Abstract: Described are surgical instruments for use in surgical procedures, related methods, systems, and kits, the instruments including features that optionally include one or more specific dimensions, and features that may result in an ergonomic advantage during use.

Abstract: Disclosed are single-incision surgical procedures for treatment of urinary incontinence and/or pelvic floor disorders and related uses, devices, kits, and methods. Implants are also disclosed for use in the exemplary procedures. In certain embodiments, soft tissue anchors are used to anchor the surgical implants to obturator membranes of a patient.

Abstract: The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.

Abstract: A position detecting apparatus includes receiving antennas to receive a radio signal, transmitting antennas to transmit a radio signal for power supply to a capsule endoscope, a first and second linear magnetic field generators that generate first and second linear magnetic fields, a diffuse magnetic field generator that generates a diffuse magnetic field, a processing device that performs a predetermined process on the radio signal, and a magnetic field sensor that functions as a body-size information detector. The magnetic field sensor detects magnetic field strength at an arranged position as body-size information, and the processing device controls the first linear magnetic field generator based on the magnetic field strength detected by the magnetic field sensor. Thus, the position detecting apparatus is capable of generating a magnetic field for position detection having an optimal strength according to a difference in body sizes of subjects.

Abstract: Devices, systems and methods are provided for stabilizing and grasping tissues such as valve leaflets, assessing the grasp of these tissues, approximating and fixating the tissues, and assessing the fixation of the tissues to treat cardiac valve regurgitation, particularly mitral valve regurgitation.

Abstract: A method for treating urinary incontinence includes the steps of inserting into the woman's vagina a first disposable device, removing the first disposable device, and inserting a second disposable device substantially identical to the first disposable device. The disposable devices have a working portion with opposed faces to provide support to an associated urinary system and, optionally, an anchoring portion to maintain the disposable device in place during use. The working portion also has. The working portion also has an insertion equivalent diameter ranging from about 10 to about 25 mm and a use equivalent diameter ranging from about 25 to about 35 mm under an expansion pressure of about 20 to about 150 cm H2O.

Abstract: A self-regulating gastric band apparatus for adjusting stoma size is disclosed. The apparatus includes an adjustable gastric band that has an expandable portion containing a volume of fluid. A band adjustment assembly is provided for implanting with the gastric band that includes a sensor for sensing fluid pressure in the expandable portion. The band adjustment assembly further includes a pump assembly connected to the expandable portion and to a controller that can operate the pump assembly to adjust the volume of the fluid in the band based on the sensed fluid pressure. The band adjustment assembly includes memory storing an operating range relative to a target fluid pressure, and the pump assembly is operated to maintain the sensed band pressure within the operating range. The target pressure is set to maintain pressure variations below a predefined variation limit generally corresponding with satiated fill volumes for a particular patient and implanted band.

Abstract: A radio-nuclear material delivery system includes: a body; at least one catheter including a portion arranged within the body and extending along a longitudinal length of the body, each catheter including a blind lumen in which a radioactive material is insertable; and a shield arranged on an exterior of the body and movable along the body in a longitudinal direction of the catheter. The shield may be made of a tungsten material, e.g., coated with titanium nitride, for attenuating radiation from the nuclear material and controlling dosing of radiation for treatment of, e.g., breast cancer.

Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

Abstract: A system, kit, and pet bed for treating tissue using magnetic coils connected to a pulse generator. The system can include a power supply, a bi-directional communication and power port, a microcontroller, a processor, a data storage, and a Helmholtz-like magnetic coil pair. The kit can include a saddlebag and a support strap. The pet bed can include bedding, a fabric housing, a Halbach array, and an on/off switch.

Abstract: An implantable vessel occlusive device and method for occluding a vessel are described, for example to occlude the urethra or bladder neck. The devices and methods described utilize an occlusive member connected to a control mechanism. The occlusive member is reversibly changed from a non-occlusive condition to an occlusive condition, for example by depressing an activation button contained within a resilient, elastomeric cover surrounding the control mechanism. In the occlusive position, an initial tension is applied to the occlusive member through a tensioning suture. The tension is translated into an occlusive pressure applied to the urethra or bladder neck that is sufficient to prevent urinary leakage. The non-occlusive position can be obtained by depressing the de-activation button. The occlusive member is constructed to allow elution of drugs, such as may be required to combat infection or tissue encapsulation from its surface.

Abstract: A remotely controllable gastric banding device (10) for placement around the stomach of a patient for the treatment of obesity. The device (10) comprises a gastric band (10) having an inflatable chamber (16) for adjusting the inner circumference of the band (10), a pressurized reservoir (20) with a valve (31) for providing fluid to inflate the inflation chamber (16), a valve (32) for releasing fluid from the inflatable chamber (16), and a controller (41) for controlling the valves (31, 32). The controller (41) is remotely controllable from outside the patient.

Abstract: An apparatus for creating therapeutic charge transfer in tissue includes a coil. The coil generates a changing magnetic field to induct an electric field in the tissue exceeding 10 mV/cm when the coil is 5 cm from the tissue. Preferably, the magnetic field has a growth phase and a decay phase and a duration of the growth phase is at least ten times a duration of the decay phase. The apparatus can include a control circuit to control a current fed to the coil. The control circuit includes two subcircuits and a switch for switching between a first of the subcircuits and a second of the subcircuits; preferably, a ? of the second subcircuit is at least ten times a ? of the first subcircuit. To generate the therapeutic effect, the coil should have a duty cycle of at least ten percent.

Abstract: Endoscopic subxiphoid surgical procedures and instruments facilitate translumination of tissue through the pericardium, and promote encircling an intrapericardial region with one or more tissue-ablating probes for ablating cardiac tissue substantially encircling the left and right pulmonary veins as a treatment for chronic atrial fibrillation. Such endoscopic subxiphoid surgical procedures and instruments also facilitate placement of epicardial tacks about the annulus of the mitral valve for supporting a tensioned suture or band that decreases the size of the mitral annulus to repair a regurgitant valve. Suction-oriented instruments facilitate temporary attachment to an organ to establish precise positioning on the organ during a surgical procedure.

Abstract: A method and apparatus are disclosed for treating a condition of a patient's airway. The condition is attributed at least in part to a spacing of tissue from opposing surfaces in the airway. In one embodiment, the method and apparatus include placing a tissue contractor within the tissue. The contractor includes a static end and a tissue in-growth engaging end. The static end is secured to a bony structure adjacent to tissue to be contracted. The tissue in-growth engaging end is secured to the tissue and spaced from the bony structure. A spacing between the tissue engaging end and a bony end is contracted in order to place the tissue under tension.