Abstract: An ethyl 2-[9-(2-hydroxyquinolin-3-yl)-1,8-dioxo-3,4,9,10-tetrahydroacridine-10-yl]-acetate compound, its synthesis, and its use as an antimicrobial agent.

Abstract: A double-structured stick cosmetic includes a solid-form outer layer containing a first oil composition, and an inner core containing a second oil composition, in which the first oil composition contains (A) an alkyl-modified silicone having an alkyl group having 16 to 50 carbon atoms and (B) a wax in a solid-form at 25° C. other than (A). The component (A) may have a melting point of 25° C. or higher and 50° C. or lower. A mass ratio [(A)/(B)] of the component (A) to the component (B) contained in the first oil composition may be 0.2 or larger and 1.5 or smaller.

Abstract: An 4,5-bis(4-methoxyphenyl)-1-hexyl-2-(4-nitrophenyl)-1H-imidazole compound, its synthesis, and its use as an antimicrobial agent.

Abstract: An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a membrane polymer matrix within which the macromolecular drug compound is optionally dispersed. The concentration of the macromolecular drug compound in the core is greater than the concentration of the macromolecular drug compound in the membrane layer.

Abstract: Disclosed are an oil-dispersed composition and a cosmetic for lip care manufactured using the same. The oil-dispersed composition includes a water-soluble raw material, an ester oil including a glyceryl group and/or an isostearyl group, a paste, and a thickener, wherein the paste and thickener are included in an amount of greater than or equal to about 30 wt % based on the total amount of the oil-dispersed composition.

Abstract: Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.

Abstract: The invention relates to a wax-free water-in-oil emulsion comprising an amide of amino acid and of fatty acid, and a polymer bearing alkyl chains comprising 10 to 30 carbon atoms. This emulsion is intended for skin or lip care or makeup.

Abstract: An oil-in-water type sunscreen cosmetic containing the following component (A) and the following component (B): (A) 1% by mass or more and 40% by mass or less of emulsion particles containing an oil soluble ultraviolet ray absorbent (a1), having an average particle diameter of more than 6 ?m and 300 ?m or less, and (B) 0.3% by mass or more and 2.5% by mass or less of particles containing an oil soluble ultraviolet ray absorbent (b3) encompassed by an ionic surfactant (b1) and a hydrophobic amphiphilic substance (b2), having a content of a solid oil agent of 2.5% by mass or less based on the total amount of the particles, having an average particle diameter of 6 ?m or less.

Abstract: A 9-(2-hydroxyphenyl)-10-[3-(dimethylamino)propyl]-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione compound, its synthesis, and its use as an antimicrobial agent.

Abstract: Ready-to-use (RTU) potassium phosphates solutions for phosphorus replacement therapy are presented that include potassium phosphate and sodium chloride at a fixed volume with 1.5 to 15 mmol/100 mL phosphorus, no more than 22 mEq/100 mL potassium and less than 50 mcg/L aluminum.

Abstract: Extended release pyridostigmine dosage forms, suitable for maintaining stable plasma concentrations with reduced or minimized initial burst release/dose dumping of pyridostigmine, are provided. The dosage forms include matrix tablets, gastroretentive tablets, and pellets, the latter being suitable for dosing in capsules, tablets, and sachets, as well as for sprinkling on foodstuffs. The disclosure also provides methods for improving patient compliance by administering once-a-day extended release pyridostigmine bromide dosage forms that provide a superior controlled drug release.

Abstract: A 2-(benzo[d]oxazol-2-yl)-N?-(picolinoyloxy)acetimidamide compound, its synthesis, and its use as an antimicrobial agent.

Abstract: An application of a combination or composition of Radix et Rhizoma Notoginseng and aspirin in the preparation of a drug for preventing and treating cardiovascular and cerebrovascular diseases, the combination or composition being as follows: the dose range of Radix et Rhizoma Notoginseng is 25-500 mg/d, and the dose range of aspirin is 20-700 mg/d. The Radix et Rhizoma Notoginseng comprises commercially available products, Radix et Rhizoma Notoginseng, an extract prepared from Radix et Rhizoma Notoginseng, an active ingredient of Radix et Rhizoma Notoginseng and a preparation of Radix et Rhizoma Notoginseng, and so on. Radix et Rhizoma Notoginseng and aspirin have a synergistic effect, while reducing gastric mucosal damage caused by aspirin.

Abstract: The present invention relates to a tablet comprising Afatinib or a pharmaceutically acceptable salt thereof, wherein the tablet is obtained by direct compression. The present invention further relates to a process for manufacturing a tablet of the invention as well as the use of the tablet of the invention.

Abstract: Gel compositions including at least one copolymer of vinylpyrrolidone and acrylic acid, at least one film forming agent, and at least one coloring agent, and methods of applying such compositions to keratinous materials, are provided.

Abstract: The invention relates to a method for lubricating a component consisting of a hydrophilic compound crosslinked by means of a water-soluble transition metal chelate.

Abstract: The present application provides stable ready-to-use injectable formulations of melphalan, methods for preparing storage-stable, ready-to-use injectable formulations that include melphalan, which are easy to administer without need of any reconstitution step and has a desirable solubility, stability, and safety profile. In other embodiments, provided are storage-stable, ready-to-use, injectable liquid parenteral formulations that include melphalan and other pharmaceutically acceptable excipients.

Abstract: A versatile drug delivery system comprised of plant-based nanocellulose can be used for providing high loading and extended release for virtually any drug. This system is made from nanocrystalline cellulose chemically cross-linked to form a hydrogel. This versatile hydrogel-based drug delivery system can be functionalized to support extended release of oral dosing, relieving patient burden and increasing quality of life.

Abstract: Compositions and methods for nutraceutical compositions and methods for dietary alleviation of polycystic ovary syndrome (PCOS). Compositions may include at least one anti-hyperandrogenism ingredient. Compositions may include at least one insulin-sensitivity modulating ingredient. The anti-hyperandrogenism ingredient may include inositol. The anti-hyperandrogenism ingredient may include monacolin K (red yeast). The insulin-sensitivity modulating ingredient may include inositol. The insulin-sensitivity modulating ingredient may include curcumin. The methods may include oral administration of the compositions. The methods may include physician monitoring of symptoms during use of the compositions. Case studies demonstrate positive benefits of application of the compositions and methods in alleviation of PCOS. Demonstrated benefits include conception after lengthy infertility prior to application of the compositions and methods.

Abstract: The present disclosure relates to compositions and methods of increasing magnesium bioavailability and absorption.