Patents Examined by Daniel Sullivan
  • Enhancement of urogenital function
    Patent number: 8513306
    Abstract: A method of treating nocturia in a human individual includes administering dosages of creatine to the individual; and reducing the dosages of creatine to the individual responsive to an increase in difficulty of the individual to initiate urination. Another example method includes reducing the dosages of creatine to the individual responsive to an increase in nocturnal urination frequency of the individual. A dosing system includes doses of creatine for treating nocturia in a human individual and is configured for reduced doses for administration in response to an increase in one or more nocturia symptoms. Various other methods as well as compositions, systems, etc., are also disclosed.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: August 20, 2013
    Inventor: Robert W. Hander
  • Injectables in foam, new pharmaceutical applications
    Patent number: 8512680
    Abstract: The placing of a drug that is suitable for parenteral administration on bubbles formed with sterile gases produces an exponential increase in its active surface area with a decrease in the diameter of the bubble, modifies the kinetics of its distribution and, thanks to its micronization, increases its therapeutic effect. Furthermore, the echogenicity of the bubbles allows us to follow them on ultrasound after their injection, so that we can visualise the medicament and, thanks to its steerability, can direct it to the selected site or prevent it from reaching undesired areas. This pharmaceutical form is of interest in the treatment of diseases that require a greater local action of the injected drugs than can be achieved with the pharmaceutical forms in current use.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: August 20, 2013
    Assignee: BTG International Ltd.
    Inventor: María Antonia García-Olmedo Dominguez
  • Sustained release intraocular implants and methods for treating ocular vasculopathies
    Patent number: 8506986
    Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: August 13, 2013
    Assignee: Allergan, Inc.
    Inventors: Glenn T Huang, Brittany Jackson, James A. Burke, Ton Lin, Patrick M. Hughes, Larry A. Wheeler, Rosy Sheng Donn
  • Hydrogel composition and methods for making the same
    Patent number: 8507002
    Abstract: The invention provides a hydrogel composition comprising water and a hydrophilic polymer, wherein the hydrogel composition has (a) an ultimate tensile strength of about 10 kPa or more, (b) a compressive strength of about 70 kPa or more, or (c) an ultimate tensile strength of about 10 kPa or more and a compressive strength of about 70 kPa or more. The invention further provides methods for producing a hydrogel composition.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: August 13, 2013
    Assignee: DePuy Products, Inc.
    Inventors: Richard S. King, George Lawrence Grobe, III
  • Use of sodium selenosulfate for supplementing selenium and enhancing the therapeutic efficacy of chemotherapy agents, and a rapid process for preparing sodium selenosulfate
    Patent number: 8480995
    Abstract: The present invention relates to a use of sodium selenosulfate for supplementing selenium and enhancing the therapeutic efficacy of chemotherapy agents for cancers, and a rapid process for preparing sodium selenosulfate comprising: mixing sodium selenite, the reducing agent and sodium sulfite in a certain proportion to form sodium selenosulfate quickly.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: July 9, 2013
    Assignee: University of Science and Technology of China
    Inventor: Jinsong Zhang
  • Antiperspirant emulsion products and processes for making antiperspirant emulsion products
    Patent number: 8481012
    Abstract: Antiperspirant emulsion products and processes for forming antiperspirant emulsion products are provided. One process for making an antiperspirant emulsion product comprises the steps of heating and mixing water and an active antiperspirant compound to a first temperature to form a water phase. A hydrophobic carrier, a structurant, and cetyl PEG/PPG-10/1 dimethicone are heated and mixed to a second temperature that is greater than the first temperature to melt the structurant and form an oil phase. The oil phase is cooled and mixed to a third temperature. The water phase is gradually added to the oil phase to form an antiperspirant emulsion so that the water phase is present in an amount of from about 54 to about 89 wt. % and the oil phase is present in an amount of from about 11 to about 46 wt. % of the antiperspirant emulsion.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: July 9, 2013
    Assignee: The Dial Corporation
    Inventors: Berea A. R. Williams, Thomas Doering
  • Immediate release pharmaceutical formulation of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
    Patent number: 8475842
    Abstract: The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1 -carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: July 2, 2013
    Assignee: Astrazeneca AB
    Inventors: Michael Karl Bechtold, Claudia Bettina Packhaeuser, Katja Maren Fastnacht, Bernd Harald Liepold, Benedikt Steitz, Julie Kay Cahill, Kieran James Lennon
  • Local topical administration formulations containing indoxacarb
    Patent number: 8475818
    Abstract: The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: July 2, 2013
    Assignee: E. I. de Pont de Nemours and Company
    Inventors: Frank Guerino, Keith Alan Freehauf, Roger Mervyn Sargent, Peter Andrew O'Neil, Robert D. Simmons, Chen-Chao Wang
  • Injectable cross-linked polymeric preparations and uses thereof
    Patent number: 8461132
    Abstract: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic composition can be effectively administered into a damaged body tissue via injection or catheterization, thereby treating the damaged body tissue.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: June 11, 2013
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Smadar Cohen, Jonathan Leor
  • Reconstitutable microsphere compositions useful as ultrasonic contrast agents
    Patent number: 8460637
    Abstract: Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: June 11, 2013
    Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: Thomas B. Ottoboni, Robert E. Short
  • Fungicidal active substance combinations containing trifloxystrobin
    Patent number: 8461349
