Abstract: A process for reducing the levels of undesirable impurities in a mesotrione sample is disclosed, said process comprising the steps of: (i) forming a mesotrione enolate solution in an aqueous solvent, (ii) carrying out one or more purification processes, and (iii) crystallizing the purified mesotrione out of solution.
Type:
Grant
Filed:
October 1, 2004
Date of Patent:
October 26, 2010
Assignee:
Syngenta Crop Protection, Inc.
Inventors:
Julie Marie Wichert, Alan Henry Benke, Regine Laure Guidetti-Grep
Abstract: Novel processes for preparing arylsulfur pentafluorides are disclosed. Processes include reacting at least one aryl sulfur compound with a halogen and a fluoro salt to form an arylsulfur halotetrafluoride. The arylsulfur halotetrafluoride is reacted with a fluoride source to form a target arylsulfur pentafluoride.
Abstract: A vector for targeted delivery of drugs into estrogen receptors over-expressed cells is disclosed. The vector of the present invention is mainly about an active targeting delivery carrier which consists of a plurality of nanoparticles including: (i) a plurality of targeted moiety conjugated to the outer surface of the nanoparticles, the moiety being capable of binding with the estrogen receptor of a target cell, and (ii) bioactive agents encapsulated in the nanoparticles or forming complex with the nanoparticles. The targeted moiety of the present invention can also be conjugated to parent drugs for prodrug design.
Type:
Grant
Filed:
December 30, 2003
Date of Patent:
October 26, 2010
Assignee:
Industrial Technology Research Institute
Inventors:
Shyh-Dar Li, Ae-June Wang, Chung-Kung Lai
Abstract: A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
Type:
Grant
Filed:
February 19, 2009
Date of Patent:
October 26, 2010
Assignee:
Health Research, Inc.
Inventors:
Ravindra K. Pandey, Amy Gryshuk, Lalit Goswami, William Potter, Allan Oseroff
Abstract: The invention relates to compounds having the general formula (I), the method of preparation thereof and the use thereof in organic radical synthesis. The invention also relates to compounds having the formula (II), the method of preparation thereof and a method for preparing compounds having the formula (VIII).
Type:
Grant
Filed:
August 6, 2008
Date of Patent:
October 26, 2010
Assignee:
Centre National de la Recherche Scientifique (CNRS)
Abstract: A process for the catalytic hydrogenation or asymmetric hydrogenation of imines of Formula (I) to the corresponding amines of Formula (II) is provided in which R1 is aryl; R2 is aryl, cyclic, alkyl, alkenyl or alkynyl; and R3 is alkyl. The catalytic system includes a ruthenium complex containing (1) a diamine and (2) a diphosphine or two monodentate phosphines ligands. Such process also relates to the asymmetric hydrogenation of prochiral imines to the chiral amines using chiral ruthenium complexes bearing chiral diphosphines or chiral monodentate phosphines and chiral diamines.
Abstract: A method for purifying organosilicon precursor compounds is provided. It includes preparation of the adsorbent with a treating compound. The thus-treated adsorbents can be used to remove impurities such as organic impurities and moisture from a composition containing an organosilicon containing compound. In this manner, it is able to purify organosilicon precursors (or solutions containing organosilicon precursors) without inducing decomposition of the organosilicon precursor.
Abstract: A compound of formula 8 and uses thereof in various electronic devices and in a formulation for ink jet printing and in an organic semiconducting layer formulation.
Type:
Grant
Filed:
February 6, 2007
Date of Patent:
October 5, 2010
Assignee:
Merck Patent GmbH
Inventors:
Beverley Anne Brown, Janos Veres, Remi Manouk Anemian, Richard Williams, Simon Dominic Ogier, Stephen William Leeming
Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
Abstract: The invention relates to sulfur silane coupling agents containing multiple blocked mercapto groups which are in a state of reduced activity until activated. The coupling agents are advantageously used in rubber formulations, for example, for fabricating tires with low rolling resistance.
Type:
Grant
Filed:
December 28, 2006
Date of Patent:
August 24, 2010
Assignee:
Momentive Performance Materials Inc.
Inventors:
Richard W. Cruse, W. Michael York, Eric R. Pohl, Antonio Chaves, Tiberiu L. Simandan, Prashant Joshi
Abstract: The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent.
Abstract: Described are polymeric surfactants which include a fluorinated moiety and a non-fluorinated moiety where the fluorinated moiety contains two perfluoro-lower-alkyl sulfonamido segments in proximity to each other ; the surfactants provide more efficient and effective lowering of the surface tension of liquids and increase of wetting of a coating on a substrate surface.
Type:
Grant
Filed:
December 30, 2004
Date of Patent:
August 17, 2010
Assignee:
3M Innovative Properties Company
Inventors:
Michael S. Terrazas, George G. I. Moore, Michael J. Sierakowski, Rudolf J. Dams
Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.
