Abstract: Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.
Type:
Grant
Filed:
September 29, 2000
Date of Patent:
March 23, 2004
Assignee:
UAF Technologies and Research, LLC
Inventors:
James Berger Camden, Joseph K. Agyin, James C. Quada, Jr.
Abstract: An antilipemic composition, particularly to achieve a lowering of cholesterol levels comprises a biocompatible anionic polysaccharide material containing non-sulphated glucuronic acid.
Type:
Grant
Filed:
January 19, 2001
Date of Patent:
March 16, 2004
Assignee:
Alpenstock Holdings Limited
Inventors:
Ivan Santar, Frantisek Kiss, Jiri Briestensky
Abstract: The present invention provides novel complexes consisting of certain GLP-1 molecules associated with a divalent metal cation that is capable of co-precipitating with a GLP-1 molecule. Pharmaceutical compositions and methods of using such complexes for enhancing the expression of insulin in B-type islet cells is claimed, as is a method for treating maturity onset diabetes mellitus in mammals, particularly humans.
Abstract: A cosmetic skin/hair darkening composition for topical application to skin and/or hair is provided that comprises for 0.1 to 10% by weight of a peptide having an isoelectric point ranging from 6 to 11.
Type:
Grant
Filed:
November 13, 1998
Date of Patent:
February 24, 2004
Assignee:
Chesebrough-Pond's USA Co., division of Conopco, Inc.
Abstract: This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of Formula I and II:
Type:
Grant
Filed:
July 11, 2001
Date of Patent:
February 24, 2004
Assignee:
Warner-Lambert Company
Inventors:
Alexander James Bridges, David Thomas Dudley, James Leslie Mobley, Alan Robert Saltiel
Abstract: An apparatus for preventing particulate matter and residue build-up within a vacuum exhaust line of a semiconductor processing device. The apparatus uses RF energy to form excite the constituents of particulate matter exhausted from a semiconductor processing chamber into a plasma state such that the constituents react to form gaseous products that may be pumped through the vacuum line. The apparatus may include a collection chamber structured and arranged to collect particulate matter flowing through the apparatus and inhibiting egress of the particulate matter from the apparatus. The apparatus may further include an electrostatic collector to enhance particle collection in the collection chamber and to further inhibit egress of the particulate matter.
Type:
Grant
Filed:
June 30, 2000
Date of Patent:
February 10, 2004
Assignee:
Applied Materials Inc.
Inventors:
Ben Pang, David Cheung, William N. Taylor, Jr., Sebastion Raoux, Mark Fodor
Abstract: An apparatus for preventing particulate matter and residue build-up within a vacuum exhaust line of a semiconductor processing device. The apparatus uses RF energy to excite the constituents of particulate matter exhausted from a semiconductor processing chamber into a plasma state such that the constituents react to form gaseous products that may be pumped through the vacuum line. The apparatus may include a collection chamber structured and arranged to collect particulate matter flowing through the apparatus and inhibiting egress of the particulate matter from the apparatus. The apparatus may further include an electrostatic collector to enhance particle collection in the collection chamber and to further inhibit egress of the particulate matter.
Type:
Grant
Filed:
December 4, 2000
Date of Patent:
January 20, 2004
Assignee:
Applied Materials Inc.
Inventors:
Ben Pang, David Cheung, William N. Taylor, Jr., Sebastien Raoux, Mark Fodor
Abstract: Light emitting compounds of the formula
where R1 is a light-emitting moiety, R2 is a CRF-related peptide and fragment, derivative or analog thereof and L is a linker moiety, which may be present or absent. The peptide is linked at a first amino acid position to (C—X) which, in turn, is selected from the group including C═O, C═S, CH(OH), C═C═O, C═NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties. Optionally the compound may include a linker moiety between the peptide and the C—X binding group. Preferably, the compound exhibits substantial biological activity in the presence of receptors having affinities for CRF-related peptides.
