Patents Examined by D. L. Jones
  • Hsp9O-targeted inflammation and infection imaging and therapy
    Patent number: 10617772
    Abstract: The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: April 14, 2020
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Mark Dunphy, Gabriela Chiosis
  • Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders
    Patent number: 10596116
    Abstract: Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: March 24, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Wenbin Lin, Demin Liu, Joseph Della Rocca, Stephanie Kramer, Christopher Y. Poon
  • Gas-generating nanoparticle
    Patent number: 10576170
    Abstract: Disclosed are gas-generating nanoparticles comprising fine-grained calcium carbonate crystals and a biocompatible polymer, the fine-grained calcium carbonate crystals being encapsulated inside the biocompatible polymer, and the diagnosis and treatment of diseases can be effectively performed at the same time by using a composition of the present disclosure.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: March 3, 2020
    Assignee: supernova bio Co., Ltd
    Inventors: Kuen Yong Lee, Jang Wook Lee
  • Protease-activated contrast agents for in vivo imaging
    Patent number: 10570173
    Abstract: Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: February 25, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew S. Bogyo, Martijn Verdoes, Leslie Ofori, Nimali P. Withana
  • F labeling of proteins using sortases
    Patent number: 10556024
    Abstract: The present invention, in some aspects, provides methods, reagents, compositions, and kits for the radiolabeling of proteins, for example, of proteins useful for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) (e.g., for diagnostic and therapeutic applications), using sortase-mediated transpeptidation reactions. Some aspects of this invention provide methods for the conjugation of an agent, for example, a radioactive agent or molecule to diagnostic or therapeutic peptides or proteins. Compositions comprising sortagged, radiolabeled proteins as well as reagents for generating radiolalebed proteins are also provided. Kits comprising reagents useful for the generation of radiolabeled proteins are provided, as are precursor proteins that comprise a sortase recognition motif.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: February 11, 2020
    Assignees: Whitehead Institute for Biomedical Research, The General Hospital Corporation
    Inventors: Mohammad Rashidian, Hidde L. Ploegh, Ralph Weissleder, Edmund J. Keliher
  • Compositions and methods for visualization of the vitreous
    Patent number: 10537648
    Abstract: The invention provides compositions for rendering a vitreous cavity visible during a surgical procedure to alleviate a structural disorder caused by the vitreous in an eye, and methods of using the compositions. The compositions are vitreous delineating agents that comprise a hyaluronan binding peptide linked to an optically detectable moiety. Such compositions can be in a formulation that may be a solution, a suspension, or an emulsion, and would be injected into the vitreous shortly prior to use. The composition may additionally contain a therapeutic agent, a diagnostic agent, or a chemosensing material, in use, the composition marks or delineates the vitreous by binding preferentially to the hyaluronan that permeates the vitreous humor and binding little or not at all to surrounding tissues such as the retina.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: January 21, 2020
    Assignee: Novartis AG
    Inventors: Joy Ghosh, Thaddeus Peter Dryja, Michael Roguska, Eric C. Carlson
  • Tin-117m somatostatin receptor binding compounds and methods
    Patent number: 10537651
    Abstract: Tin-117m somatostatin analogues or antagonist are used to treat tumors and symptoms associated with these tumors which express somatostatin receptors, such as gastroenteropancreatic neuroendocrine tumors. The tin-117m somatostatin receptor binding compounds can be administered at a dosage which is effectively apoptotic and not necrotic. Also, if desired, it can be administered at a dose that is necrotic and/or induces necrosis, but only to cells within 290 microns of the tin-117m atom. A novel somatostatin analogue is also disclosed, as well as novel methods to produce the tin labeled analogues and antagonists.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: January 21, 2020
    Assignee: Serene, LLC
    Inventors: Nigel R. Stevenson, Jaime Simon, Gilbert R. Gonzales
  • Labelled silica-based nanomaterial with enhanced properties and uses thereof
    Patent number: 10520500
    Abstract: The present invention relates to labelled silica-based nanoparticles with enhanced properties, to process for preparing them and to uses thereof.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: December 31, 2019
    Inventors: Abdeslam El Harrak, Victoire Goust, Andrew David Griffiths, Thomas Mangeat
  • Methods and kits for diagnosis of cancer and prediction of therapeutic value
    Patent number: 10517969
    Abstract: A method for identifying a patient for cancer therapy can include administering a diagnostic dose of a detectably labeled first binding agent to a patient, the detectably labeled binding agent being capable of binding a molecular target. The method also includes selecting a patient for administration of a therapeutic dose of a second binding agent capable of binding a cellular target, wherein the selected patient exhibits a positive reading for the detectably labeled first binding agent. Furthermore, the method can include administering a therapeutic dose of the second binding agent to the patient.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: December 31, 2019
