Patents Examined by Carolyn L. Smith
-
Patent number: 8296116Abstract: The invention develops models of functional proteomics. Simulation scenarios of protein pathway vectors and protein-protein interactions are modeled from limited information in protein databases. The system focuses on three integrated subsystems, including (1) a system to model protein-protein interactions using an evolvable Global Proteomic Model (GPM) of functional proteomics to ascertain healthy pathway operations, (2) a system to identify haplotypes customized for specific pathology using dysfunctional protein pathway simulations of the function of combinations of single nucleotide polymorphisms (SNPs) so as to ascertain pathology mutation sources and (3) a pharmacoproteomic modeling system to develop, test and refine proposed drug solutions based on the molecular structure and topology of mutant protein(s) in order to manage individual pathologies. The system focuses on simulating the degenerative genetic disease categories of cancer, neurodegenerative diseases, immunodegenerative diseases and aging.Type: GrantFiled: January 30, 2008Date of Patent: October 23, 2012Inventor: Neal Solomon
-
Patent number: 8296300Abstract: The present invention relates to a method for reconstructing protein database for identifying a protein and a method for screening a protein using the same, more precisely a method for reconstructing protein database, and a method for identifying a protein using the same. The method for reconstructing protein database and the method for identifying the protein of the invention are very useful for the investigation of endogenous proteins and their functions and interactions, and are further effectively used for the development of diagnostic and therapeutic agents for various diseases.Type: GrantFiled: August 18, 2006Date of Patent: October 23, 2012Assignee: Korea Basic Science InstituteInventors: Kyung-Hoon Kwon, Jong Shin Yoo
-
Patent number: 8249814Abstract: Disclosed is a method of testing for colorectal cancer in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has colorectal cancer. Also disclosed are kits for measuring data corresponding to the products of selected biomarkers, and kits and methods of monitoring therapeutic efficacy of treatments for colorectal cancer.Type: GrantFiled: October 23, 2006Date of Patent: August 21, 2012Assignee: GeneNews Inc.Inventors: Choong-Chin Liew, Mark Han, Thomas Yager, Samuel Chao, Run Zheng, Hongwei Zhang
-
Patent number: 8239136Abstract: In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.Type: GrantFiled: October 23, 2006Date of Patent: August 7, 2012Assignee: GeneNews Inc.Inventors: Choong-Chin Liew, Mark Han, Thomas Yager, Samuel Chao, Run Zheng, Hongwei Zhang
-
Patent number: 8224584Abstract: System for quantifying analyte polynucleotides employs computer-implemented analysis of real-time amplification data using a calibration curve defined by parametric equations.Type: GrantFiled: October 27, 2010Date of Patent: July 17, 2012Assignee: Gen-Probe IncorporatedInventors: James M. Carrick, Mark R. Kennedy, Jeffrey D. Chismar
-
Patent number: 8140303Abstract: [Problem] There is provided a bioequivalence evaluation method not only of evaluating bioequivalence between an original drug and a corresponding generic drug but also of enabling to compare bioequivalence between generic drugs. [Means of Solving the Problem] The bioequivalence between generic drugs is evaluated according to the Expression (1) wherein CCVCmax g stands for the calibration coefficient of variation of Cmax (the maximum blood concentration), CCVTmax g stands for the calibration coefficient of variation of Tmax (the time to maximum blood concentration), CCVT1/2 g stands for the calibration coefficient of variation of the half-life (T1/2), and CCVAUC g stands for the calibration coefficient of variation of AUC (the blood concentration-area under the curve).Type: GrantFiled: December 24, 2008Date of Patent: March 20, 2012Inventor: Masato Terashita
-
Patent number: 8131476Abstract: A system and methods for co-registering multi-channel images of a tissue micro array, comprising the steps of, providing a biological material on a substrate; applying one or more molecular probes, adapted to provide fluorescent molecular markers, to the biological material; obtaining a first digital image of the biological material and the fluorescent molecular markers; applying a morphological stain to the biological material; obtaining a second digital image of the biological material, computing information common to the first and second images; and co-registering the second image with the first image based on one or more registration metrics.Type: GrantFiled: August 7, 2006Date of Patent: March 6, 2012Assignee: General Electric CompanyInventors: Harvey Ellis Cline, Ali Can
-
Patent number: 8131474Abstract: The invention relates to a method for investigating the glucose metabolism of a human being for disease-relevant and/or disease-related particularities. The glucose concentration g(t1) to g(tn) of a body fluid is measured at time points t1 to tn that are distributed over a period of at least six hours. The data points are then determined in phase space coordinates from the glucose concentration measuring values g(t1) to g(tn). The data points are then processed to highlight disease-relevant and/or disease-related particularities of the glucose metabolism of the investigated human being. The processing of the data points can be implemented by plotting them in a phase space representation or by determining from the data points a disturbance parameter that is correlated to the severity of a disturbance of glucose metabolism.Type: GrantFiled: March 15, 2006Date of Patent: March 6, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Arnulf Staib, Johannes Pill, Reinhard Kotulla, Reiner Hegger
-
Patent number: 8110353Abstract: A catalytic system and method of catalyzing reactions that uses a novel toehold exchange mechanism that allows a specified input to catalyze the release of a specified output, which in turn can serve as a catalyst for other reactions is provided. This toehold exchange catalyst system, which can be driven forward by the configurational entropy of the released molecule, provides an amplifying circuit element that is simple, fast, modular, composable, and robust. Using this toehold exchange catalyst system it has been possible to construct and characterize several circuits that amplify nucleic acid signals, including a feed-forward cascade with quadratic kinetics and a positive feedback circuit with exponential growth kinetics.Type: GrantFiled: February 4, 2008Date of Patent: February 7, 2012Assignee: California Institute of TechnologyInventors: David Zhang, Andrew J. Turberfield, Erik Winfree
