Patents Examined by Bryan Kilpatrick
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Patent number: 11850593Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.Type: GrantFiled: June 12, 2020Date of Patent: December 26, 2023Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
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Patent number: 11786914Abstract: A magnetic separation filter has an unsupported magnetically soft material layer having a plurality of pores, and, optionally, a passivation layer disposed on the magnetically soft material layer. The magnetic separation filter may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.Type: GrantFiled: October 4, 2016Date of Patent: October 17, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: David Issadore, Venkata Yelleswarapu, Jina Ko
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Patent number: 11772969Abstract: The solar-powered oxygen production system for hospitals is useful for producing oxygen in hospital settings without the need for an external power source. The system includes one or more photovoltaic (PV) solar panels mounted on the roof of a hospital and an oxygen production system housed within the equipment room of the hospital. The solar panels provide the electrical power needed for the oxygen production system. The solar panels are mounted on the roof using solar panel supports. The number of panels and the power output of each panel can be selected depending on the electrical power requirements of the oxygen production system. The oxygen production system includes an LED for activating a black phosphorous catalyst in the atmospheric air to convert water vapor in the air into hydrogen and oxygen.Type: GrantFiled: April 28, 2022Date of Patent: October 3, 2023Assignee: KING FAISAL UNIVERSITYInventors: Aisha Al-Olayan, Hessa Al-Mousa, Marwah Al-Mutayib
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Patent number: 11662313Abstract: A microfluidic device includes a substrate having an electromagnetic wave transmission property, a lid member facing the substrate and being separated from the substrate such that a flow channel is formed between the substrate and the lid member, a light absorption layer which is placed in the flow channel and absorbs an electromagnetic wave, and a microwell array formed on the substrate and having plural microwells that are open to the flow channel to receive a target of analysis.Type: GrantFiled: June 26, 2018Date of Patent: May 30, 2023Assignee: TOPPAN PRINTING CO., LTD.Inventors: Yoichi Makino, Keisuke Goto
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Patent number: 11642676Abstract: A closure and a container assembly are disclosed. The closure includes a first visual identifier and a second visual identifier, wherein the second visual identifier is different from the first visual identifier. The first visual identifier may be a first color, and the second visual identifier may be a second color. At least one of the first and/or second visual identifier may include a fluorescent compound having a characteristic fluorescent spectra. The first visual identifier and the second visual identifier may be provided on the annular skirt of the closure. The fluorescent compound may be provided on at least one of the closure and the container assembly and can be used to facilitate automated visualization of the fluorescent compound under fluorescence excitation light.Type: GrantFiled: September 28, 2018Date of Patent: May 9, 2023Assignee: Becton, Dickinson and CompanyInventors: Ashley Palmer, Kurt Stoeckmann, Craig Owen Russ, Robert S. Ross, Girish Parmar, Craig A. Gelfand
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Patent number: 11635437Abstract: Disclosed herein is a method for verifying the primary structure of a protein through comparative analyses between ion clusters observed in mass spectra and a series of simulated ion clusters deduced from its putative chemical formula. The method comprises the steps of: preparing a protein sample for mass spectrometric analyses; collecting mass spectra of the protein sample; obtaining master ion cluster from a plurality of ion clusters in the mass spectra; producing a series of simulated ion clusters according to the chemical formula of the protein; finding the best fit for the master ion cluster among the series of simulated ion clusters; and verifying if said best-fit simulated ion cluster corresponds to the chemical formula of the protein.Type: GrantFiled: November 23, 2016Date of Patent: April 25, 2023Assignee: SUN JET BIOTECHNOLOGY INC.Inventors: Yeou Guang Tsay, Ya-Fen Chen
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Patent number: 11598014Abstract: An ion source and ion recycle module includes an electrolyte reservoir, an eluent recovery chamber, and an ion exchange connector. The electrolyte reservoir includes a chamber containing an aqueous electrolyte solution including an electrolyte having a chamber inlet and a chamber outlet, and a first electrode. The chamber inlet is fluidically connected to a source chamber of an electrolytic eluent generator and configured to receive depleted electrolyte solution from the source chamber of the electrolytic eluent generator. The chamber outlet is fluidically connected to the source chamber of the electrolytic eluent generator and configured to provide recycled electrolyte solution to the electrolytic eluent generator source chamber. The eluent recovery chamber including a second electrode and configured to receive an eluent solution including eluent counter ions from the eluent generator; and the ion exchange connector including an ion exchange membrane stack.Type: GrantFiled: October 2, 2020Date of Patent: March 7, 2023Assignee: Dionex CorporationInventor: Kannan Srinivasan
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Patent number: 11525813Abstract: A container assembly for use with a high-pressure liquid chromatography (HPLC) instrument is disclosed, in which the container assembly, when coupled to a source of pressurized gas, provides fluid medium to the HPLC instrument at positive pressure. The container assembly has an external exterior container shell, an internal fluid container for holding fluid medium, an interstitial volume between the external exterior container shell and the internal fluid container, a port for fluidly connecting the volume to a pressurized gas source, and a port for fluidly connecting the internal fluid container to the HPLC instrument. As a pressurized gas in the interstitial volume increases, fluid medium flows out of the port connected to the internal fluid bag and container assembly at a positive pressure. A system incorporating the container assembly, and method of use of the same, are also disclosed.Type: GrantFiled: January 31, 2018Date of Patent: December 13, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Nathan Wrench, William Mainwaring-Burton, Chris Butcher, Nick Harrison
