Patents Examined by Bruce Gray
  • Pentamidine salts useful in the treatment of pneumocystis carinii pneumonia
    Patent number: 5084480
    Abstract: Salts of pentamidine, formulations containing such salts and the use of such salts of treatment or prophylaxis of pneumocystis carinii. Pentamidine gluconate and lactate has been discovered and found to have high water solubility while providing potentially less toxic alternatives to pentamidine isethionate, especially for aerosolized administration to patients suffering from acquired immunodeficiency syndrome, AIDS, or AIDS related complex, ARC.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: January 28, 1992
    Assignee: Fujisawa USA, Inc.
    Inventors: Sadanand Pai, Abu S. Alam, John N. Kapoor
  • Selective monomethylation of phenolic compounds
    Patent number: 5082978
    Abstract: Mono-, di- and triphenols are selectively monomethylated by reaction with para-dimethoxybenzene in the presence of a catalytically effective amount of an acid catalyst.
    Type: Grant
    Filed: May 9, 1991
    Date of Patent: January 21, 1992
    Assignee: Rhone-Poulenc Chimie
    Inventors: Michel Gubelmann, Christian Allandrieu
  • Calcium lactate-glycerol adduct, a process for its preparation
    Patent number: 5081150
    Abstract: Calcium lactate-glycerol adduct, a molecular compound of 1 mole of calcium lactate and 2 moles of glycerol, and a process for its preparation are described. The adduct can be used as a calcium donor or auxiliary in pharmacy, cosmetics and the production of foodstuffs.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: January 14, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Bernhard Reul, Walter Petri
  • Preparation of alpha-formylamino nitriles
    Patent number: 5077427
    Abstract: A process for preparing .alpha.-formylamino nitriles of the formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen or unsubstituted or substituted, with substituents which are inert under the reaction conditions, aliphatic or heteroaliphatic radicals with 1 to 10, cycloaliphatic or heterocycloaliphatic radicals with 3 to 6, araliphatic radicals with 7 to 12, heteroaraliphatic radicals with 4 to 12, aromatic radicals with 6 to 10 or heteroaromatic radicals with 3 to 10 carbon atoms, by reacting cyanohydrins of the formula II ##STR2## with the formamide III ##STR3## in the presence of acids, entails adding at least one ammonium salt to the reaction mixture.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: December 31, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Rolf Fikentscher, Michael Kroener
  • Peroxide process for producing n-phosphonomethylglycine
    Patent number: 5077431
    Abstract: A process is provided for producing N-phosphonomethylglycine by the oxidation of N-phosphonomethyliminodiacetic acid with a peroxide to form an intermediate N-phosphonomethyliminodiacetic acid-N-oxide. Thereafter, the N-phosphonomethyliminodiacetic acid-N-oxide is converted to N-phosphonomethylglycine by adding a catalytic amount of a metal selected from the group consisting of iron, zinc, aluminum, vanadium and copper, or a compound selected from the group consisting of water-soluble vanadium compounds, ferrous salts and cuprous salts.
    Type: Grant
    Filed: April 15, 1991
    Date of Patent: December 31, 1991
    Assignee: Monsanto Company
    Inventor: Donald I. Fields, Jr.
  • Biologically active lipids binding membrane receptors
    Patent number: 5077312
    Abstract: Neutral lipids are provided characterized by binding to phorboid and ingenoid receptors. These lipids are found in a wide variety of cellular sources as well as milk and may be isolated by specific extraction and chromatographic procedures. Depending upon the source, the glycerides may be mono- or di-glycerides, wherein the total number of carbon atoms of the fatty acids is in the range of 18 to 26, so that the monoglyceride has a fatty acid of at least 18 carbon atoms, while the di-glyceride has a fatty acid of at least 14 carbon atoms.
    Type: Grant
    Filed: October 26, 1990
    Date of Patent: December 31, 1991
    Assignee: Oncogen
    Inventors: Mohammed Shoyab, George J. Todaro
  • Peroxide process for producing N-phosphonomethylglycine
    Patent number: 5077430
    Abstract: A process is provided for producing N-phosphonomethylglycine by the oxidation of N-phosphonomethyliminodiacetic acid with a peroxide to form an intermediate N-phosphonomethyliminodiacetic acid-N-oxide. Thereafter, the N-phosphonomethyliminodiacetic acid-N-oxide is converted to N-phosphonomethylglycine by adding a catalytic amount of a metal selected from the group consisting of iron, zinc, aluminum, vanadium and copper, or a compound selected from the group consisting of water-soluble vanadium compounds, ferrous salts and cuprous salts.
