Patents Examined by C. Styles
-
Patent number: 6710073Abstract: Peripherally administered analogs and derivatives of Brefeldin A are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal tissues.Type: GrantFiled: December 2, 1996Date of Patent: March 23, 2004Assignee: The Regents of the University of CaliforniaInventors: Katumi Sumikawa, Ken-Ichi Ito, James L. McGaugh
-
Patent number: 6693190Abstract: Metal chelates capable of exhibiting an immobilized relativity between about 60 and 200 mM−1s−1/metal atom are useful as magnetic resonance imaging agents. Additionally, a compound which is useful as a metal-chelating ligand has the following formula: wherein Q is a 4- to an 8-membered carbocyclic ring which may be fully or partially saturated; t is an integer from 2 to 16; each R group is independently hydrogen, —OH, —CH2—A, —OCH2CH(OH)CH2—A or a functional group capable of forming a conjugate with a biomolecule, provided that at least two of the R groups are selected from —CH2—A or —OCH2CH(OH)CH2—A; and A is a moiety capable of chelating a metal atom.Type: GrantFiled: May 11, 1994Date of Patent: February 17, 2004Assignee: Bracco International B.V.Inventors: Ramachandran S. Ranganathan, Radhakrishna Pillai, Peter C. Ratsep, Rajesh Shukla, Michael F. Tweedle, Xun Zhang
-
Patent number: 6653296Abstract: Resolved enantiomers of the formula (IA) and (IB) wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.Type: GrantFiled: February 2, 1995Date of Patent: November 25, 2003Assignees: Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.Inventors: Antonin Holy, Hana Dvorakova, Erik Desire Alice De Clercq, Jan Marie Rene Balzarini
-
Patent number: 6586593Abstract: A process for the manufacture of 3,5-diamino-6-substituted-1,2,4-triazines is disclosed which comprises the steps of: (a) reacting a compound of formula (II): with aminoguanidine salts, (b) dehydrating the compound obtained to form a compound of formula IV, and (c) cyclization of the compound of formula IV into a 3,5-diamino-6-substituted-1,2,4-triazine compound of formula I or into a hydrated form thereof.Type: GrantFiled: January 16, 2002Date of Patent: July 1, 2003Assignee: Brantford Chemicals Inc.Inventors: Bhaskar Reddy Guntoori, Daqing Che, K. S. Keshava Murthy
-
Patent number: 6573379Abstract: The present invention relates to a method for preparing 5- and 6-halomethyl quinoxalines. The method comprises contacting a 5- or 6-methyl quinoxaline with a halogenating agent in the presence of a radical initiator in a solvent selected from the group consisting of fluorobenzene, difluorobenzenes, trifluorobenzenes, chlorobenzene, dichlorobenzenes, trichlorobenzenes, &agr;, &agr;, &agr;-trifluorotoluene and &agr;, &agr;, &agr;-trichlorotoluene. The invention also relates to preparing 6-bromomethyl quinoxaline with N-bromosuccinimide in the presence of a radical initiator in 1,2-dichloroethane. The method for halogenating benzylic methyl groups may also be employed to halogenate a wide variety of halomethyl heterocyclic compounds.Type: GrantFiled: September 19, 2002Date of Patent: June 3, 2003Assignee: Air Products and Chemicals, Inc.Inventor: Juan Jesus Burdeniuc
-
Patent number: 6545037Abstract: A compound of formula (I): which is useful as a TXA2 and 5-HT2 receptor and pharmaceutical compositions containing the same.Type: GrantFiled: March 14, 2002Date of Patent: April 8, 2003Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Jean-Jacques Descombes
-
Patent number: 6514976Abstract: Described herein is a compound of the formula wherein Ar′ is a mono or bicyclic aromatic or heteroaromatic radical substituted with one to three substituents selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; R1 is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio; R2 is phenyl, naphthyl or (C3-C12)cycloalkyl substituted with one or two substituents selected from the group consisting of hydrogen (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; X is —(C═O)—; or a pharmaceutically acceptable salt racemate, optical isomer or solvatType: GrantFiled: April 30, 2002Date of Patent: February 4, 2003Assignee: Eli Lilly and CompanyInventors: Daniel Timothy Kohlman, Yao-Chang Xu
-
Patent number: 6414144Abstract: The present invention provides processes for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b][1, 4]diazepino[6, 7, 1-hi]indole derivatives of the general formula: wherein: R is H, alkyl, acyl, or aroyl; R1, R2, R4 and R5 are H, OH, alkyl, cycloalkyl, alkoxy s, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino s, dialkylamino, fluorinated alkoxy, acyl, aryl, or aroyl; R3 is H, alkyl, cycloalkyl, alkoxy, fluorinated alkyl, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, aryl, or aroyl; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of central nervous system disorders.Type: GrantFiled: November 2, 2001Date of Patent: July 2, 2002Assignee: WyethInventors: Gregory Scott Welmaker, Joan Eileen Sabalski
-
Patent number: D439299Type: GrantFiled: June 6, 2000Date of Patent: March 20, 2001Inventor: Herman Chiang
-
Patent number: D498009Type: GrantFiled: November 14, 2003Date of Patent: November 2, 2004Assignee: Everbrite, Inc.Inventors: Beth A. Donnelly, Chad Boyles
-
Patent number: D499443Type: GrantFiled: August 28, 2003Date of Patent: December 7, 2004Assignee: Yamaha CorporationInventor: Masaharu Ohno
-
Patent number: D499755Type: GrantFiled: August 28, 2003Date of Patent: December 14, 2004Assignee: Yamaha CorporationInventor: Masaharu Ohno
-
Patent number: D414374Type: GrantFiled: April 16, 1997Date of Patent: September 28, 1999Assignee: Atico International USA, Inc.Inventor: Lap-Yan Ting
-
Patent number: D415821Type: GrantFiled: December 17, 1998Date of Patent: October 26, 1999Assignee: Moen IncorporatedInventors: Eduardo Milrud, Thomas H. Burchard, Stephanie Schwarz, Gert Trauernicht, Jonas Brickus
-
Patent number: D419141Type: GrantFiled: July 22, 1998Date of Patent: January 18, 2000Assignee: Silicon Graphics, Inc.Inventors: Daniel E. Evanicky, Tina Zimmermann, Bob Brunner