modified silica having a group containing a primary amine, a secondary amine, or/and a tertiary amine.Type: GrantFiled: December 29, 2022Date of Patent: March 26, 2024Assignee: JCR Pharmaceuticals Co., Ltd.Inventors: Tomoki Fukatsu, Chika Morooka
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Patent number: 11938462Abstract: A method of preparing an adsorbent can include pyrolyzing palm fiber to provide an palm fiber char, activating the palm fiber char, dissolving at least one polymer in an organic solvent to obtain a solution, dispersing the activated palm fiber char in the solution to provide a mixture, extracting the solvent from the mixture to provide a composite, and annealing the composite to provide the adsorbent. The adsorbent can be porous.Type: GrantFiled: October 11, 2023Date of Patent: March 26, 2024Assignee: KING FAISAL UNIVERSITYInventors: Junaid Saleem, Sk Safdar Hossain, Zubair Khalid Baig Moghal, Gordon McKay
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Patent number: 11931719Abstract: The invention discloses a functionalised chromatography medium, comprising: i) at least one non-woven layer (10) of polymeric nano fibres (20) comprising a plurality of nanofibre-nano fibre fusion points (30); ii) a grafted polymer coating covering the polymeric nanofibres and the nanofibre-nanofibre fusion points; iii) a plurality of ligand groups covalently bound to the grafted polymer coating, wherein the ligand groups are capable of interacting with a target biomolecule.Type: GrantFiled: January 7, 2019Date of Patent: March 19, 2024Assignee: PURIDIFY LTD.Inventors: Marc Hummersone, Benjamin Wallis, Frederic Leroux, William Howard Albert Law
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Patent number: 11927573Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.Type: GrantFiled: January 25, 2021Date of Patent: March 12, 2024Assignee: CYTIVA BIOPROCESS R&D ABInventor: Klaus Gebauer
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Patent number: 11921095Abstract: A method of mass spectrometry is disclosed comprising repeatedly or continuously causing first analyte sample to be released or ejected from a first sample. A determination is made as to whether or not a quality threshold such as an intensity threshold has been met or exceeded, wherein if the quality threshold has been met or exceeded then the method further comprises repeatedly or continuously causing second analyte sample to be released or ejected from a second sample.Type: GrantFiled: October 13, 2020Date of Patent: March 5, 2024Assignee: Micromass UK LimitedInventors: Gareth Rhys Jones, Michael McCullagh, Alastair Murray Booth
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Patent number: 11913685Abstract: Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium.Type: GrantFiled: October 20, 2021Date of Patent: February 27, 2024Assignee: Supercritical Fluid Technologies, Inc.Inventors: Kenneth Joseph James, Brian Jeffrey Waibel, Kenneth Richard Krewson, Kim Ferrara, Curtis Ebersold
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Patent number: 11904258Abstract: Thermal isolation chambers that can be used to heat or cool a chromatography column are described. Certain configurations include at least one plate and an insulative barrier. The plate and insulative barrier can form a cyclical air flow path such that air in the cyclical air flow path can be provided to a chromatography column to remove heat from the chromatography column. The heat can be transferred to the plate. Systems including the thermal isolation chambers, and methods of using the thermal isolation chambers to perform chromatographic separations are also described.Type: GrantFiled: September 28, 2020Date of Patent: February 20, 2024Assignee: PerkinElmer U.S. LLCInventors: Chad Kingston, Nathan L Porter, Benjamin J. Black
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Patent number: 11878261Abstract: The present disclosure relates to a method for making a ceramic mini-tube configured for use in a fluid modification system. The method involves using an electrospinning system to receive a quantity of precursor solution. The electrospinning system creates an electric field which causes the precursor solution, when emitted, to be stretched into a fiber jet. The fiber jet is deposited on a collector resulting in a fiber mat. The fiber mat is removed from the collector, wherein the fiber mat is formed into a shape. The fiber mat is further processed so that the fiber mat retains a desired shape. A heat treatment operation is then performed to convert the fiber mat into a ceramic structure having the desired shape.Type: GrantFiled: June 14, 2022Date of Patent: January 23, 2024Assignee: Lawrence Livermore National Security, LLCInventors: James Patrick Kelly, Jeffery J. Haslam, Mark Mitchell
