Abstract: Organic chemical compounds based upon the naphthyridine molecule are disclosed which have potent gastric secretion inhibitory properties. The naphthyridinone is substituted with a substituted amino alkyl group at the 1-position, and variously substituted at the remaining positions. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.

Abstract: Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.

Abstract: In the treatment of skin wherein an aqueous paste is applied to the skin, left in contact therewith for a period of time and thereafter removed, the improvement which comprises placing over the paste a foil containing at least about 3 percent of water soluble collagen by weight and having a water permeability of more than about 0.1 gram/dm.sup.2 /minute, whereby collagen is transported through the paste and is absorbed by the skin. Desirably the foil is about 0.01 to 0.03 mm thick and is cross-linked to an extent corresponding to that produced by about 0.1-0.5 percent by weight of glutardialdehyde applied in an acid medium. It may further contain a cosmetically active agent such as an amino acid, peptide, protein, hormone, placenta-extract, phosphatide, tissue-extract, fresh cells and vitamins. The paste may be dried by heating, producing shrinkage of the foil to increase contact with the skin.

Abstract: New dicarboxylic acid derivatives containing a N,N-heterocyclic radical are obtained by reacting 1 mol of a cyclic ureide, such as 1,1-methylene-bis-hydantoin, benzimidazolone, parabanic acid, 6-methyluracil or 2,2-diethylbarbituric acid, with 2 mols of 4-halogenomethylbenzoic acid derivatives. The new dicarboxylic acid derivatives are valuable monomers for the manufacture of stable plastics. Thus, the dicarboxylic acid dialkyl esters, for example, can be converted by means of diols into polyesters with valuable mechanical properties.

Abstract: A process for producing amorphous preparations of steryl glucoside monopalmitates, wherein steryl glucoside monopalmitates are heated at a temperature above 110.degree. C up to about 145.degree. C or the compounds are dissolved in an organic solvent in which they are soluble with a solvent which is then distilled off, and the compounds then pulverized and mixed with physiologically harmless organic or inorganic fine particles in a proportion of 0.5 times (by weight) of the compounds or more, thereby homogeneously dispersing the amorphous compounds in the fine particles or uniformtly adsorbing the compounds on the fine particles, and the resulting preparations which have hemostatic properties and are readily absorbable upon ingestion. The starting steryl glucoside monopalmitates are obtained in crystalline form as from soy beans or other vegetable sources.

Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.3 is hydrogen or halo having an atomic weight of about 19 to 36, which are useful as minor tranquilizers, sleep inducers, muscle relaxants, neuroleptics and anti-ulcer agents.

Abstract: The present invention relates to an agent for intravascular administration, said agent consisting of a suspension of minute polysaccharide particles having a size such that subsequent to being administered intravascularly, they block the finer blood vessels of the body and a diagnostic agent.

Abstract: Oral compositions for plaque and caries inhibition contain a salt of an oxo-acid (formerly called oxy-acid) of phosphorus or a mixed salt of an oxo-acid of phosphorus and hydrofluoric acid with an orgaic base.

Abstract: There is provided, a novel 2-acetoxybenzoic acid-nicotinamide complex, which exhibits enhanced water solubility and dissolution characteristics, thus permitting rapid absorption of the 2-acetoxybenzoic acid through the gastrointestinal lining for attainment of exceptional 2-acetoxybenzoic acid blood levels.

Abstract: Schiff base derivatives of 3-amino-2-hydrazinopyridine are useful as antihypertensive agents.

Abstract: 5-Amino-2-hydrazinopyridine and derivatives thereof are useful as antihypertensive agents.

Abstract: 1-Hydrocarbon-3,3-diphenyl-4-hydroxymethyl-2-pyrrolidinones and methods for making them from 4,5-dihydro-3,3-diphenyl-4-hydrocarbylaminomethylfuran-2(3H)ones are disclosed. Methods for making the 4,5-dihydro-3,3-diphenyl-4-hydrocarbylaminomethylfuran-2(3H)ones are also disclosed. The novel compounds are useful intermediates for the preparation of pharmacologically active 4-(4,4-disubstitutedpiperidinylmethyl)-3,3-diphenyl-2-pyrrolidinones.

