Abstract: Disclosed is an osmotic pharmaceutical delivery system comprising (a) a semipermeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough; (b) a single, homogeneous composition within said wall, which composition consists essentially of (i) a pharmaceutically active agent, (ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutically active agent; (iii) at least one non-swelling osmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition which enhances the surface area contact of the pharmaceutical agent with the incoming aqueous fluid.
Type:
Grant
Filed:
July 11, 2000
Date of Patent:
September 4, 2001
Assignee:
Shire Laboratories, Inc.
Inventors:
Edward M. Rudnic, Beth A. Burnside, Henry H. Flanner, Sandra E. Wassink, Richard A. Couch, Jill E. Pinkett
Abstract: A controlled release pharmaceutical tablet containing antihyperglycemic drug and a hypoglycemic drug that does not contain an expanding or gelling polymer layer and comprising a core containing the antihyperglycemic drug and the hypoglycemic drug, a semipermeable coating membrane surrounding the core and at least one passageway in the membrane to allow the drugs to be released from the core.
Type:
Grant
Filed:
June 9, 2000
Date of Patent:
September 4, 2001
Assignee:
Andrx Pharmaceuticals, Inc.
Inventors:
Chih-Ming Chen, Xiu Xiu Cheng, Joseph Chou, Steve Jan
Abstract: The invention provides a micronized fenofibrate composition. The micronized fenofibrate composition has a dissolution of at least 10% in 5 minutes, 20% in 10 minutes, 50% in 20 minutes and 75% in 30 minutes, as measured using the rotating blade method at 75 rpm according to the European Pharmacopoeia, in a dissolution medium constituted by water with 2% by weight polysorbate 80 or with 0.025M sodium lauryl sulfate. The composition can further comprise hydrophilic polymers, surfactants, hydrosoluble carriers, outer phases or layers, or other pharmaceutically acceptable excipients. The immediate-release fenofibrate composition is preferably in the form of a tablet or in the form of granules inside a capsule.
Abstract: Improved conditioning performance from a surfactant-based shampoo composition can be achieved by the inclusion in the shampoo composition of a specific combination of silicones, namely amino functionalised silicone and high viscosity non-amino functionalised silicone. Accordingly, the invention provides an aqueous shampoo composition comprising, in addition to water:
i) at least one surfactant chosen from anionic, nonionic, zwitterionic or amphoteric surfactants or mixtures thereof;
ii) an amino functionalised silicone; and
iii) emulsified particles of an insoluble, non-amino functionalised silicone, in which the viscosity of the silicone itself is at least 500,000 cst, preferably at least 1,000,000 cst.
Abstract: Preparations comprising a capsule, tablet or other dosage form containing a core of different types of DFMO are provided. These preparations are capable of providing for the direct and constant delivery of DFMO to the entire GI tract or just the colon and rectum. The DFMO-containing granules include granules specially formulated to achieve rapid DFMO release, and granules formulated to achieve slower DFMO release and/or granules formulated for gastric, enteric or colorectal release. Methods of using the preparations to flood the GI tract with relatively constant levels of DFMO may thus be provided. The ratio of the (+) to the (−)-enantiomeric forms of DFMO in the granules will be controlled so as to enhance the pharmacological profile and reduce toxicity of the preparation relative to racemic DFMO. Preparations and methods for achieving systemic delivery as well as direct colon delivery of DFMO are also described.
Abstract: The present invention relates to a compressed, chewable tablet containing at least one active ingredient, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and compressed into convex-shaped tablet having a hardness of about 2 to about 11 kp/cm2 and friability less than 1%.
Type:
Grant
Filed:
August 18, 1998
Date of Patent:
August 7, 2001
Assignee:
MxNeil-PPC, Inc.
Inventors:
Ronni L. Robinson, James R. Damon, James R. Mossop, Michael D. Palmer
Abstract: A once-a-day controlled release formulation of a water soluble drug is described which includes:
(a) from 20 to 50% by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of a water soluble drug and a binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and
(b) from 50% to 80% by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of a water soluble drug and a binder and a second layer which comprises a polymeric membrane and a alkaline earth metal stearate which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to said water soluble drug; and
(c) a unit dose containment system.
Abstract: This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.
Abstract: A 2-in-1 conditioning shampoo includes an anionic surfactant and a cationic hair conditioning agent. The cationic hair conditioning agent is a fatty aliphatic quaternary ammonium compound having ester linkages. The cationic hair conditioning agent can be prepared by reacting an alkanol amine with a fatty acid or fatty acid ester having an aliphatic group of from about 11 to about 24 carbon atoms and thereafter quaternizing the resulting esteramine with an alkylating agent.
Type:
Grant
Filed:
May 10, 1999
Date of Patent:
July 24, 2001
Assignee:
Akzo Nobel nv.
Inventors:
Ralph Franklin, Paul Iacobucci, Dale Steichen, Diana Tang, Phuong-Nga Trinh
Abstract: A transdermal device is described suitable for delivery of a pharmaceutical to the systemic circulation through de-epithelialized skin. In its various embodiments the device includes means to prevent the attack of any protein or polypeptide active agent included therein by proteolytic enzymes which exude from the lesion, means to prevent the ingress of bacteria and other cellular debris from the lesion and means to ensure that substantially all said active agent is directed to the de-epithelialized lesion.
Abstract: The invention provides compositions for mending split ends of keratinous fibers, particularly human hair. The compositions of the present invention contain guar, a betaine based polyurethane surfactant and a silicone polyurethane.