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Patent number: 11867670Abstract: Disclosed is a continuous process in which a subset of a number of mutually identical columns, are connected in series. The process liquid, e.g. crude cell culture harvest, is supplied to the most upstream column of the subset. It flows successively through the in series connected columns and leaves the subset through the most downstream and flows into the downstream collection vessel. As soon as the packed bed of the most upstream column is become saturated with product, this column is disconnected from the subset. It is removed from the series connection. A replacement, identical, column is added such that it is connected in series downstream from the most downstream column of the subset. This process is repeated.Type: GrantFiled: January 22, 2019Date of Patent: January 9, 2024Assignee: PROXCYS HOLDING B.V.Inventor: Marcellus Johannes Hubertus Raedts
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Patent number: 11850571Abstract: This disclosure provides polyamine sorbent compositions for the separation of metals from aqueous solutions. The polyamine sorbent compositions comprise a silica support, an aminosilane bound to the silica support, an epoxysilane bound to the silica support, and a polyamine where the polyamine is chemically tethered onto a solid silica support through via the epoxysilane. The polyamine may be further stabilized within the bulk sorbent through hydrogen bonding interactions with the aminosilane. The sorbent compositions resist leaching by H2O in an aqueous stream containing heavy oxyanion-based (and other) metals and demonstrate stability over a pH range of 2-14. The sorbent compositions are useful for the separation of metals from aqueous solutions. The cationic heavy metals are captured by the co-existing amine groups (—NH2, —NH, —N) from the polymeric network while additional metal capture capacity is derived from the introduction of a secondary silane linker.Type: GrantFiled: July 20, 2020Date of Patent: December 26, 2023Assignee: United States Department of EnergyInventors: McMahan L Gray, Brian W. Kail, Walter Christopher Wilfong, Qiuming Wang, Fan Shi
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Patent number: 11845059Abstract: A chromatographic cassette includes a cassette including a chamber, chromatographic media disposed within the cassette chamber, a distribution network fluidly coupled to the chromatographic media and an inlet port and an outlet port coupled to the distribution network. A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.Type: GrantFiled: July 22, 2022Date of Patent: December 19, 2023Assignee: SPF TECHNOLOGIES LLCInventor: Gaston de los Reyes
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Patent number: 11841350Abstract: A dynamic axial compression column is disclosed herein. This dynamic axial column utilized external compression to prevent the creation of end plate space in the column. The dynamic axial column can include a tube defining a first opening, a second opening, and a lumen extending there between. The dynamic axial column can include a first end plate assembly sealing the first opening and movably extending at least partially into the lumen via the first opening, a second end plate assembly sealing the second opening, a plurality of rods extending along the outside of the tube and connecting the first end plate assembly and the second end plate assembly, and a first plurality of compression devices external to the tube and engaging one of the plurality of rods to bias the first end plate assembly towards the second end plate assembly.Type: GrantFiled: March 15, 2022Date of Patent: December 12, 2023Assignee: Bio-Rad Laboratories, Inc.Inventors: Christopher Belisle, Mark A. Snyder
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Patent number: 11839835Abstract: A simulated moving-bed type chromatographic separation method separating a weakly adsorptive component, a strongly adsorptive component, and an intermediately adsorptive component, with eluents by using a circulation system in which a plurality of unit packed columns packed with an adsorbent are connected in series and in an endless form via pipes in which a feed solution supply port F, two or more eluent supply ports D corresponding to the eluents, an extraction port A of a fraction containing the weakly adsorptive component, an extraction port B of a fraction containing the intermediately adsorptive component, and an extraction port C of a fraction containing the strongly adsorptive component are provided in the pipes of the circulation system, and positions of the ports F, A, B, and C are set to have a specified relationship.Type: GrantFiled: October 8, 2019Date of Patent: December 12, 2023Assignee: ORGANO CORPORATIONInventors: Kazuo Okada, Masahiro Ogino, Kohei Sato, Masaki Tsuruta, Toshiki Miyajima