Patents Examined by Charles Zoltan Constantine
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Patent number: 11970691Abstract: Provided is an immobilized thermostable trehalose synthase including an amino acid sequence of a trehalose synthase domain and an amino acid sequence of a cellulose binding domain. Also provided is a method for converting maltose into trehalose or for converting sucrose into trehalulose by using the immobilized thermostable trehalose synthase.Type: GrantFiled: March 19, 2021Date of Patent: April 30, 2024Assignee: National Taiwan Normal UniversityInventor: Guan-Chiun Lee
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Patent number: 11971337Abstract: Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.Type: GrantFiled: October 4, 2021Date of Patent: April 30, 2024Assignee: VENTANA MEDICAL SYSTEMS, INC.Inventors: James Grille, Brian D. Kelly, Jerome Kosmeder, II, Eric May, Noemi Sebastiao, Pamela Wirth
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Patent number: 11965195Abstract: An enzyme-mediated method for the production of 3a-ethyl-6,6,9a-trimethyldodecahydronaphtho[2,1-b]furan, the products of said method, and uses of said products.Type: GrantFiled: December 3, 2020Date of Patent: April 23, 2024Assignee: GIVAUDAN SAInventors: Eric Eichhorn, Felix Flachsmann
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Patent number: 11939615Abstract: The present invention discloses a production method of enzymatic reaction using adenosine instead of ATP. The method comprises the following steps: (1) adding ATP regeneration enzyme, AK enzyme and adenosine in proportion to carry out an enzymatic reaction in an enzymatic reaction system; (2) separating the ATP regeneration enzyme and AK enzyme by either directly separating ATP regeneration enzyme and AK enzyme immobilized in a reaction tank or separating free ATP regeneration enzyme and AK enzyme by an ultrafiltration membrane in a filter; and (3) separating and purifying the filtrate of step (2) to obtain a product. The disclosed method provides: greatly reduced industrial production costs; faster reaction rate; stable enzyme recovery system that is energy efficient and environmentally friendly; and capability of reusing the byproducts or collecting them for the production of ATP.Type: GrantFiled: June 6, 2018Date of Patent: March 26, 2024Assignee: ANHUI GSH BIO-TECH CO., LTD.Inventors: Shanshan Liu, Hui Liu, Wenwen Zhou, Yongfa Qin
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Patent number: 11891642Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.Type: GrantFiled: November 26, 2019Date of Patent: February 6, 2024Assignee: HYPHA DISCOVERY LIMITEDInventors: Jonathan Charles Paul Steele, Antonio De Riso, Francesco Falcioni, Richard Kerry Phipps, Stephen Keith Wrigley, Emily Jade Hopkins, Aksana Rimu Khan, Tetsuo Kokubun, Kinga Linda Nytko, Vincent Poon, Sebastian Schulz, John Maxim Ward, Mariacristina Bawn
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Patent number: 11879147Abstract: The present invention provides methods of synthesizing trehalose analogues; methods of detecting mycobacteria, and trehalose analogues.Type: GrantFiled: December 17, 2020Date of Patent: January 23, 2024Inventors: Benjamin M. Swarts, Peter Woodruff
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Patent number: 11878040Abstract: The present invention relates to compositions comprising probiotic and prebiotic components, mineral salts, lactoferrin, and possibly saccharomycetes, which perform correct, effective colonisation of the probiotic components administered, with enteric consequences which involve maintaining and/or restoring intestinal health and preventing the consequences of common dysbioses of the digestive tract caused by stress, incorrect dietary habits and antibiotic treatments. Said compositions also have a concomitant anti-inflammatory and immunomodulating action.Type: GrantFiled: August 31, 2022Date of Patent: January 23, 2024Assignee: GLAXOSMITHKLINE CONSUMER HEALTHCARE S.R.L.Inventors: Valeria Longoni, Marisa Penci
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Patent number: 11871771Abstract: Glucosyl Stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The glucosyl Stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavors, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.Type: GrantFiled: May 28, 2019Date of Patent: January 16, 2024Assignee: PureCircle Sdn BhdInventor: Avetik Markosyan