Abstract: Provided by the invention is a film-forming silicone-based composition suitable as an additive ingredient in toiletry or cosmetic preparations or, in particular, in hair care treatment compositions such as shampoos to impart the treated hair with excellent glossiness and slipperiness along with excellent water and perspiration resistance. The composition comprises (A) a diorganopolysiloxane of a high degree of polymerization having fluorinated alkyl groups, optionally, in combination with amino- or ammonium-containing organic groups and (B) an oily constituent selected from (B1) a linear diorganopolysiloxane of a relatively low degree of polymerization, (B2) a cyclic diorganosiloxane oligomer and (B3) an isoparaffin oil having a specified boiling point. The silicone-based composition is formulated in a toiletry preparation together with a surface agent and water and/or ethyl alcohol.
Abstract: Sustained release drug formulations contain the pharmaceutical itself and a three component release rate controlling matrix composition. The three components of the matrix composition are (1) water insoluble polymer, such as ethyl cellulose, (2) pH dependent gelling polymer, such as sodium alginate, and (3) a pH independent gelling polymer, such as hydroxypropyl methylcellulose. The drug release rate can be adjusted by changing the amount of one or more of these components of the composition.
Type:
Grant
Filed:
February 4, 1998
Date of Patent:
June 26, 2001
Inventors:
Guohua Zhang, Prasad Pinnamaraju, Muhammad A. Ali
Abstract: The invention relates to a process for improving the color fastness of a dyed keratin fiber comprising applying to said fiber (a) at least one dye composition containing, in a medium suitable for dyeing, at least one oxidation base selected from bis(phenyl)alkylenediamines, para-aminophenols, ortho-aminophenols, heterocyclic bases and para-phenylenediamines of formula (I), and the addition salts of these compounds with an acid:
in which:
R1 represents a hydrogen atom or a C1-C4 alkyl, C1-C4 monohydroxyalkyl, C2-C4 polyhydroxyalkyl, phenyl or 4′-aminophenyl radical, R2 represents a hydrogen atom or a C1-C4 alkyl, C1-C4 monohydroxyalkyl or C2-C4 polyhydroxyalkyl radical, R3 represents a hydrogen atom, a halogen atom, or a C1-C4 alkyl, C1-C4 monohydroxyalkyl or C1-C4 hydroxyalkoxy radical, and R4 represents a hydrogen atom or a C1-C4 alkyl radical, and (b) developing the color at acidic, neutral or alkaline pH using an oxidizing agent, wherein said oxidizing agent is added to said dye co
Abstract: A composition, particularly adapted for oral administration, containing omeprazole, and a method for preparing the composition, are disclosed. The composition, being exempt of alkaline-reacting compounds, contains a core constituted of nuclei and said benzimidazole, the nuclei and benzimidazole being compressed together, an intermediate layer, and an enteric layer.
Abstract: The invention relates to a hair dye composition comprising (A) an acid dye and (B) an alkylene carbonate having 3-5 carbon atoms in total, said composition exhibiting a pH of 2-6, and having a buffer capacity of 0.007-0.5 gram equivalent/L, and to a method of dyeing hair using the hair dye composition. The hair dye composition is excellent in hair-dyeing ability without coloring the scalp and skin and has good fastness to shampoo and the like.
Abstract: Disclosed are hair shampoo compositions which provide cleaning and styling performance, and which contain latex polymer particles, water-soluble cationic polymer as a latex deposition aid, organic oil as a latex deposition aid, and typically one or more surfactants, an aqueous carrier and one or more optional ingredients. The organic oil is a hydrocarbon oil or fatty ester, and is present in an amount effective to enhance deposition of the latex polymer particles onto hair in the presence of cationic polymer.
Type:
Grant
Filed:
June 23, 2000
Date of Patent:
June 19, 2001
Assignee:
The Procter & Gamble Company
Inventors:
Sharon Ann Young, Michael Albert Snyder
Abstract: The present invention relates to leave-on hair styling compositions comprising from greater than 0.5% to about 5% of a water soluble, non-polymeric mineral salt, from about 0.05% to about 0.5% of a lipophilic material, from about 0.01% to about 0.5% of a surfactant, and an aqueous carrier. The surfactant is selected from the group consisting of amphoteric surfactants, anionic surfactants, and nonionic surfactants having the formula
or R1R2R3Z→O, and mixtures thereof. The compositions comprise less than 0.01% cationic surfactant, less than about 0.2% of a chemical protein modifying agent, less than 0.01% formate, sorbate, salicylate and carbonate compounds, and less than about 0.2% of a polymer having a solubility parameter of from about 8.5 to about 12.0 (cal/cm3)½. Further, the composition has a hair friction index of at least 1.07.
Abstract: A method of protecting hair or wool against thermal degradation when heat treated at 100-180° C. which comprises applying a composition which includes methyl vinyl ether-maleic acid copolymer as an active constituent to said hair or wool.
Type:
Grant
Filed:
June 22, 1999
Date of Patent:
June 5, 2001
Assignee:
ISP Investments Inc.
Inventors:
Roger L. McMullen, Jr., Janusz Jachowicz
Abstract: The present invention relates to non-spherical and/or non-platelet pyrithione particles. Also disclosed is a method for producing non-spherical and/or non-platelet particles of pyrithione salts, comprising reacting pyrithione acid or a water-soluble salt of pyrithione and a water-soluble polyvalent metal salt in the presence of an ionic surfactant composition at temperature from about 20° C. to about 60° C. and at a pH from 4-9 to produce non-spherical and/or non-platelet particles of pyrithione salts. The present invention further relates to particles made by the above methods and products, such as shampoos, soaps, and skin-care medicaments made using these particles.
Type:
Grant
Filed:
October 1, 1999
Date of Patent:
June 5, 2001
Assignee:
Arch Chemicals, Inc.
Inventors:
Saeed H. Mohseni, John J. Jardas, George Polson, David C. Beaty, Charles W. Kaufman