Type:
Grant
Filed:
June 17, 2004
Date of Patent:
August 10, 2010
Assignees:
Yissum Research Development Company of The Hebrew University of Jerusalem, Biolab Ltd.
Inventors:
Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
Abstract: A novel process for preparing in a high purity and in a high yield phosphonates having a secondary and/or tertiary alcoholic hydroxyl group at the end of a P—C bond chain thereof with the use of a phosphite and a carbonyl compound as raw materials.
Abstract: Process for preparing aminodihalophosphines, diaminohalophosphines, triaminophosphines, phosphorous ester diamides, aminophosphines, diaminophosphines, phosphorous ester amide halides and aminophosphine halides with elimination of an acid in the presence of an auxiliary base, wherein the auxiliary base b) and the acid form a salt which is liquid at temperatures at which the desired product is not significantly decomposed during the process of separating off the liquid salt and c) the salt of the auxiliary base forms two immiscible liquid phases with the desired product or the solution of the desired product in a suitable solvent.
Type:
Grant
Filed:
January 21, 2003
Date of Patent:
August 3, 2010
Assignee:
BASF Aktiengesellschaft
Inventors:
Martin Volland, Verena Seitz, Matthias Maase, Miguel Flores, Rainer Papp, Klemens Massonne, Veit Stegmann, Klaus Halbritter, Ralf Noe, Michael Bartsch, Wolfgang Siegel, Michael Becker, Oliver Huttenloch
Abstract: Processes comprising: providing an aromatic alcohol; and reacting the aromatic alcohol with ammonia at a temperature of 80 to 350° C. in the presence of hydrogen and a heterogeneous catalyst to form a crude reaction product comprising a corresponding primary aromatic amine, wherein the heterogeneous catalyst comprises a catalytically active composition which, prior to reduction with hydrogen, comprises 90 to 99.8% by weight of zirconium dioxide (ZrO2), 0.1 to 5.0% by weight of an oxygen-comprising compound of palladium, and 0.1 to 5.0% by weight of an oxygen-comprising compound of platinum.
Type:
Grant
Filed:
June 21, 2006
Date of Patent:
August 3, 2010
Assignee:
BASF SE
Inventors:
Frank Haese, Joachim Wulff-Doering, Ulrich Koehler, Peter Gaa, Frank-Friedrich Pape, Johann-Peter Melder, Manfred Julius
Abstract: The present invention relates to a process for preparing organophosphites, organophosphonites and organophosphinites by condensing phosphorus trihalides or organophosphorus halides with organic compounds bearing hydroxyl groups in the presence of polymeric basic ion exchange resins. The process according to the invention makes possible in a simple manner the preparation of trivalent organophosphorus compounds which may be used, for example, as ligands in rhodium complexes which may be used as a catalyst in hydroformylation.
Type:
Grant
Filed:
October 29, 2004
Date of Patent:
August 3, 2010
Assignee:
Evonik Oxeno GmbH
Inventors:
Dagmara Ortmann, Klaus-Diether Wiese, Oliver Moller, Dirk Fridag
Abstract: The invention provides polymers, methods of preparing polymers, and compositions that include polymers, wherein said polymers include a plurality of two-carbon repeating units in a polymer chain, wherein one or more of the two-carbon repeating units of the polymer chain have tertiary amine or pyridine-containing substituents; and at least about 10% of the nitrogen atoms of the tertiary amine or pyridine-containing substituents are quaternized with alkyl groups or with an alkyl group that contains one or more ethylene glycol groups. The alkyl or ethoxylated alkyl groups can also be at least partially fluorinated. The polymers can be used to provide antimicrobial surfaces and antifouling coatings.
Type:
Grant
Filed:
August 21, 2006
Date of Patent:
July 27, 2010
Assignee:
Cornell Research Foundation, Inc.
Inventors:
Christopher K. Ober, Sitaraman Krishnan, Qin Lin, Edward Kramer
Abstract: The invention relates to a continuous process for the preparation of phenol by means of the direct oxidation of benzene with hydrogen peroxide in the presence of a catalyst based on titanium silicalite TS-1 comprising: (a) running the process in a fixed bed reactor containing the catalyst based on TS-1 at a temperature ranging from 80-120° C. and at a pressure ranging from 3-15 atm; (b) feeding to the reactor a stream containing H2O2, benzene, sulfolane and water in a single or double phase, wherein the quantities of the single components are within the range of 0.2-6, 15-60, 30-80, 0.5-30 parts by weight, respectively, for every 100 units fed and whose total flow rate is calculated so that the residence time in the reactor (defined as the ratio between the quantity of catalyst by weight and the feeding flow rate) ranges from 0.3 to 2 min; (c) recovery of the products, by-products and solvent from the liquid stream leaving the reactor.