    Type: Grant
    Filed: April 15, 1991
    Date of Patent: December 31, 1991
    Assignee: Monsanto Company
    Inventor: Donald L. Fields, Jr.
  • Alkaline earth metal salts of oxa polyacid compounds
    Patent number: 5075336
    Abstract: Compounds of general formula ##STR1## in which: M is an alkaline earth metal,R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and i being defined in the description.Medicaments.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: December 24, 1991
    Assignee: Adir et Compagnie
    Inventors: Stanislas Czernecki, Claude Fugier, Yannis Tsouderos
  • Process for producing N-phosphonomethylglycine
    Patent number: 5072033
    Abstract: A process for the production of N-phosphonomethylglycine comprising contacting N-phosphonomethyliminodiacetic acid with a peroxide in the presence of a catalyst selected from the group consisting of the salts and salt complexes of cobalt and vanadium, and an effective amount of a quinone or hydroquinone.
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: December 10, 1991
    Assignee: Monsanto Company
    Inventors: Donald L. Fields, Jr., Raymond C. Grabiak, Karl E. Koenig, Dennis P. Riley
  • Chemical process
    Patent number: 5068421
    Abstract: There is disclosed herein improved processes for the preparation of ether carboxylates by reacting in an alkaline reaction medium the salts of maleic acid and malic acid in the presence of a calcium ion catalyst wherein unreacted acid salts are recovered from the reaction medium by lowering the pH of the reaction medium to a range of from about 4 to about 6 in two steps, the first step ending at a pH in the range of from about 7 to about 8.5. The precipitate is removed and the pH of the reaction medium is then lowered further to a pH in the range of from 4 to 6. The precipitated salts are recycled to the synthesis reaction to prepared additional amounts of product.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: November 26, 1991
    Assignee: Monsanto Company
    Inventor: Liou-Liang Horng
  • Process for the preparation of 2-chloro and 2,6-dichloroanilines
    Patent number: 5068392
    Abstract: 2-Chloro and 2,6-dichloroanilines, optionally substituted in the 3-, 5-, and/or 6-position are prepared from the corresponding anilides by selective bromination, chlorination, reduction and hydrolysis. The selectivity of the process for introducing chlorines ortho to the amino group is very high.
    Type: Grant
    Filed: January 24, 1991
    Date of Patent: November 26, 1991
    Assignee: DowElanco
    Inventors: Lennon H. McKendry, Mark W. Zettler
  • Process for the continuous preparation of glyoxylic acid
    Patent number: 5068417
    Abstract: A process for continuous preparation of a concentrated aqueous solution of glyoxylic acid by hydrolysis of glyoxylic acid ester hemiacetals, wherein glyoxylic acid ester hemiacetals are treated with steam in countercurrent in a reactor cascade.
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: November 26, 1991
    Assignee: Chemie Linz Gesellschaft m.b.H.
    Inventors: Alexander Sajtos, Engelbert Kloimstein, Karl Hollinger, Lorenz Farnlettner
  • Process for producing highly pure 2,6-naphthalene dicarboxylic acid
    Patent number: 5068410
    Abstract: A process for producing highly pure 2,6-napthalene dicarboxylic acid, characterized by hydrolyzing 2,6-dimethyl naphthalene dicarboxylate more than 99% pure in an aqueous solution by using an aromatic poly-carboxylic acid as a catalyst is disclosed.