Type:
Grant
Filed:
July 19, 1999
Date of Patent:
January 20, 2004
Assignee:
Advanced Bioconcept Company
Inventors:
Clarissa Desjardins, Jacek Slon-Usakiewicz, Katherine J. Bonter
Abstract: Light emitting compounds of the formula:
where R1 is a light-emitting moiety and R2 is a motilin peptide and fragment, derivative or analog thereof The peptide is linked at a first amino acid position to (C—X) which, in turn, is selected from the group including C═O, C═S, CH(OH), C═C═O, C═NH, CH2, CH(OR), CH(NR), CH(R), CR3R4, and C(OR3)OR4 where R, R3, and R4 are alkyl moieties or substituted alkyl moieties. Optionally the compound may include a linker moiety between the peptide and the C—X binding group. Preferably, the compound exhibits substantial biological activity in the presence of receptors having affinities for motilin peptides.
Type:
Grant
Filed:
March 31, 2000
Date of Patent:
January 13, 2004
Assignee:
Advanced Bioconcept Company
Inventors:
Clarissa Desjardins, Jacek Slon-Usakiewicz, Katherine J. Bonter
Abstract: Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.
Abstract: The invention provides a therapeutic aqueous composition comprising: (i) a therapeutically effective amount of a hexahydro-5-pyrimidinamine compound, e.g. hexetidine; (ii) a salification acidic compound; and (iii) a polyalkoxylated fatty alcohol. The composition shows enhanced stability.
Abstract: The invention relates to pharmaceutical compositions against peptic ulcer as well as to a method of treating peptic ulcer. The compositions contain and the method of treatment employs zinc hyaluronate as an active ingredient having a molecular weight in the range of 500,000 to 1,200,000 daltons.
Type:
Grant
Filed:
September 21, 2000
Date of Patent:
December 2, 2003
Assignee:
Richter Gedeon Vegyeszeti Gyar RT.
Inventors:
Janos Illes, Judit Matuz, Erzsabet Neszmelyi, Gaborne Forrai, Bela Stefko, Katalin Saghy, Laszlo Szporny
Abstract: The present invention relates to the use of a combination of an antiotensin-converting enzyme inhibitor (CEI) and of a diuretic for the treatment of arteriolo-capillary microcirculatory disorders and to pharmaceutical compositions containing the same.
Type:
Grant
Filed:
May 18, 2000
Date of Patent:
November 25, 2003
Assignee:
Les Laboratoires Servier
Inventors:
David Guez, Pierre Schiavi, Bernard Levy
Abstract: This invention is a safe and effective composition and method for treating acute migraine attacks using pseudoephedrine, acetaminophen, and other agents in an orally administrated form to alleviate the pain and cluster of symptoms characteristic of migraine attacks such as nausea, photophobia, phonophobia, and functional disabilities as well as the prodrome phase of a migraine attack.
Abstract: The present invention relates to a composition useful for qualitative screening of phosphate solubilizing microorganism, and also relates to a synergistic composition for qualitative screening of phosphate solubilizing microorganisms, based upon visual observation.
Type:
Grant
Filed:
March 6, 2001
Date of Patent:
October 28, 2003
Assignee:
Council of Scientific & Industrial Research
Abstract: This invention provides a method of rapidly and reliably delivering codeine, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment of pain or cough. The present invention further provides pharmaceutical compositions comprising codeine, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without other analgesic and/or antitussive compounds.
Type:
Grant
Filed:
October 1, 1999
Date of Patent:
August 19, 2003
Assignee:
New Millennium Pharmaceutical Research, Inc.
Inventors:
Anwar A. Hussain, Lewis W. Dittert, Abeer M. Al-Ghananeem
Abstract: Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration, or survival of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.
Abstract: The invention is directed to methods and compositions that can be used in the treatment of headaches. In particular, methods and compositions are described involving the combination of a long-acting NSAID and a 5-HT agonist. Included among the long-acting NSAIDs are cyclo-oxygenase-2 inhibitors.