    Assignee: CORNELL UNIVERSITY
    Inventors: Neil H. Bander, Joseph Osborne, Stanley J. Goldsmith, Shankar Vallabhajosula
  • Systems and methods for targeted imaging and ablation of cardiac cells
    Patent number: 10512691
    Abstract: The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety; and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: December 24, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jerome Kalifa, Raoul Kopelman, Uma Mahesh R. Avula, Gwangseong Kim, Yong-Eun Koo Lee, Hyung Ki Yoon
  • Optical probes for matrix metalloproteinases
    Patent number: 10507247
    Abstract: An optical probe is presented comprising at least one fluorophore connected to at least one quencher by an enzyme cleavable peptide sequence; the or each fluorophore being substantially fluorescently quenched by the at least one quencher when connected to the enzyme cleavable peptide sequence; the or each fluorophore is separated from the at least one quencher when the enzyme cleavable peptide sequence of the at least one probe element is cleaved; and the enzyme cleavable peptide sequence is selectively cleavable by one or more matrix metalloproteinase (MMP). Methods of use of the optical probe are also presented.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 17, 2019
    Assignee: The University of the University of Edinburgh
    Inventors: Mark Bradley, Sunay Vijaykumar Chankeshwara, Alicia Megia-Fernandez
  • Cleavable lipids
    Patent number: 10507183
    Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: December 17, 2019
    Assignee: Translate Bio, Inc.
    Inventors: Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
  • Collagen targeted imaging probes
    Patent number: 10471162
    Abstract: Disclosed herein are collagen-targeted imaging agents for positron emission tomography and related imaging methods using the collagen-targeted imaging agents. The collagen-targeted imaging agent is a cyclic polypeptide comprising a cyclic main body, wherein the cyclic main body comprises at least one S—S bond; at least two branches, wherein each of the at least two branches comprises at least three amino acids; and a linker, wherein the linker is capable of linking an imaging reporter.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: November 12, 2019
    Assignee: The General Hospital Corporation
    Inventors: Pauline Desogere, Peter Caravan
  • Activatable fibrin-binding probes
    Patent number: 10471163
    Abstract: Provided herein are methods for determining the presence or absence of active thrombus formation using a linear polypeptide that binds fibrin upon cyclization. Also provided are compounds comprising linear polypeptide probes that are cyclized in the presence of protein disulfide isomerase.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: November 12, 2019
    Assignee: The General Hospital Corporation
    Inventors: Galen Loving, Peter D. Caravan
  • 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
    Patent number: 10473658
    Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: November 12, 2019
    Assignee: VisEn Medical, Inc.
    Inventor: Narasimhachari Narayanan
  • Enhanced in vivo targeting of radiolabelled peptides with the means of enzyme inhibitors
    Patent number: 10449260
    Abstract: The present invention relates to a compound that inhibits the activity of a degrading enzyme for use in combination with a therapeutic or diagnostic compound, preferably a moiety conjugated peptide, in the diagnosis and/or treatment of a disease, in particular cancer, to enhance targeting of the therapeutic or diagnostic compound to the disease site.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: October 22, 2019
    Inventors: Theodosia Maina-Nock, Berthold Artur Nock, Marion de Jong Hendriks
  • Compositions targeting radiation-induced molecules and methods of use thereof
    Patent number: 10449261
    Abstract: The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: October 22, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventor: Dennis E. Hallahan
  • Pre-and-intra-operative localization of penile sentinel nodes
    Patent number: 10434190
    Abstract: The invention provides methods for pre- and intra-operatively localizing penile sentinel lymph nodes by injection of fluorescent dyes into penile tumors.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: October 8, 2019
    Assignee: NOVADAQ TECHNOLOGIES ULC
    Inventors: Dragan Golijanin, Lukasz Brzozowski, Ronald Wood
  • Optical imaging probes
    Patent number: 10434191
    Abstract: The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: October 8, 2019
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Tashfeen Walton, Mark Bradley, Kev Dhaliwal, Nikolaos Avlonitis, Chris Haslett, Neil McDonald, Manuelle Debunne
  • Radiopharmaceutical solutions with advantageous properties
    Patent number: 10434198
    Abstract: The present invention relates to radiopharmaceutical compositions comprising the mother nuclide 224Ra, its daughter nuclide 212Pb, and a complexing agent that complexes with the daughter nuclide. The use of targeted chelate scavengers for 224Ra daughter nuclide opens up the possibility for using 224Ra based solutions for medial treatments.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: October 8, 2019
    Assignee: Sciencons AS
    Inventor: Roy Hartvig Larsen