Abstract: Carbamic acid lactones of the formula ##STR1## wherein Y is H or alkyl of 1-4 carbon atoms and R.sub.2 and R.sub.

Abstract: A process for promoting the spherical crystallization of picloram, wherein an anionic polymeric acrylamide flocculating agent, when combined with a solution of picloram in an aqueous sulfuric acid medium, serves to promote the formation of polycrystalline picloram spheres and to greatly reduce the formation of fines.

Abstract: An antibacterial oral composition effective to promote oral hygiene containing an antibacterial antiplaque agent and an additive which reduces straining of dental surfaces without substantially diminishing the antibacterial and antiplaque activity of the agent. Bis-biguanido hexanes, such as chlorhexidine and alexidine, and quaternary ammonium salts, such as benzethonium chloride and cetyl pyridinium chloride, are typical examples of antibacterial agents. The antistain additive is a phosphono polycarboxylic acid compound, such as 1-phosphonoethane-1,2-dicarboxylic acid and salts thereof.

Abstract: An antibacterial oral composition effective to promote oral hygiene containing an antibacterial antiplaque agent and an additive which reduces staining of dental surfaces without substantially diminishing the antibacterial and antiplaque activity of the agent. Bis-biguanido hexanes, such as chlorhexidine and alexidine, and quaternary ammonium salts, such as benzethonium chloride and cetyl pyridinium chloride, are typical examples of antibacterial agents. The antistain additive is a diphosphono pyrrolidone compound, such as pyrrolidone-5,5-diphosphonic acid, or salts thereof.

Abstract: An antibacterial oral composition effective to promote oral hygiene containing an antibacterial antiplaque agent and an additive which reduces staining of dental surfaces without substantially diminishing the antibacterial and antiplaque activity of the agent. Bis-biguanido hexanes, such as chlorhexidine and alexidine, and quaternary ammonium salts, such as benzethonium chloride and cetyl pyridinium chloride, are typical examples of antibacterial agents. The antistain additive is an N-methylene phosphonate compound, such as iminodiacetic N-methylene phosphonic acid and salts thereof.

Abstract: A medical article is made non-thrombogenic by means of a surface coating containing heparin. The heparinized surface is stabilized by being contacted first with a cationic surfactant of the primary amine type and, subsequently, with a dialdehyde.

Abstract: An antibacterial oral composition effective to promote oral hygiene containing an antibacterial antiplaque agent and an additive which reduces staining of dental surfaces without substantially diminishing the antibacterial and antiplaque activity of the agent. Bis-biguanido hexanes, such as chlorhexidine and alexidine, and quaternary ammonium salts, such as benzethonium chloride and cetyl pyridinium chloride, are typical examples of antibacterial agents. The antistain additive is phosphonoacetic acid or salts thereof.

Abstract: A process to produce diazepine-3-carboxylates of the formula ##STR1## is selected from the group consisting of ##STR2## R.sub.6 is selected from the group consisting of hydrogen, halogen, nitro, cyano, trifluoromethyl, lower alkyl, and lower alkanoyl;R.sub.4 is lower alkyl; R.sub.3 is selected from the group consisting of phenyl, mono-substituted phenyl, disubstituted phenyl, pyridyl and mono-substituted pyridyl; and R.sub.2 is hydrogen or lower alkyl which comprises reacting a compound of the formula ##STR3## wherein R.sub.1 is of the formula ##STR4## AND R.sub.5 is lower alkyl with a compound of the formulaN.dbd.C-CH.sub.2 --COOR.sub.4in the presence of a base sufficiently strong to generate the anion of the isocyanoacetate.