Abstract: The present invention provides a skin attachment device for use with implantable medical devices which extend through the skin for prolonged durations.

Abstract: In certain aspects, the present disclosure is directed to a method of improving a patient's recovery after a neuro-ischemic event. The method can include identifying a patient who has suffered a neuro-ischemic event, and stimulating, for a period of time, a parasympathetic structure in the patient's cranium before, during, and/or after the patient undergoes a task-oriented therapy to improve the patient's recovery.

Abstract: A system for assessing risk associated with a suspected heart rhythm disorder includes at least one sensor for generating a signal received from a beating human heart over a plurality of time segments, and an analytic engine that receives the signal and calculates a change in the signal among at least a first time segment and a second time segment in response to a change in at least one of rate and regularity induced in the beating human heart. The analytic engine generates a risk score for the heart rhythm disorder based at least in part on the change in the signal. The system may further be configured to control modification of tissue of the beating human heart based on the risk score.

Abstract: A wearable system and methods for measuring physiological data from a device worn about a body part of a user is provided comprising a base module, a first sensor module, and a second sensor module. The base module comprises a display and a base computing unit. The first sensor module measures a gravitational force experienced by the device. The second sensor module is spatially positioned relative to the base module and over a portion of the body part for measuring one or more physiological characteristics calibrated based on the gravitational force measured with the first sensor module. The base module is adjustably positioned by the user relative to the second sensor module such that the sensor module maintains its positioning over the body part for sufficient contact with the body part for accurate measurements of physiological data regardless of the anthropometric size of the body part.

Abstract: A medical therapy system including liquid detection is disclosed. A medical therapy includes a case with an interior and an exterior. Within the interior of the case is the liquid detection system that includes a first electrode set with a first positive electrode and a first negative electrode. The liquid detection system further includes an impedance measurement circuit coupled to the first electrode set to determine impedance values between the first positive electrode and the first negative electrode. A threshold detector compares impedance values between the first electrode set to a first threshold impedance. A microprocessor is programmed to initiate an alarm when measured impedance from the first electrode set is below the first threshold impedance.

Abstract: Implantable medical devices, implantable medical device systems that include such implantable medical devices, and implantable medical device batteries, as well as methods of making. Such devices can include a battery of relatively small volume but of relatively high power (reported as therapeutic power) and relatively high capacity (reported as capacity density).

Abstract: There is provided a biosensor capable of improving the S/N ratio of a final photoplethysmographic signal regardless of the change in a noise component such as extraneous light. A biosensor includes a driving signal generation unit for generating a pulsed driving signal, a light-emitting element for emitting light in response to a generated driving signal, a light-receiving section including a light-receiving element for outputting a detection signal in accordance with the intensity of light received and an amplification unit for amplifying a detection signal output from the light-receiving element, a filter unit for removing a pulse wave component from a detection signal output from the light-receiving section to obtain a baseline signal, and a differential amplification unit for taking a difference between a detection signal output from the light-receiving section and a baseline signal obtained by the filter unit.

Abstract: A system and method for reducing inflammation of tissue of animal or human, which comprises an energy wave generator has an energy wave's frequency control mode. The energy wave's frequency control mode includes multiple controls for acting the energy wave generator to generate and emit energy waves each with a corresponding energy density. The energy density is calculated by a corresponding base frequency, a sweep bandwidth of the corresponding base frequency, an emission rate and a total time of emission in a duty cycle, so that the energy waves with the corresponding energy densities effecting on the body of animals or human to reduce inflammation of tissue of animal or human.

Abstract: The present invention is directed to transcutaneous electrical nerve stimulation (TENS) devices which utilize novel stimulation waveforms and novel arrangements of TENS electrodes to improve the efficiency of power consumption while enhancing therapeutic effects.

Abstract: The invention provides systems and methods for monitoring the wellbeing of a fetus by the non-invasive detection and analysis of fetal cardiac electrical activity data.

Abstract: Heart support device for circulatory assistance, with an internal member (6) to be disposed inside a heart lumen (13) and having a dynamic volume body. The internal member (6) has a substantially stiff wall strengthening portion (8) arranged to engage an inner wall surface (12a) of the heart (10) in operation and a dynamic member (9) that is inflatable to assist pumping action of the heart (10).

Abstract: Systems and methods are provided for determining a system response for a neuronal region of interest (ROI). The method comprises positioning an electrode proximate to the neuronal ROI. The electrode is electrically coupled to a neurostimulation (NS) system. The system delivers, from the NS system, a stimulation waveform from the electrode based on NS parameters. The system further programs one or more processors for: measuring an evoked potential waveform resulting from the stimulation waveform; comparing at least one excitation pulse within the stimulation waveform to the evoked potential waveform to obtain a candidate response function; repeating the delivering, measuring and comparing operations to obtain a collection of candidate response functions; and identifying a neuronal system response for the neuronal ROI based on the collection of candidate response functions.

