Abstract: A flat optogenetic cuff interface (FOCI) is configured for functional optical stimulation of axons in a single fascicle of a peripheral nerve bundle in which the axons have been genetically modified to express light sensitive proteins for excitation or inhibition of the nerves. The FOCI is configured to gradually reshape the single fascicle to a final height between 0.2 mm and 0.5 mm by reorganizing the individual axons within the fascicle without reshaping (and damaging) the individual axons. The FOCI facilitates stimulation of axons over the entire cross-section of the reshaped fascicle within the power limitations for pulsed laser energy. An electrical interface may be included to sense nerve activity of either the stimulated axons to provide closed-loop feedback to control the optical sources or stimulated axons of a different modality to record the response.

Abstract: A surgical instrument is provided that includes a first input mechanism having axial slots formed in a periphery and a second input mechanism having helical slots formed in a surface. The instrument also includes an insert having pins extending from a surface thereof, the insert coupled to the second input mechanism such that the one or more pins extend into the helical slots, and a surgical device coupled to an end. The surgical device is moved in a first degree of freedom in response to a mechanical driving force applied to both the first input mechanism and the second input mechanism, respectively, and the surgical device is moved in a second degree of freedom in response to a mechanical driving force applied to the second input mechanism while the first input mechanism is held stationary.

Abstract: The present invention relates to a self monitoring device for attachment to the body, which incorporates real-time and correlated measurement of body movement and physiological analytes of metabolism (e.g. glucose) that can be modulated by physical activity. The system enables real time and personalized modulation of the selected physiological analyte(s) through appropriately selected cued activities and other evidence based clinical guidance dependent on previous and current analyte levels correlated with previous and current patterns of movement. The system also allows for personalization of the outputs with regular calibration to the user.

Abstract: Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

Abstract: A method for preparing an endothelial corneal graft is provided. The method comprises: providing a donor cornea; irradiating the donor cornea from an endothelial side thereof with laser radiation to cause a photodisruption in tissue of the donor cornea at a focal point of the radiation; and moving the focal point of the radiation to form an endothelial graft in the donor cornea. By irradiating the donor cornea from the endothelial side thereof, instead of the epithelial side, to cut the endothelial graft, optical inhomogeneities which may develop after death in stromal tissue of the donor cornea leave the laser cutting process substantially unaffected.

Abstract: The radiant energy bandage system is disclosed including a plurality of therapeutic lamps and a controller for operating the lamps. Batteries power the lamps and are secured to a flexible fabric layer supporting the lamps and the controller. A foam and reflective layer includes a spacer foam and radiant energy reflector. A plurality of spacer windows are aligned with the lamps for communicating lamp radiation therethrough. A sheer mesh fabric layer is supposed to cover the foam and reflective layer.

Abstract: Configurations are described for conducting ophthalmic procedures to address cataract-related clinical challenges. In one embodiment, a one-piece patient contact interface may be utilized to couple a diagnostic and/or interventional system to a cornea of a patient; in another embodiment, a two-part configuration may be utilized; in another embodiment, a liquid interface two-part embodiment may be utilized.

Abstract: Apparatus to treat an eye comprises an annular retention structure to couple to an anterior surface of the eye. The retention structure is coupled to a suction line to couple the retention structure to the eye with suction. A coupling sensor is coupled to the retention structure or the suction line to determine coupling of the retention structure to the eye. A fluid collecting container can be coupled to the retention structure to receive and collect liquid or viscous material from the retention structure. A fluid stop comprising a porous structure can be coupled to an outlet of the fluid collecting container to inhibit passage of the liquid or viscous material when the container has received an amount of the liquid or viscous material. The coupling sensor can be coupled upstream of the porous structure to provide a rapid measurement of the coupling of the retention structure to the eye.

Abstract: Disclosed herein are devices and methods of percutaneously treating an ulcerated wound using ultrasonic energy. Some methods include delivering ultrasonic energy to a target tissue located at a position subcutaneous to the ulcerated wound. In some methods, the ultrasonic energy is delivered using an ultrasonic energy delivery device.

Abstract: A surgical instrument is provided that includes a first input mechanism having axial slots formed in a periphery and a second input mechanism having helical slots formed in a surface. The instrument also includes an insert having pins extending from a surface thereof, the insert coupled to the second input mechanism such that the one or more pins extend into the helical slots, and a surgical device coupled to an end. The surgical device is moved in a first degree of freedom in response to a mechanical driving force applied to both the first input mechanism and the second input mechanism, respectively, and the surgical device is moved in a second degree of freedom in response to a mechanical driving force applied to the second input mechanism while the first input mechanism is held stationary.

Abstract: The object of the invention is a laser device for eye surgery used by ophthalmologists in the treatment with capsulotomy and iriditomy, and a device for selective laser trabeculoplasty. The essence of the ophthalmic laser combined device of the invention lies in that it has one single laser with one optical axis for both wavelengths; the basic wavelength of 1064 nm and the frequency doubled wavelength of 532 nm. Switching between both wavelengths is carried out by a polarization orientation switch. Frequency doubling is inactive at the wavelength of 1064 nm and it is active for the wavelength of 532 nm. At the wavelength of 532 nm additional optical elements for attenuating and collimating the laser pulse are switched on.