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Patent number: 11851693Abstract: The invention relates to a method for the biotechnological production of the blue-green fungus pigment xylindein from fungus biomass in a bioreactor, the reactor contents being inoculated with biomass that is uncoloured. The invention also relates to the use of uncoloured biomass of the fungus culture Chlorociboria sp. for inoculation in the biotechnological production of the blue-green fungus pigment xylindein.Type: GrantFiled: November 4, 2019Date of Patent: December 26, 2023Assignee: TECHNISCHE UNIVERSITAET DRESDENInventors: Susanne Steudler, Stephanie Stange, Hubertus Delenk, Andre Wagenfuehr, Christof Zeeb, Thomas Walther
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Patent number: 11844365Abstract: Glucosyl Stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl Stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.Type: GrantFiled: July 11, 2016Date of Patent: December 19, 2023Assignee: PureCircle Sdn BhdInventor: Avetik Markosyan
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Patent number: 11817181Abstract: Embodiments of the present disclosure belongs to the technical field of animal feed and provides a method for rapidly evaluating metabolizable energy of goose diet by using a technique of simulative digestion gross energy. By using the technical means combining the biological method and the simulative digestion gross energy technique, metabolizable energy of goose feed can be evaluated quickly. Based on the “stomach-small intestine” two-step enzymatic methods, it is the first time to establish a regression equation between the metabolizable energy change and fiber level in the cecum to rectify the value of simulative digestion gross energy in the cecal microbial digestion phase, making the simulative digestion gross energy technique more reasonable in the assessment of metabolizable energy in geese. Results show that the use of simulative digestion gross energy technique to assess the metabolizable energy of goose feed value is highly feasible.Type: GrantFiled: June 1, 2021Date of Patent: November 14, 2023Assignee: South China Agricultural UniversityInventors: Wence Wang, Lin Yang, Jing Yang, Yongwen Zhu, Hui Ye, Yu Li, Heng Wang, Daiyang Xia, Jianying Chen, Weiqing Ma, Yang Fu, Shanshan Zhu
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Patent number: 11801282Abstract: The present disclosure provides charged lipoprotein complexes that include as one component a negatively charged phospholipid that is expected to impart the complexes with improved therapeutic properties.Type: GrantFiled: January 4, 2017Date of Patent: October 31, 2023Assignee: Abionyx Pharma SAInventor: Jean-Louis Dasseux
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Patent number: 11802302Abstract: The invention provides methods and reagents for detecting luciferase in biological samples. The methods and reagents of the present invention allow detecting fungal luciferase or a functional analog thereof.Type: GrantFiled: January 27, 2020Date of Patent: October 31, 2023Assignee: Light Bio, Inc.Inventors: Il'ya Viktorovich Yampol'Skiy, Valentin Nikolaevich Petushkov, Konstantin Viktorovich Purtov, Natal'ya Sergeevna Rodionova, Mikhail Sergeevich Baranov
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Patent number: 11771724Abstract: Disclosed are compositions and methods for reducing blood alcohol content following alcohol consumption. The inventive compositions and methods rapidly reduce blood alcohol content and alleviate symptoms of intoxication in a subject having an elevated blood alcohol content due to alcohol consumption.Type: GrantFiled: January 14, 2021Date of Patent: October 3, 2023Assignee: LIFE WELL LIVED, LLCInventors: Roxanne Smith, Jonathan Rinker, Kent Howard
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Patent number: 11773422Abstract: Polynucleotide synthesis performed with a substrate independent polymerase such as terminal deoxynucleotidyl transferase (TdT) is regulated by controlling the oxidation state of a metal cofactor. The oxidation state of the metal cofactor is changed to +2, thus activating the polymerase, by applying a voltage with electrodes or by introducing a chemical redox reagent. Addressable polynucleotide synthesis creates polynucleotides with different arbitrary sequences through use of spatial control of cofactor oxidation states to add nucleotides only at selected locations on an array. Control of metal oxidation states is regulated by selective activation of a microelectrode array, controlled addition of redox reagents to specific locations on the array, or controlled activation of photocatalysts at specific locations on the array. Scavengers in solution prevent cofactors distant from the selected locations from catalyzing polymerase activity and thereby maintain the localized effect of polymerase activation.Type: GrantFiled: August 16, 2019Date of Patent: October 3, 2023Assignee: MICROSOFT TECHNOLOGY LICENSING, LLCInventor: Bichlien Hoang Nguyen
