Abstract: A computer based system and method of visualizing a region using multiple image data sets is provided. The method includes acquiring first volumetric image data of a region and acquiring at least second volumetric image data of the region. The first image data is generally selected such that the structural features of the region are readily visualized. At least one control point is determined in the region using an identifiable structural characteristic discernable in the first volumetric image data. The at least one control point is also located in the at least second image data of the region such that the first image data and the at least second image data can be registered to one another using the at least one control point. Once the image data sets are registered, the registered first image data and at least second image data can be fused into a common display data set.

Abstract: A fluorescent-light image obtaining apparatus for obtaining an autofluorescent-light image emitted from a target tissue irradiated by an excitation light, wherein the safety of the patient is ensured against injury from exposure to excessive excitation light when the distance between the output end of the excitation light projector and the target tissue is short. A contact detector detects that the end of the excitation light projector of the endoscope is in contact with the target tissue. Then, an excitation light output controller receives a signal indicating that the end of the excitation light projector is in contact with the target tissue. In response to this signal, the excitation light output controller stops the emission of the excitation light, or reduces the intensity of the emitted excitation light to a safe intensity for the patient even while the end of the excitation light projector and the target tissue are in contact.

Abstract: The invention provides a means to produce reconstructed refractive index spatial maps that reveal and allow visual separation of normal soft tissue and certain types of tumors. Detector fiber optic bundles positioned on the surface of a soft tissue organ receive and transmit scattered light data, from light in the near-infrared portion of the spectrum delivered to the surface of the organ by separate fiber optic bundles to a computer. Based on an established grid and certain assumed values, the data are analyzed by means of a complex algorithm to produce calculated refractive index values. Through iteration, the values are recalculated to minimize the difference between the observed scattering and calculated values to yield a stable map indicating spatial variation in refractive index and such variation in the form of displayed images indicates the presence of tumors in normal soft tissue.

Abstract: A medical system is disclosed that includes a cannula, an introducer stylet removably disposed within the cannula and a target confirmation device selectively insertable within the cannula. In an embodiment of the invention, the introducer stylet is configured for insertion into a patient's body. The outer cannula is sized to fit over the introducer stylet and is positionable at least partially within the patient's body after insertion and removal of the introducer stylet. The target confirmation device is insertable into the outer cannula after removal of the introducer stylet and is configured to confirm the position of the outer cannula relative to the target site. A medical procedure using the medical system of the present invention is also disclosed.

Abstract: A methodology and system for lysing adipose tissue including directing ultrasonic energy at a multiplicity of target volumes within the region, which target volumes contain adipose tissue, thereby to selectively lyse the adipose tissue in the target volumes and generally not lyse non-adipose tissue in the target volumes and computerized tracking of the multiplicity of target volumes notwithstanding movement of the body.

Abstract: This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as amplitude, pulsewidth, frequency, pulse morphology, electrode contact selection or location, return path electrode selection, pulse polarity, etc. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, the non-uniform tissue conductivity is obtained from diffusion tensor imaging (DTI) data. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence.

Abstract: Body temperature measurements are obtained by scanning a thermal radiation sensor across the side of the forehead over the temporal artery. A peak temperature measurement is processed to compute an internal temperature of the body as a function of ambient temperature and the sensed surface temperature. The function includes a weighted difference of surface temperature and ambient temperature, the weighting being varied with target temperature through a minimum in the range of 96° F. and 100° F. The radiation sensor views the target surface through an emissivity compensating cup which is spaced from the skin by a circular lip of low thermal conductivity.

Abstract: In one example, an illumination system is provided in an MRI system including an open MRI assembly comprising a pole covered by a canopy. The MRI system is within a shielded room. A light source is provided outside of the shielded room, at least one light projector is connected to the canopy, and optical fibers couple the light source to the light projector. The light projector is preferably flexible. The light projector or projectors increase the illumination in the imaging volume, facilitating medical procedures conducted on a subject within the imaging volume.

Abstract: A method for planning biventricular pacing lead placement for a patient includes obtaining acquisition data from a medical imaging system and generating a 3D model of the left ventricle and thoracic wall of the patient. One or more left ventricle anatomical landmarks are identified on the 3D model, and saved views of the 3D model are registered on an interventional system. One or more of the registered saved views are visualized with the interventional system, and at least one suitable region on the left ventricle wall is identified for epicardial lead placement.

Abstract: A 3D projection reconstruction pulse sequence is employed during a CEMRA dynamic study to acquire a time course series of k-space data sets. Signals from non-vascular voxels are suppressed by reconstructing a corresponding series of low resolution images using the centers of the acquired k-space data sets, and measuring the degree to which the signal behavior of voxels therein differ from a model of unwanted signal. Signals from voxels which do not differ from the model are suppressed and the resulting filtered low resolution images are transformed back to k-space and combined with the originally acquired peripheral k-space data to form complete, filtered k-space data sets from which images may be reconstructed.

