Abstract: Disclosed are cationic polymers comprising monomers such as those described in Formula (I). Such polymers can be useful for the preparation of therapeutic compositions [e.g., compositions comprising nucleic acids such as m RNA). Additionally, therapeutic compositions comprising these cationic, biodegradable polymers can have improved properties and reduced toxicity.

Abstract: This invention is directed to methods for prevention of infections by highly pathogenic viruses by applying to the nasal mucous membranes topical preparations comprising the broad-spectrum antimicrobial agent povidone-iodine.

Abstract: A water-in-oil emulsion composition that is significantly excellent in emulsification stability, and also excellent in non-stickiness is provided. The water-in-oil emulsion composition includes (a) a polyoxyalkylene/alkyl co-modified silicone; (b) a core-corona particle; (c) an oil-phase component; and (d) an aqueous-phase component.

Abstract: The instant disclosure is directed to compositions comprising an encapsulated spheroid, and methods of making and using the same. A composition may comprise a spheroid comprising a plurality of cells and aminoglycoside antibiotic-derived hydrogel beads, wherein the spheroid is encapsulated by the aminoglycoside antibiotic-derived hydrogel beads to form an encapsulated spheroid. A method may comprise administering the composition to a subject in need thereof. Another method may comprise administering a compound to the encapsulated spheroid. A method of creating an encapsulated spheroid may comprise coating a surface with an aminoglycoside antibiotic-derived hydrogel, culturing a plurality of cells on the surface, thereby creating a spheroid, and encapsulating the spheroid with a plurality of aminoglycoside antibiotic-derived hydrogel beads.

Abstract: The present invention provides a method of inhibiting tolerance to an opioid by a human subject in need thereof. The method comprises administering an effective amount of a pharmaceutical composition to the subject during opioid therapy. The pharmaceutical composition comprises a) a non-steroidal anti-inflammatory drug (NSAID); and b) a co-agent selected from the group consisting of: fexofenadine, ketotifen, desloratadine, cetirizine, salts thereof and combinations thereof.

Abstract: A clear personal cleansing composition having an anionic surfactant, a cationic deposition polymer, an aqueous carrier and a level of inorganic salt of from about 0 to about 1 wt %. The composition is substantially free of sulfates and has a % T of greater than about 80%. The composition can further comprise amphoteric surfactants. The composition remains phase stable and minimizes coacervate formulation until after dilution with water.

Abstract: A universal mineral based sunscreen that is good for all skin colors and prevents any ashy visual appearance on all colors of skin.

Abstract: A sunscreen comprises red iron oxide and a mineral sunscreen blend, that is universal with all skin colors and prevents ashy skin.

Abstract: Disclosed is agents and methods that target metabolism malfunctions, inborne as well as acquired, as well as methods for preparation of the agents. In particular, the invention relates to methods for preparing molecular imprinted polymers with high binding capacity for phenylalanine or tyrosine, MIPs that bind phenylalanine or tyrosine, and methods for treating phenylketonuria, alkaptonuria, and hypertyrosinemia.

Abstract: The present invention provides a preparation for attaching to teeth or tooth peripheries. The preparation for attaching to teeth or tooth peripheries of the present invention can give high adhesive force to the desired site despite interproximal space or curves of teeth. It is easy to hand while controlling drug release.

Abstract: An antimicrobial article that includes: an antimicrobial composite region that includes a matrix comprising a polymeric material, and a first plurality of particles within the matrix. The particles include a phase-separable glass with a copper-containing antimicrobial agent. The antimicrobial composite region can be a film containing the first plurality of particles that is subsequently laminated to a bulk element. The first plurality of particles can also be pressed into the film or a bulk element to define an antimicrobial composite region. An exposed surface portion of the antimicrobial composite region can exhibit at least a log 2 reduction in a concentration of at least one of Staphylococcus aureus, Enterobacter aerogenes, and Pseudomonas aeruginosa bacteria under a Modified EPA Copper Test Protocol.

Abstract: The invention relates to cosmetic compositions comprising certain polyethers, polyether derivatives (e.g., polymeric alcohols and derivatives thereof), and methods of making and using the same, specifically in the field of cosmetic or personal care compositions applied to the skin or the hair.

Abstract: A composition for lubricant formulations is disclosed. The composition may include hypochlorite, dimethicone, and an emulsifier for improvement of lubricity. Methods of making and using the lubricant formulations are also disclosed.

Abstract: At least one embodiment, relates to a method for making cosmetic emulsions comprising the steps of preparing a uniform (suspension) dispersion of at least one water soluble polymer in a mixture containing at least one fatty alcohol. The mixture is to be sufficiently uniform to be processed by flaking, pastillating, prilling or otherwise solidifying the mixture which is then to be added to a cosmetic emulsion oil phase before combining with a water phase.

Abstract: The present invention relates to a composition in the form of an O/W emulsion, comprising: (a) at least one cationic polysaccharide; (b) at least one crosslinker having three or more acid groups or salt thereof; (c) at least one oil; and (d) water, wherein the amount of the (c) oil(s) in the composition is 50% by weight or more, preferably 60% by weight or more, and more preferably 70% by weight or more, relative to the total weight of the composition. The composition in the form of an O/W emulsion according to the present invention is stable. Also, a composition in the form of an O/W/O emulsion can be prepared by the composition in the form of an O/W emulsion according to the present invention.

Abstract: The present application relates to a polymer composition, a film-forming agent, a cosmetic composition and a method of preparing a polymer composition. The present application is directed to providing a polymer composition, which has excellent oil resistance and is capable of forming a cosmetic or the like that has no smudging and no powder flaking during use and a film-forming agent and a cosmetic manufactured using the same.

Abstract: The present patent application is directed to compositions and shaped structures implantable into mammalian bodies, the compositions and shaped structures having localized bioactive surfaces.

Abstract: A water-rinsable, aqueous cleansing formulation may include a cosmetic oily component. The formulation may foam and remain stable despite the presence of a cosmetic oily component, even when the oily component is present in potentially substantial amounts.

Abstract: Provided is a cleansing foam cosmetic composition comprising amino acid-based surfactants, and more particularly to a cleansing foam cosmetic composition in which a nonionic or amphiprotic surfactant is not used, and which comprises amino acid-based surfactants consisting of only sodium lauroyl glutamate, sodium cocoyl glycinate, and potassium cocoyl glycinate.

Abstract: Disclosed are oral care compositions of phosphonate and sulfonate group containing polymer compositions that have targeted uses with divalent cations and surfaces having divalent cations. These compounds can be used to deliver anionic character to surfaces such as calcium hydroxyapatite.