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Patent number: 11758905Abstract: The invention belongs to the technical field of nano-drugs, and in particular, relates to an amphotericin B (AmpB) and ?-1,3-glucanase (Gls) loaded bi-functional nano-system with both targets, a preparation method and an application thereof. The nano-system provided by the invention comprises Gls and AmpB loaded chitosan nanoparticles. The ?-1,3-glucanase modified chitosan nanoparticles are constructed for the first time, which can achieve a bi-functional nano-system both targeting fungal biofilm exopolysaccharide ?-1,3-glucan and internal thalli; meanwhile, the ?-1,3-glucanase and the amphotericin B have a synergistic interaction effect, so that the removal capacity is improved. The double-loaded nano-system is used for fungal biofilm damage removal for the first time.Type: GrantFiled: February 22, 2022Date of Patent: September 19, 2023Assignee: QINGDAO AGRICULTURAL UNIVERSITYInventors: Yulong Tan, Su Ma
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Patent number: 11739365Abstract: The present disclosure provides metal nanoparticles for glucose detection, including: metal nanoparticles with glucose oxidase attached; and a cell membrane isolated from erythrocytes, which surrounds the metal nanoparticles, and a glucose detection method using the same.Type: GrantFiled: January 27, 2021Date of Patent: August 29, 2023Assignee: Korea University Research and Business FoundationInventors: Dae Sung Yoon, Insu Kim, Gyudo Lee, Sang Won Lee, Dongtak Lee, Jae Won Jang, Dongsung Park, Heeju Ahn, Hyo Gi Jung, Hoo Seong Lim, Yonghwan Kim
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Patent number: 11717543Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.Type: GrantFiled: June 22, 2020Date of Patent: August 8, 2023Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, ECOLE D'INGENIEURS DE PURPANInventors: Philippe Langella, Sylvie Miquel, Rebeca Martin Rosique, Luis Bermudez Humaran, Muriel Thomas, Harry Sokol, Frédéric Carvalho, Vassilia Theodorou
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Patent number: 11713444Abstract: The present invention relates to nanoparticles and their use to form nanocomposite material, in particular bionanocomposite material, specifically wherein the nanoparticles are formed using plant virus attached to a scaffold of cellulosic material and/or cellulose derived materials, in particular wherein said cellulosic material further comprises plant cell components, for example hemicellulose, pectin, protein or combinations thereof.Type: GrantFiled: April 1, 2016Date of Patent: August 1, 2023Assignee: CelluComp LimitedInventors: Mikhail Talianski, Andrew Love, Eric Whale, David Hepworth, Natalia Petukhova, Jane Shaw
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Patent number: 11702647Abstract: Methods and devices are provided for pretreatment of a sample containing microbial cells. In some embodiments, the pretreatment of the sample is performed via the initial selective lysis, within a sample pretreatment vessel, of non-microbial cells (such as blood cells) and the subsequent centrifugal separation of the sample to remove the resulting debris and concentrate the microbial cells. An immiscible and dense cushioning liquid may be included for collecting the microbial cells adjacent to the liquid interface formed by the cushioning liquid upon centrifugation of the pretreatment vessel. After removal of a substantial quantity of the supernatant, resuspension of the collected microbial cells, and re-establishment of the cushioning liquid interface, at least a portion of the remaining suspension may be removed without substantially removing the cushioning liquid. One or more intermediate wash cycles may be performed prior to extraction of the remaining suspension, which provides a “pretreated” sample.Type: GrantFiled: May 22, 2020Date of Patent: July 18, 2023Assignee: QVELLA CORPORATIONInventors: Samad Talebpour, Aye Aye Khine, Robert Maaskant, Tino Alavie