Abstract: A method and apparatus for performing ophthalmic laser surgery using a pulsed laser beam is provided. The method includes establishing an initial cutting pattern comprising a plurality of original photodisruption points, establishing an enhanced cutting pattern comprising a plurality of enhanced photodisruption points selected to decrease potential adverse effects due to patient movement and having increased density over a fixed area as compared with the plurality of original photodisruption points, and performing an ocular surgical procedure according to the enhanced cutting pattern. Enhanced cutting patterns may include circular cuts around the periphery of a capsule, vertical side cuts for lens fragmentation, raster lamellar cuts, and grid lamellar cuts. Each photodisruption point in the initial cutting pattern and the enhanced cutting pattern comprises a laser target point.

Abstract: The described physiology sensor is worn on a single finger to capture one or more different physiological signals and has a sensor body including first and second raised mounds, protruding from its surface and being longitudinally spaced-apart such as to define a transverse air gap therebetween. The mounds each retain electrodes which abut palmar surfaces of the single finger. The sensor also has one or more physiological sensing devices housed within the body, including a skin conductance sensing device. The sensor can also have at least one of a temperature sensing device, and a photoplethysmography sensing device. A processor is housed within the body and communicates with the electrodes and the sensing devices to apply an electrical excitation thereto, and to process the physiological measurements.

Abstract: A kit and/or method for use during surgery is configured to decrease the risk of accidental retention of foreign objects, such as surgical items or medical devices, used in surgery inside of a patient after the surgery is completed. Specifically, illustrative kits may include, but not be limited to, a combination of one or more foreign objects, an anchoring member attached to a point outside of the patient or surgical field, and at least one or more connection members connecting the foreign objects to the anchoring member. Illustrative methods may include, but not be limited to, anchoring one or more foreign object by one or more connection members, wherein a first end of each connection member is attached to the foreign object, and a second end of each connection member is attached to a junction member; attaching the junction member to an anchoring member; and attaching the anchoring member to a structure that is outside the patient or surgical field.

Abstract: A kit and/or method for use during surgery is configured to decrease the risk of accidental retention of foreign objects, such as surgical items or medical devices, used in surgery inside of a patient after the surgery is completed. Specifically, illustrative kits may include, but not be limited to, a combination of one or more foreign objects, an anchoring member attached to a point outside of the patient or surgical field, and at least one or more connection members connecting the foreign objects to the anchoring member. Illustrative methods may include, but not be limited to, anchoring one or more foreign object by one or more connection members, wherein a first end of each connection member is attached to the foreign object, and a second end of each connection member is attached to a junction member; attaching the junction member to an anchoring member; and attaching the anchoring member to a structure that is outside the patient or surgical field.

Abstract: A surgical laser system includes a laser engine, configured to generate a laser beam of laser pulses; a proximal optics and a distal optics, together configured to direct the laser beam to a target region, and to scan the laser beam in the target region through a scanning-point sequence; and an aberration sensor, configured to sense aberration by an aberration layer; a compensation controller, coupled to the aberration sensor, configured to generate compensation-point-dependent phase compensation control signals based on the sensed aberration; and a spatial phase compensator, positioned between the proximal optics and the distal optics, at a conjugate aberration surface, conjugate to the aberration layer, and coupled to the compensation controller, configured to receive the compensation-point-dependent phase compensation control signals, and to alter a phase of the laser beam in a compensation-point-dependent manner to compensate the sensed aberration.

Abstract: A device for resecting undesired tissue from an inner wall of a body cavity, the device having a tip section in a shape of a cylinder's sector, the tip section comprising: a plurality of optical fibers located along an inner surface of the tip section and configured to transmit laser radiation to the undesired tissue; and a cutter having a shape of a cylinder's sector located inwardly or outwardly to the plurality of optical fibers, wherein said cutter is configured to cut through the undesired tissue and thereby detach at least a part of the undesired tissue from the inner wall of the body cavity.

Abstract: A liquid-containing heat filter for use with a high-intensity light, said liquid-containing heat filter comprising a substantially hollow reservoir for receiving heat-filtering liquid therein, the reservoir comprising a first optically transparent member, a second optically transparent member, and a peripheral frame for receiving and retaining said first optically transparent member and said second optically transparent member, heat-filtering liquid disposed in said substantially hollow reservoir, and a first resiliently deformable member interposed in trapped relation between the first optically transparent member and a first portion of said peripheral frame, wherein, in use, when the heat-filtering liquid in the reservoir raises in temperature due to the heating effect of the high-intensity light, the first resiliently deformable member is compressed to thereby allow the outward movement of the first optically transparent member due to expansion of the heat-filtering liquid.

Abstract: The device intended for the stimulation of the brain by laser circularly or elliptically polarized light consists of the main unit (1) equipped in the front part with control buttons (3), and a display (2) from which at least one laser diode (16, 17, 18, 19) is supplied. At least one nasal applicator (8, 9, 10, 11) or nasal applicators (38, 39) suitably equipped in the rear part with laser diodes (40, 41) can be connected to the upper part of the main unit (1). The main unit (1) is supplied in its lower part through a connector (33), and the programmable control unit (51) with built-in battery (56) and autonomous processor (57) is an integral part of the device.

Abstract: A catheter for debulking of an undesired deposit from an inner surface of at least one of a blood vessel wall and a stent located in a blood vessel, the catheter having a tip section comprising: circumferentially-directed laser optics; and a circular-action cutter, wherein said circumferentially-directed laser optics is configured to transmit laser radiation for modifying an area of the undesired deposit thereby preparing said area for penetration of said cutter, wherein said cutter is configured to cut through said modified area and thereby debulk at least a part of the undesired deposit. In addition, a catheter for pacemaker and ICD (Implantable Cardioverter Defibrillator) lead extraction is disclosed.