Abstract: The present invention provides a method of treating anxiety and related disorders using an agonist which acts at negatively coupled cAMP-linked metabotropic glutamate receptors.
Type:
Grant
Filed:
January 21, 1997
Date of Patent:
March 16, 1999
Assignee:
Eli Lilly and Company
Inventors:
David Reed Helton, Mary Jeanne Kallman, James Allen Monn, Darryle Darwin Schoepp, Joseph Patrick Tizzano
Abstract: The invention provides a clathrate comprising a cyclodextrin or hydroxyalkylated cyclodextrin and, as included therein, dl-.alpha.-tocopheryl L-ascorbyl phosphate. In another aspect, the invention provides a dermal composition for external use, particularly a cosmetic composition. The composition is characterized by reduced foam production in aqueous solution and good stability against light.
Abstract: Cosmetic composition, in particular one for making up the eyes, comprising:(a) at least one aqueous phase comprising at least one film-forming polymer,(b) at least one fatty phase comprising at least one wax, and(c) at least one silicone selected from the group consisting of:(i) oxyalkylenated silicones, and(ii) linear polysiloxane-polyoxyalkylene block copolymers.
Abstract: A composition containing a dermatologically acceptable carrier in admixture with molecular oxygen promotes and improves respiratory function of skin cells. The composition may be used in cosmetic compositions.
Abstract: A cream formulation for topical application to an external portion of a human body. A one ounce preparation of such cream formulation includes active ingredients consisting essentially of a predetermined weight of an aloe vera gel compound present in the topical formulation generally in a weight range of between about 3 grams and about 10 grams. A predetermined weight of a preselected zinc compound present in the topical formulation generally in a weight range of between about 0.4 gram and about 1.5 grams. A predetermined weight, expressed as IU, of vitamin E present in the topical formulation generally in a weight range of between about 200 IU and about 9000 IU. The balance of such one ounce preparation of the topical formulation being made up of water, organic solvents, carriers and emollients.
Abstract: Multi-vitamin and mineral supplements for administration to lactating, non-lactating, and menopausal women, which comprise specific regimens of critical nutritional agents. The supplements are specifically tailored to meet nutritional requirements and maintain a woman's health during each stage of life.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
February 9, 1999
Assignee:
K-V Pharmaceuticals Co.
Inventors:
George N. Paradissis, R. Saul Levinson, Gary Heeter, Robert C. Cuca, Patrick Paul Vanek
Abstract: The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly when placed in the mouth. The compositions typically include partially hygroscopic shearform matrices which may be recrystallized using crystallization promoters.
Type:
Grant
Filed:
August 20, 1997
Date of Patent:
February 9, 1999
Assignee:
Fuisz Technologies LTD.
Inventors:
Tushar K. Misra, Jeffery W. Currington, Satish V. Kamath, Pradeep P. Sanghvi, John R. Sisak, Michael G. Raiden
Abstract: The present invention relates to a composition for making up the eyelashes and the eyebrows, consisting of a fatty phase based on wax(es) of melting point between 50.degree. and 110.degree. C. and of an aqueous phase based on water-soluble film-forming polymer(s) in solution, containing as emulsifying agent and agent for inhibiting the growth of microorganisms, a mixture comprising at least one oxyethylenated glyceryl (C.sub.10 -C.sub.20) acylate and at least a second oxyethylenated glyceryl (C.sub.10 -C.sub.20) acylate or a non-oxyethylenated glyceryl acylate, which are chosen such that the final HLB, in the Griffin sense, of the said mixture is between 6 and 15, and containing from 0 to 14% by weight of wax(es) I having a needle penetration at 25%, according to the Reinhold standard, between 1 and 7.5 and from 2 to 40% by weight of wax(es) II having a needle penetration at 25%, according to the Reinhold standard, between 7.5 and 217; the wax(es) I/wax(es) II weight ratio being less than 2.
Type:
Grant
Filed:
August 26, 1997
Date of Patent:
February 2, 1999
Assignee:
L'Oreal
Inventors:
Bertrand Piot, Sylvie Sirugue, Jeanne Patraud, Marie Jose Martin
Abstract: A body polisher and method of using the body polisher as a skin treatment, includes a two phase composition containing Dead Sea salt and emollient. The emollient is advantageously silicone oil and is present in about 32.67% by weight. About 66.66% by weight Sea salt is provided, the remainder being fragrance.
Abstract: The following invention introduces a patch preparation for treating plants, whereas the patch preparations comprise a chemical layer composed of at least one agrochemically active compound, at least one adhesive and optionally, one or more additives. The components are dispersed in a matrix state on a substrate which are then introduced on the roots of the plant to be treated.
Abstract: A thickening system containing an amorphous silica and xanthan gum in a silica/xanthan gum weight ratio from 160:1 to 2:1, preferably 100:1 to 5:1, most preferably 30:1 to 6.5:1 can be used to stabilise and thicken cosmetic compositions containing alpha-hydroxy carboxylic acids.
Abstract: By providing a neutralizing solution formulated with an alkaline pH, for use with a conventional reducing lotion, a long-lasting, permanently waved head of hair is attained. Furthermore, by employing the neutralizing solution of the present invention, substantially reduced hair damage and substantially improved curl retention and formation is attained. In the preferred embodiment, the alkaline pH neutralizing solution of the present invention is attained by employing a bromate salt in combination with at least one pH adjusting agent. If desired, hair conditioning and wave enhancing additives may also be employed. Preferably, the bromate salt employed comprises one selected from the group consisting of sodium bromate and potassium bromate, with sodium bromate.