    Abstract: What are described are novel active compound combinations comprising a known oxime ether derivative (trifloxystrobin) and imidacloprid, which combinations are highly suitable for controlling phytopathogenic fungi and insects.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: June 11, 2013
    Assignee: Bayer CropScience AG
    Inventors: Ulrike Wachendorff-Neumann, Astrid Mauler-Machnik, Hirohisa Ohtake, Angelika Lubos-Erdelen
  • O/W-emulsifiers, O/W-emulsions and methods of manufacture thereof
    Patent number: 8454941
    Abstract: O/W-emulsifiers are described, comprising: (a) 30-50% by weight of hardened palm oil glycerides; (b) 15-35% by weight of potassium cetyl phosphates; (c) 20-30% by weight of cetyl alcohol, and (d) 5-15% by weight of potassium phosphate, in each case with respect to the total mass of the emulsifier. Further described are corresponding O/W-emulsions, comprising an aqueous phase, an oil phase dispersed in the aqueous phase and between 0.25 and 15% by weight of the abovementioned O/W-emulsifier. Finally, also described are methods for manufacturing such an O/W-emulsion.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: June 4, 2013
    Assignee: Symrise AG
    Inventors: Rolf Ohrmann, Martina Issleib, Edgar Endlein, Bernd Schröder
  • Cosmetic oil mousse composition
    Patent number: 8454942
    Abstract: An anhydrous oil foam composition containing: (a) at least one liquid oil; (b) at least one surfactant chosen from polyglyceryl-2 laurate; (c) at least one UV filter; and (d) a propellant, wherein the composition is waterless and is capable of imparting UV protection onto a target keratinous substrate.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: June 4, 2013
    Assignee: L'Oreal
    Inventors: Takehiko Kasai, Anthony Potin, Philippe Touzan, Paula Cziryak, Ana Kljuic
  • Injectable cross-linked polymeric preparations and uses thereof
    Patent number: 8455463
    Abstract: A therapeutic composition for treatment of a body tissue which includes an aqueous solution of a cross-linked polymer being capable of: (i) maintaining a liquid state in storage at room temperature for at least 24 hours; and (ii) assuming a gel state following deposition within the body tissue. The therapeutic composition can be effectively administered into a damaged body tissue via injection or catheterization, thereby treating the damaged body tissue.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: June 4, 2013
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Smadar Cohen, Jonathan Leor
  • Artificial nail composition having improved adhesion property
    Patent number: 8449869
    Abstract: An object of the present invention is to provide an artificial nail composition which can improve adhesion between a natural nail and an artificial nail, and also can suppress exfoliation or detachment. The artificial nail composition comprises: (a) a compound having at least one radical polymerizable unsaturated double bond in the molecule, (b) an acidic phosphorus compound having at least one radical polymerizable unsaturated double bond in the molecule, and (c) a radical polymerization initiator.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: May 28, 2013
    Assignee: Kabushiki Kaisha Shofu
    Inventors: Hisaki Tanaka, Mikito Deguchi
  • Epilatory strip
    Patent number: 8444707
    Abstract: A preformed epilatory strip comprises a matrix material that includes a mixture of a major amount—at least 60 wt %—of a sugar-based material and a minor amount—1 to 30 wt %—of a rosinous material. Optionally a particulate material, for example fumed silica, is present.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: May 21, 2013
    Assignee: Reckitt Benckiser (UK) Limited
    Inventors: David Acher, Frederic De La Torre, Marielle De La Torre, Candice Monge
  • Epilatory compositions
    Patent number: 8444708
    Abstract: An epilatory composition of the adhesive type comprises a gel-like matrix material, for example of a rosin-based or sugar-based material, together with 0.1-5 wt % of a branched polyalkene, for example polyisobutene. The resulting compositions offer skin care benefits while maintaining excellent viscoelastic and adhesive properties.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: May 21, 2013
    Assignee: Reckitt Benckiser (UK) Limited
    Inventors: David Acher, Frederic De La Torre
  • Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors
    Patent number: 8435544
    Abstract: The embodiments disclosed herein relate to ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors, and more particularly to methods for treating an ocular disease and/or condition using the disclosed compositions. According to aspects illustrated herein, there is provided a pharmaceutical composition that includes a calcineurin inhibitor or an mTOR inhibitor; a first surfactant with an HLB index greater than about 10; and a second surfactant with an HLB index of greater than about 13, wherein an absolute difference between the HLB index of the first surfactant and the HLB index of the second surfactant is greater than about 3, and wherein the composition forms mixed micelles.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: May 7, 2013
    Assignee: Lux Biosciences, Inc.
    Inventors: Ashim K. Mitra, Poonam R. Velagaleti, Subramanian Natesan
  • Transdermally absorbable preparation
    Patent number: 8431152
    Abstract: A transdermally absorbable preparation that even when a drug with poor solubility in a base is added in high concentration, is stable over time and can suppress crystallization of the drug, excelling in transdermal absorbability. There is provided a transdermally absorbable preparation, comprising a base and, added thereto, at least composite particles which are composed of a silicate compound and an organic acid and a drug.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: April 30, 2013
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Mitsuru Kuribayashi, Toshiro Yamaguchi
  • Animal attractant
    Patent number: 8431115
    Abstract: An animal attractant composition comprising 35 weight percent to 45 weight percent of a primary mineral mixture, 35 weight percent to 45 weight percent of a cobalt iodized salt, 15 weight percent to 25 weight percent of a trace mineral and Vitamins A, B and E and a method for forming an artificial animal lick that lasts no less than 3 months.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: April 30, 2013
    Inventor: Jeffrey Grimolfson