-
Patent number: 8090562Abstract: Measurement of circulating ST2 and natriuretic peptide (e.g., NT-proBNP) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure.Type: GrantFiled: April 17, 2009Date of Patent: January 3, 2012Assignee: Critical Care Diagnostics, Inc.Inventors: James V. Snider, Eugene R. Heyman
-
Patent number: 8086432Abstract: A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin). The actin and myosin interact with one another in the presence of ATP to rotate the cylinders or cones relative to one another, and this rotational energy is harnessed to produce work. The concentration of ATP and the number of nested cylinders or cones can be used to control the rotational speed of the motor. The length of the cylinders can also be used to control the power generated by the motor. In another embodiment, the molecular motor includes at least two annular substrates wherein one annular substrate is coated with a first motor protein and the other annular substrate is coated with a second motor protein. The first and second motor proteins interact with each other to move the second annular relative to the first annular substrate.Type: GrantFiled: January 24, 2008Date of Patent: December 27, 2011Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Thomas D. Schneider, Ilya Gennadiyevich Lyakhov
-
Patent number: 8078407Abstract: The present invention describes a system and method of using individuals' behavioral and physiologic information to identify disease-influencing genes.Type: GrantFiled: February 2, 2000Date of Patent: December 13, 2011Assignee: Health Hero Network, Inc.Inventor: Stephen J. Brown
-
Patent number: 8068987Abstract: The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.Type: GrantFiled: August 13, 2002Date of Patent: November 29, 2011Assignee: BG Medicine, Inc.Inventors: Noubar B. Afeyan, Jan van der Greef, Frederick E. Regnier, Aram S. Adourian, Eric K. Neumann, Matej Oresic, Elwin Robbert Verheij
-
Patent number: 8065091Abstract: Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.Type: GrantFiled: October 30, 2007Date of Patent: November 22, 2011Assignee: International Business Machines CorporationInventors: Isidore Rigoutsos, Tien Huynh, Aristotelis Tsirigos, Alice Carolyn McHardy, Kevin Charles Miranda
-
Patent number: 8060348Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.Type: GrantFiled: November 30, 2006Date of Patent: November 15, 2011Assignee: General Electric CompanyInventors: Harvey Ellis Cline, Ali Can, Xiaodong Tao, Robert John Filkins, Maximilian Lewis Seel, Michael Christopher Montalto
-
Patent number: 8046198Abstract: The present invention discloses a novel method for identifying an individual who may be susceptible to develop a developmental disorder. In one particular example, an individual is identified who is genetically susceptible to becoming schizophrenic. In addition, the present invention discloses a novel method for identifying individuals who are genetically susceptible to have offspring with a developmental disorder. Methods of diagnosing, preventing and treating developmental disorders such as schizophrenia are also provided.Type: GrantFiled: June 23, 2005Date of Patent: October 25, 2011Assignee: University of Medicine and Dentistry of New JerseyInventors: William G. Johnson, Edward Scott Stenroos
-
Patent number: 8036861Abstract: The present invention relates to methods and means for determining the replication rate of a viral population. More specifically, the invention provides methods and means for determining the replication rate of a viral population by performing a linear regression on signal data generated by cells infected with dilutions of the viral population. The methods are useful for monitoring the progression of diseases associated with viruses, identifying effective drug regimens for the treatment of viral infections, and identifying and determining the biological effectiveness of potential therapeutic compounds.Type: GrantFiled: October 13, 2006Date of Patent: October 11, 2011Assignee: Tibotec PharmaceuticalsInventors: Laurence Tatiana Rimsky, Herwig Gaston Emiel Van Marck, Marie-Pierre T. M. M. G. De Bethune, Lee Terry Bacheler
-
Patent number: 8036868Abstract: A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or “virtual image.” In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of “optical objectives” and “virtual objectives.” Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.Type: GrantFiled: September 11, 2009Date of Patent: October 11, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Jack A. Zeineh, Usman Rashid, Rui-Tao Dong
-
Patent number: 8032310Abstract: A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search.Type: GrantFiled: July 2, 2005Date of Patent: October 4, 2011Assignee: The United States of America as represented by the Secretary of the NavyInventors: David A Stenger, Jennifer Thornton
-
Patent number: 8027814Abstract: The present invention provides methods for assessing a condition in an individual by analyzing a cerebrospinal fluid sample from the individual, for example, by spectroscopy. Further, the invention provides methods for determining an amount of blood in the cerebrospinal fluid sample; methods for determining concentrations of analytes in the cerebrospinal fluid sample; methods for determining a length of time the blood has been in the cerebrospinal fluid sample; and methods for rapidly obtaining a differential diagnosis between conditions indicated by blood in the cerebral spinal fluid. Moreover, the present invention provides instruments capable of rapidly assessing a condition in and individual by point-of-care analysis of a cerebral fluid sample from an individual.Type: GrantFiled: August 1, 2005Date of Patent: September 27, 2011Assignee: University of CincinnatiInventors: Fred R. Beyette, Jr., Joseph F. Clark, Chad J. Morgan, James J. Caffery, Jr., Prashant Bhadri, Gail Pyne-Geithman, Anindya Majumder