Abstract: A system and method for non-invasively monitoring the hemodynamic state of a patient by determining on a beat-by-beat basis the ratio of lusitropic function to inotropic function as an index of myocardial well-being or pathology for use by clinicians in the hospital or by the patient at home. In one embodiment of the system a smartphone running an application program that is connected through the internet to the cloud processes electronic signals, first, from an electrocardiogram device monitoring electrical cardiac activity, and second, from a seismocardiogram device monitoring mechanical cardiac activity in order to determine such ratio as an instantaneous measurement of the hemodynamic state of the patient, including such states as sepsis, myocardial ischemia, and heart failure.

Abstract: A process for using a retinal photostimulation device involves limiting multiple or repeated uses of the device during a particular treatment cycle. Ordinarily a physician would not want to repeat multiple photostimulation treatments on a patient in a short period time. The process would prevent such retreatment during a single treatment cycle where the retina for any subsequent treatment biometrically matches the retina for an earlier treatment. Such subsequent treatments would be permitted within a predefined period of time after the earlier treatment. Such subsequent treatment may also be permitted where the retinas do not biometrically match.

Abstract: A system and method for regulating water metabolism of cells, which comprises an energy wave generator has an energy wave's frequency control mode. The energy wave's frequency control mode includes multiple controls for acting the energy wave generator to generate and emit energy waves each with a corresponding energy density. The energy density is calculated by a corresponding base frequency, a sweep bandwidth of the corresponding base frequency, an emission rate and a total time of emission in a duty cycle, so that the energy waves with the corresponding energy densities effecting on the body of animals or human to regulate water metabolism of cells of animals or human.

Abstract: A method to provide electrical stimulation therapy to stabilize ventricular rate of a heart during episodes of atrial fibrillation. The stimulation therapy may be a plurality of stimulation pulses delivered to the AV node during the AV node refractory period following the sensing of an atrial event.

Abstract: Systems, devices, and methods are disclosed for limiting the duration of elevated pacing rates in an implantable medical device. An illustrative device may include a housing, a plurality of electrodes connected to the housing, and a controller within the housing and connected to the electrodes. The controller may deliver pacing pulses to the electrodes at a base pacing rate, detect a measure of elevated metabolic demand which may vary over time, deliver pacing pulses at an elevated pacing rate based on the measure of elevated metabolic demand. The controller may change a heart stress tracking value (HSTV) when the pacing rate is elevated and may be changed faster during times of relatively higher elevated pacing rates than times of relatively lower elevated pacing rates. The elevated pacing rate may be reduced back toward the base pacing rate after the HSTV crossed a predetermined heart stress threshold.

Abstract: What is provided is a system, method, and article of manufacture for detecting, monitoring, and tracking whether a user is in a more relaxed or stressed state by measuring the user's heart rate variability. The system has a heart rate monitoring device with at least one sensor that is configured to measure user heart rate. The system also has a mobile computing device, which may be configured to interact with the heart rate monitoring device for monitoring, tracking, and displaying a user's heart rate and mental stress level information. The method measures the user's heart rate information to calculate a measure of heart rate variability and to analyze whether peaks corresponding to activation levels of the user's parasympathetic nervous system (PNS) and sympathetic nervous system (SNS) exceed a predetermined threshold level within a predetermined time period.

Abstract: Some embodiments of the present inventive concept provide a system that uses two wavelengths of differential transmittance through a sample to apply laser speckle or laser Doppler imaging. A first of the two wavelengths is within the visible range that has zero or very shallow penetration. This wavelength captures the anatomical structure of tissue/organ surface and serves as a position marker of the sample but not the subsurface movement of blood flow and perfusion. A second wavelength is in the near Infra-Red (NIR) range, which has much deeper penetration. This wavelength reveals the underlying blood flow physiology and correlates both to the motion of the sample and also the movement of blood flow and perfusion. Thus, true motion of blood flow and perfusion can be derived from the NIR imaging measurement without being affected by the motion artifact of the target.

Abstract: A light detection unit includes a light emitter that emits light toward an object of interest, a light receiver that receives light from the object of interest, and a light blocking member that performs light blocking at least above the light receiver. The light blocking member includes a first surface that is provided between the light emitter and the light receiver and prevents direct light from the light emitter from entering the light receiver and a second surface and a third surface that are provided along a direction that intersects the first surface and prevent light from entering the light receiver. Further, the first surface is made of a first material, and the second surface and the third surface are made of a second material different from the first material.