Patents Examined by Christopher James Nichols
  • Method of diagnosing ischemic stroke via UCP-2 detection
    Patent number: 6670138
    Abstract: The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: December 30, 2003
    Assignee: AGY Therapeutics, Inc.
    Inventors: Mirella Gonzalez-Zulueta, Mehrdad Shamloo, K.C. McFarland, Daniel Chin, Tadeusz Wieloch, Thorsten Melcher
  • Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth
    Patent number: 6670179
    Abstract: A cell and substrate system and nerve regeneration implant are disclosed including a carbon nanotube and a neuron growing on the carbon nanotube. Both unfunctionalized carbon nanotubes and carbon nanotubes functionalized with a neuronal growth promoting agent may be utilized in the invention. A method is also disclosed for promoting neuronal growth.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: December 30, 2003
    Assignee: University of Kentucky Research Foundation
    Inventors: Mark P. Mattson, Robert C. Haddon, Apparao M. Rao
  • Methods of using geldanamycin and FK506 to treat peripheral nerve damage
    Patent number: 6641810
    Abstract: FK506 and geldanamycin promote nerve regeneration by a common mechanism that involves the binding of these compounds to polypeptide components of steroid receptor complexes other than the steroid hormone binding portion of the complex (FKBPS52 and hsp90, respectively). These and other agents cause hsp90 dissociation from steroid receptor complexes or block association of hsp90 with steroid receptor complexes.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: November 4, 2003
    Assignee: Oregon Health & Science University
    Inventor: Bruce G. Gold
  • Method of conferring 9-CIS retionic acid reponsiveness
    Patent number: 6617120
    Abstract: This invention provides an isolated receptor having the amino acid sequence of FIG. 1 (SEQ ID NO:2) or substantially the same amino acid sequence as the amino acid sequence shown in FIG. 1 (SEQ ID NO:2) or an amino acid sequence functionally similar to that sequence, and DNA sequences encoding such a receptor.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: September 9, 2003
    Assignee: Karo Bio AB
    Inventors: Eva L. K. Enmark, Jan-Ake Gustafsson
  • Reconstructed laminae of human epithelium corneae and method of producing the same
    Patent number: 6610538
    Abstract: A method of reconstructing laminae of human epithelium corneae in vitro to be used in grafts from cultures of limbar stem cells as well as a method of selecting and transferring such cells to fibrin substrate.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: August 26, 2003
    Assignee: Provincia Italiana Della Congregazione Dei Figli Dell' Immacolata Concezione - Istituto Dermopatico Dell' Immacolata
    Inventors: Michele De Luca, Graziella Pellegrini