Type:
Grant
Filed:
April 30, 1996
Date of Patent:
December 22, 1998
Assignee:
Shiseido Co., Ltd.
Inventors:
Edward Borish, Judith A. Cohee, Andrew Savaides
Abstract: A method is provided for reducing the incidence of otitis media in infants and young children by enterally administering indigestible fructooligosaccharides. More specifically, the present invention relates to a method for reducing the incidence of otitis media comprising administering to humans an indigestible fructooligosaccharide selected from the group consisting of 1-kestose, nystose and 1-.sup.F -B-fructofuranosyl nystose . The indigestible fructooligosaccharides can be produced through enzymatic synthesis, chemical techniques or isolated from plant materials and are administered in the form of a nutritional product, candy, tablets, chewing gums, lozenges, milk products, yogurts and the like. In a preferred embodiment of this invention, the fructooligosaccharides have a DP of 2 to 20 and still more preferably are the fructooligosaccharides FG.sub.2, GF.sub.3, and GF.sub.4.
Type:
Grant
Filed:
June 12, 1996
Date of Patent:
December 15, 1998
Assignee:
Abbott Laboratories
Inventors:
Margaret Ione Halpin Dohnalek, Karin Margaret Ostrom, Milo Duane Hilty
Abstract: A skin treatment composition is provided which includes a crosslinked non-emulsifying siloxane elastomer, a skin conditioning agent, a volatile siloxane and no more than 5% water. Hydrocarbons such as petrolatum and polyols such as glycerin are the preferred skin conditioning agents. Inclusion of the elastomer provides a non-traditional smooth/silky feel to the skin upon application with a non-draggy rub in.
Type:
Grant
Filed:
March 20, 1997
Date of Patent:
December 15, 1998
Assignee:
Chesebrough-Pond's USA Co., Division of Conopco, Inc.
Inventors:
Brian John Dobkowski, Alexander Paul Znaiden, Michael Charles Cheney, Walter Rose
Abstract: The present invention pertains to chewing gum compositions containing cough suppressing agents. The compositions include a taste-masking mixture containing a flavoring agent, an intense sweetening agent and menthol. This combination nullifies the taste or off-note of the cough suppressant. The present invention also pertains to a method preparing the chewing gum composition and methods of treatment which include administering the cough suppressant-containing chewing gum to a patient in need thereof.
Type:
Grant
Filed:
June 30, 1997
Date of Patent:
December 8, 1998
Assignee:
Cumberland Packing Corporation
Inventors:
Barbara Eisenstadt, Penny A. Cash, Abraham I. Bakal
Abstract: A composition in the form of an anhydrous gel containing a wax-free fatty phase in which are dispersed an organomodified clay, expanded thermoplastic hollow particles of polymer or copolymer formed from a monomer or a mixture of monomers containing ethylenic unsaturation and a pyrogenous silica, as well as to its uses in topical application.This composition has a creamy, non-greasy, smooth and melting texture and good stability over time.It may be used as a base for make-up products or care products for the skin and/or the face. It may contain heat-sensitive cosmetic or dermatological active agents.
Type:
Grant
Filed:
May 30, 1996
Date of Patent:
December 8, 1998
Assignee:
L'Oreal
Inventors:
Martine Perrin, Nadia Terren, Jacques Michelet
Abstract: A composition for a topically healing ointment having all natural herbs and an animal fat base. The combination of which forms a salve that is active against one or a combination of sources of viral, bacterial and fungus infections that have the ability to penetrate beneath the epidermal layer of the skin.
Abstract: Novel pharmaceutical compositions comprising a chemotherapeutic agent and a polyether block copolymer, and methods of treatment using the compositions.
Type:
Grant
Filed:
October 15, 1997
Date of Patent:
November 24, 1998
Inventors:
Valery Yu Alakhov, Alexander V. Kabonov, Peter G. Sveshnikov, Eugenii S. Severin
Abstract: The invention provides a chewing gum composition containing a water soluble bulk portion, a water insoluble chewing gum base portion, a flavoring agent, and bismuth-containing compounds. The invention provides a bismuth-containing gum which when chewed multiple times per day, over the period of two weeks, is effective in reducing peptic ulcers by eradicating H. pylori. The chewing gum is also effective in eliminating forms of halitosis. The chewing gum does not have undesirable side effects, unpleasant taste and poor chewing characteristics.
Abstract: Microparticulate carrier materials for a large and varied group of pharmaceutical and cosmetic agents are disclosed. Microdispersions of such carrier materials charged with at least one isomer or derivative of 2-amino-1-phenylpropanol are also described. The microdispersions can be formulated for oral, parenteral, topical, inhalation and suppository administration. The formulations have varied uses depending on the pharmaceutical and or cosmetic agent utilized. The microparticles are suitably charged particles of silica, alumina, boron, charcoal and the like and have a particle size of about 3 to about 250 .mu.m. The pharmaceutical and cosmetic active materials complex with the microparticles. The liquid carrier for the microparticles include water, propylene glycol, alcohols such as methanol, ethanol and propanols, and dimethyl sulfoxide.
Type:
Grant
Filed:
May 21, 1997
Date of Patent:
November 3, 1998
Inventors:
Daniel David West, Richard Breitbarth, deceased, by Amy Martrildonno, administratrix