    Type: Grant
    Filed: November 15, 1990
    Date of Patent: November 26, 1991
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Toru Tanaka, Masato Inari
  • Process for the preparation of aromatic aldehydes
    Patent number: 5068450
    Abstract: A process for the preparation of aromatic aldehydes by formylation of aromatic compounds in liquid hydrofluoric acid in the presence of boron trifluoride.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: November 26, 1991
    Assignee: Rhone-Poulenc Chimie
    Inventors: Michel Crochemore, Christophe Rochin
  • Separation of lactic acid from fermentation broth with an anionic polymeric absorbent
    Patent number: 5068418
    Abstract: Lactic acid is separated from a fermentation broth by using an adsorbent comprising a water-insoluble macroreticular or gel weakly basic anionic exchange resin possessing tertiary amine or pyridine functional groups or a strongly basic anionic exchange resin possessing quaternary amine fuctional groups. The resins are in sulfate form and have a cross-linked acrylic or styrene resin matrix. Lactic acid is desorbed with water or dilute inorganic acid, e.g., sulfuric. The pH of the feed is maintained below the ionization constant (pKa) of lactic acid to obtain high selectivity.
    Type: Grant
    Filed: May 8, 1989
    Date of Patent: November 26, 1991
    Assignee: UOP
    Inventors: Santi Kulprathipanja, Anil R. Oroskar
  • Method for purification of 2,2'-di(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-naphthaldehyde)
    Patent number: 5059717
    Abstract: The method according to the present invention comprises purification of 2,2'-di-(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-naphthaldehyde) by crystallization from a solution thereof in diethyl ether with a concentration of 0.002-0.2 g/ml by adding 0.25-3 parts of hexane by volume (of diethyl ether) keeping the mixture at a temperature of from 10.degree. to 30.degree. C., separation of the resulting precipitate and drying thereof to give the desired product.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: October 22, 1991
    Inventors: Bakhtiyar T. Ibragimov, Samat A. Talipov, Rustam G. Mardanov, Takhir F. Aripov
  • Ortho-substituted 1-naphthyl ethers and fungicides containing these
    Patent number: 5057537
    Abstract: Ortho-substituted 1-napthyl ethers of the formula ##STR1## where X is CH or N, Y is saturated or unsaturated alkylene and R is aryl, aryloxy, arylthio or arylalkoxy, the aromatic ring being substituted or unsubstituted, and fungicides containing these compounds.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: October 15, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Wenderoth, Hubert Sauter, Albrecht Harreus, Franz Roehl, Eberhard Ammermann, Gisela Lorenz
  • Process for preparing N-substituted amino acid esters
    Patent number: 5055588
    Abstract: A process for preparing N-substituted amino acid esters having the formula (I): ##STR1## wherein R.sub.1 and R.sub.4, the same or different, are an alkyl, aralkyl, cycloalkyl or aryl group; and R.sub.2 and R.sub.3, the same or different,are an alkyl, aralkyl, aryl, heterocycle-alkyl, aminoalkyl or guanidylalkyl, by the reaction of .alpha.-amino acid esters with .alpha.-substituted carboxylic acid esters, under the condition of substantially free from solvent, which can afford their optical isomers in a good yield.
    Type: Grant
    Filed: May 9, 1990
    Date of Patent: October 8, 1991
    Assignee: Daicel Chemical Industries Ltd.
    Inventors: Ichirou Takase, Kazuo Sato, Noritsugu Yamasaki, Yukihisa Goto
  • Myo-inositol analogs and methods for their use
    Patent number: 5053399
    Abstract: The present invention relates to a method for inhibiting the phosphatidylinositol cycle in a cell by contacting the cell with certain myo-inositol analogs. Such myo-inositol analogs can also be utilized to treat phosphatidylinositol cycle-dependent conditions. The present invention also provides novel myo-inositol analogs.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: October 1, 1991
    Assignee: University of Pittsburgh
    Inventor: Alan P. Kozikowski
  • Process for producing .alpha.-hydroxyisobutyric acid
    Patent number: 5053535
    Abstract: A process for producing an .alpha.-hydroxyisobutyric acid which comprises hydrolyzing .alpha.-hydroxyisobutyric acid ester in the presence of an organic sulfonic acid catalyst, using an .alpha.-hydroxyisobutyric acid ester as the starting material.According to said process, .alpha.-hydroxyisobutyric acid can be efficiently produced.
    Type: Grant
    Filed: November 23, 1990
    Date of Patent: October 1, 1991
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Yoshikazu Shima, Takafumi Abe, Hirofumi Higuchi, Koichi Kida