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Patent number: 11513038Abstract: The application relates to a sample holder (110) and a system (100). The application also relates to a method for processing a biological sample (S) and use of the sample holder or of the system in an analytical method or a diagnostic method. The sample holder (110) comprises a tubular member (111) with a wall that is at least locally transparent and at least locally permeable for reagents, wherein the tubular member consists at least partially of a transparent material.Type: GrantFiled: June 29, 2015Date of Patent: November 29, 2022Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Reinhold Wimberger-Friedl, Jacobus Hermanus Maria Neijzen, Anja Van De Stolpe
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Patent number: 11504098Abstract: Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers at room temperature. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of sample collection.Type: GrantFiled: March 30, 2022Date of Patent: November 22, 2022Assignee: NEPHROSANT, INC.Inventors: Robert Zawada, Corinne Mark, Christopher Goulart
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Patent number: 11478789Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting blood cells in biological samples. A small unmeasured quantity of a biological sample such as whole blood is placed in the disposable test cartridge which is then inserted into the cell analyzer. The analyzer isolates a precise volume of the biological sample, mixes it with self-contained reagents and transfers the entire volume to an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping, when it is transferred into the imaging chamber. Images of essentially all of the cellular components within the imaging chamber are analyzed to obtain counts per unit volume.Type: GrantFiled: February 5, 2016Date of Patent: October 25, 2022Assignee: Medica CorporationInventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Donald Barry, Jr., Dirk Osterloh, Chen Yi, Tyler Cote
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Patent number: 11478799Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.Type: GrantFiled: March 20, 2018Date of Patent: October 25, 2022Assignee: The University of ChicagoInventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
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Patent number: 11434458Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.Type: GrantFiled: January 11, 2017Date of Patent: September 6, 2022Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Christopher David Hinojosa, Josiah Sliz, Daniel Levner, Guy Thompson, Hubert Geisler, Jose Fernandez-Alcon, Donald E. Ingber
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Patent number: 11426727Abstract: Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.Type: GrantFiled: April 26, 2021Date of Patent: August 30, 2022Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Peter Paulicka, Jeffrey Jasperse
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Patent number: 11413614Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.Type: GrantFiled: March 31, 2016Date of Patent: August 16, 2022Assignee: The University of ChicagoInventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
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Patent number: 11413615Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.Type: GrantFiled: March 20, 2018Date of Patent: August 16, 2022Assignee: The University of ChicagoInventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
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Patent number: 11366051Abstract: A device including a microfluidic channel structure formed on a substrate and including a first channel and a fluid actuator within the microfluidic channel structure. A sense region within the first channel is to receive a fluid flow of target biologic particles for counting in a single file pattern, with the sense region having a volume on a same order of magnitude as a volume of a single one of the target biologic particles.Type: GrantFiled: January 30, 2015Date of Patent: June 21, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Jeremy Sells, Nick McGuinness, Chantelle Domingue, Manish Giri
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Patent number: 11278898Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.Type: GrantFiled: March 20, 2018Date of Patent: March 22, 2022Assignee: The University of ChicagoInventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
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Patent number: 11266988Abstract: The invention, is directed to devices and methods for low cost and convenient separation, of plasma from whole blood. In some embodiments, devices of the invention comprise an integrated collection of channels and chambers m a body that permit acquisition of a blood sample by capillary action, centrifugal separation of cells from plasma, and manual dispensing of purified plasma by simple pinching of a bellows chamber to force air into plasma-holding channels which thereby expels a predetermined volume of the purified plasma.Type: GrantFiled: March 14, 2018Date of Patent: March 8, 2022Inventors: Hrair Kirakossian, Ming Tan
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Patent number: 11268962Abstract: A sample is dissolved in a reagent 4 containing an organic solvent in a conversion vessel 11. A gas is supplied from a first gas supply part into the conversion vessel 11 via a reagent introduction tube 17, and thus the interior of the conversion vessel 11 is pressurized. A gas is supplied from a second gas supply part into the reagent 4 in the conversion vessel 11 via a reagent discharge tube 18, and thus gas bubbles 41 are formed in the reagent 4.Type: GrantFiled: February 20, 2015Date of Patent: March 8, 2022Assignee: SHIMADZU CORPORATIONInventors: Tomoko Yamaguchi, Natsuki Iwata