Abstract: In one aspect, a restraining assembly for an awake animal within a magnetic resonance imaging (MRI) device is provided and includes a body restrainer having a first part and a second part that hold a body of the awake animal therebetween. The assembly is of a dual coil design in that it has a volume coil for generating an excitation RF signal and an RF surface coil for receiving an RF response from the animal. The assembly further includes components that serve to restrain movements of the animal, thereby eliminating motion artifacts during the MRI procedure.

Abstract: A method is disclosed for analyzing body composition. The method includes inducing a static magnetic field in the body. The static magnetic field has a known distribution along a longitudinal axis of the body. A radio frequency magnetic field is induced in the body. The radio frequency and a bandwidth thereof are selected to induce nuclear magnetic resonance phenomena in a selected axial segment along the body. Nuclear magnetic resonance phenomena are from the selected axial segment. Composition is determined from the magnetic resonance signals. The measurement may be repeated in different axial segments by changing the static field amplitude or a frequency of the RF magnetic field. In some embodiments, a gradient field is superimposed over the static field.

Abstract: Medical imaging and navigation system including a processor, a medical positioning system (MPS), a two-dimensional imaging system and an inspected organ monitor interface, the MPS including an imaging MPS sensor, the two-dimensional imaging system including an image detector, the processor being coupled to a display unit and to a database, the MPS being coupled to the processor, the imaging MPS sensor being firmly attached to the image detector, the two-dimensional imaging system being coupled to the processor, the image detector being firmly attached to an imaging catheter.

Abstract: In a method and apparatus for generating an image from magnetic resonance signals, two image matrices generated from magnetic resonance signals are added to or subtracted from one another pixel-by-pixel, to generate a further image therefrom. The magnitude added or subtracted for each picture element is formed by multiplication of a magnitude value of the second image matrix by a weighting factor. The weighting factor is dependent on the magnitude value of the second image matrix such that it is higher given a high magnitude value than for a low magnitude value. The magnitude noise is decreased compared to a linear addition or subtraction, and uncontrolled signal reductions are avoided. An exponent in the power of the magnitude value of the second image matrix a signal-dependent weighting factor can be set at an input device.

Abstract: An ultrasound system is provided comprising an ultrasound probe having a 2D matrix of transducer elements transmitting a continuous wave (CW) Doppler transmit signal into an object of interest. The CW transmit signal includes a dither signal component and the probe receives ultrasound echo signals from the object in response to the CW transmit signal. The probe generates an analog CW receive signal based on the ultrasound echo signals. An analog to digital (A/D) converter converts the analog CW receive signal to a digital CW receive signal at a predetermined sampling frequency and a processor processes the digital CW receive signal in connection with CW Doppler imaging.

Abstract: A method for detecting breast cancer can include the step of positioning a transmitting antenna and a receiving antenna about a breast so that the transmitting antenna is positioned to transmit microwave energy into the breast and the receiving antenna is positioned to receive the transmitted energy after the energy has passed into the breast. Microwave energy can be transmitted from the transmitting antenna. The microwave energy can be received by the receiving antenna and used to determine a presence of tumors within the breast. A relative position of the transmitting antenna and the receiving antenna can be adjusted about the breast. After each position adjustment, the transmitting and the receiving steps can be repeated.

Abstract: A biomagnetic field measuring apparatus for performing (1) processes for removing a magnetic field waveform generated by a maternal heart from a waveform of a biomagnetic field measured, (2) processes for obtaining a template waveform of a magnetic field waveform generated by the fetal heart from a waveform, from which the magnetic field waveform generated by the maternal heart has been removed, (3) processes for obtaining a waveform of a cross correlation coefficient between the waveform, from which the magnetic field waveform generated by the mother's hears was removed, and the template waveform, and (4) a process for detecting peaks from a waveform of the cross correlation coefficient, and displaying times of appearance of the detected peaks on a display unit.

Abstract: A medical apparatus has a data processing device for storing an image dataset of the body of a subject and a navigation system for determining the position of a medical instrument relative to the body of the subject. At least one bone fragment is shown in the image represented by the image dataset, the image of the one bone fragment being segmented with a computer. The bone fragment is to be grasped and set with the medical instrument. The data processing device also determines the modified position of the bone fragment on the basis of the position of the medical instrument relative to the body of the subject determined with the navigation system, and displays the modified position in the image.

Abstract: Systems and methods deliver ultrasound energy to an ultrasound transducer having an impedance subject to variations. The systems and methods electrically couple an ultrasound generator to the ultrasound transducer to deliver ultrasound energy. The systems and methods deliver ultrasound energy to the ultrasound transducer at a set output frequency and at an output power level that remains essentially constant, despite variations in the impedance, based upon preprogrammed rules.

Abstract: An apparatus includes an optical element, a GRIN lens, and a detector. The optical element has a first optical aperture. The GRIN lens has first and second ends. The first end of the GRIN lens is positioned to receive light from the first optical aperture. The detector is configured to measure values of a characteristic of light emitted from the first end in response to multi-photon absorption events in a sample illuminated by light from the second end of the endoscopic probe.