Abstract: Interventional catheter assemblies, operating systems and adaptive interface components allow operation of a variety of interventional catheter assemblies, including infusion catheters, aspiration catheters and interventional catheters that provide both infusion and aspiration, using a common control console housing infusion and aspiration systems. Control instructions for operating the interventional catheter assembly and authentication protocols for verifying system matches and operating conditions maybe encoded in hardware, firmware or software, such as a memory or storage device, provided in the interventional catheter assembly or in a discrete adaptive interface component. Adaptive components such as tubing cassettes routing aspiration and/or infusion tubing in a predetermined configuration to mate with aspiration and infusion systems on a control console are also provided.