Patents Examined by David E Gallis
  • Production process of bifunctional epoxy monomer by selective oxidation of diolefin compound
    Patent number: 7696366
    Abstract: There is provided a novel method for producing a bifunctional epoxy monomer which comprises reacting diolefin with a hydrogen peroxide aqueous solution, in the presence of molybdenum or tungsten oxide as a catalyst to selectively epoxidize a double bound at a specific position. The bifunctional epoxy monomers provided by the present invention are substances widely used in various industrial fields such as chemical industry, as materials for resist materials (particularly solder resist materials), and intermediates of agrochemicals and medicines, and various polymers such as plasticizers, adhesives and coating resins.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: April 13, 2010
    Assignee: Showa Denko K.K.
    Inventors: Hiroshi Uchida, Yuko Sakata, Ritsuko Hirakawa, Kazuhiko Sato, Masanori Ookoshi
  • Process for the preparation of pyridylcarboxylic amides and esters
    Patent number: 7692020
    Abstract: The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and R1 have the meanings given in claim 1, which comprises the following steps: (a) heating a mixture consisting essentially of trichloromethylpyridine II, Formula (II), wherein Hal has the meaning given, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, characterized in that the trichloromethylpyridine II in a liquid form is added to the concentrated sulfuric acid at a temperature from 110° C. to 160° C.; and (b) reacting the intermediate product obtained in step (a) with an amine or alcohol III, HXR1, wherein X and R1 have the meaning given, optionally in the presence of a solvent and/or a base.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: April 6, 2010
    Assignee: BASF SE
    Inventors: Monika Brink, Marcus Knell, Jan Hendrik Wevers
  • Separation of propylene oxide from a mixture comprising propylene oxide and methanol
    Patent number: 7692031
    Abstract: A method of separating propylene oxide from a mixture (M) comprising propylene oxide and methanol, said method comprising: (i) introducing said mixture (M) into an extractive distillation column; (ii) additionally introducing an extracting solvent into said extractive distillation column; (iii) distilling propylene oxide overhead from said extractive distillation column as top stream; (iv) withdrawing a bottoms stream from said extractive distillation column; (v) compressing the top stream obtained overhead in (iii) by means of at least one compressor to give a compressed vapor.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: April 6, 2010
    Assignees: BASF Aktiengesellschaft, The Dow Chemical Company
    Inventors: Hans-Georg Goebbel, Henning Schultz, Peter Schultz, Renate Patrascu, Malte Schulz, Meinolf Weidenbach
  • Propylene oxide process
    Patent number: 7687647
    Abstract: A process for making propylene oxide from propylene is disclosed. The process comprises reacting propylene, oxygen, and hydrogen in the presence of a catalyst, a solvent, and a buffer to produce a reaction mixture comprising propylene oxide. Separation of light components from the reaction mixture gives a heavy residue comprising the buffer. The buffer is precipitated from the heavy residue by a precipitating agent.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: March 30, 2010
    Assignee: Lyondell Chemical Technology, L.P.
    Inventor: Te Chang
  • Organic salts and method for producing chiral organic compounds
    Patent number: 7683191
    Abstract: The invention relates to a method for producing chiral organic compounds by asymmetric catalysis, using ionic catalysts comprising a chiral catalyst anion. The claimed method is suitable for reactions which are carried out over cationic intermediate stages, such as iminium ions or acyl pyridinium ions. The invention enables the production of chiral compounds with high ee values, that until now could only be obtained by means of costly purification methods.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: March 23, 2010
    Assignee: Studiangesellschaft Kohle mbH
    Inventors: Benjamin List, Sonja Mayer, Martin Nolwenn, Wang Xingwang
  • 4-aminopiperidine derivatives
    Patent number: 7683079
    Abstract: The present invention relates to compounds of the formula (I) wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, non-insulin dependent diabetes mellitus and/or impaired glucose tolerance, obesity, and/or metabolic syndrome or ?-cell protection.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: March 23, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Michael Loeffler, Thomas Luebbers, Fabienne Ricklin
  • 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
    Patent number: 7683074
    Abstract: 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds and methods of treating arthritis and other conditions with the compounds are also provided.
    Type: Grant
    Filed: March 10, 2008
    Date of Patent: March 23, 2010
    Assignee: Biotie Therapies GmbH
    Inventors: Norbert Höfgen, Ute Egerland, Thomas Kronbach, Degenhard Marx, Stefan Szelenyi, Hildegard Kuss, Emmanuel Polymeropoulos
  • Spray-dried transition metal zeolite and its use
    Patent number: 7648936
    Abstract: A catalyst comprising a spray-dried transition metal zeolite and a noble metal is disclosed. The spray-dried transition metal zeolite comprises a transition metal zeolite and a binder. At least 50 wt. % of the binder is titania. The catalyst is used in a process to produce an epoxide by reacting an olefin, hydrogen, and oxygen. The catalyst is easy to filter from a slurry and produces a reduced level of hydrogenation products.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: January 19, 2010
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Edrick Morales, Guoyi Fu, Roger A. Grey, Kun Qin
  • Propylene oxide process
    Patent number: 7649102
    Abstract: A process for making propylene oxide from propylene is disclosed. Propylene, hydrogen, and oxygen are reacted in a slurry comprising a catalyst and a solvent to produce a gaseous product stream and a liquid product stream. The gaseous product stream is contacted with an absorbent to produce a gas effluent and a liquid effluent. The gas effluent is recycled to the reaction step.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: January 19, 2010
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Te Chang, Arsam Behkish, Jude T. Ruszkay, John H. Speidel, Jr.
  • Method of producing highly functionalized 1,3-diamino-propan-2-ols from solid support
    Patent number: 7649055
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethylamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: January 19, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • Reaction system
    Patent number: 7645892
    Abstract: Reaction gases such as hydrogen, oxygen and propylene are reacted in a slurry of solid catalyst in solvent, the reaction being carried out in a series of separate zones with intermediate removal of the exothermic heat of reaction by indirect heat exchange.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: January 12, 2010
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: John C. Jubin, Jr., Wilson H. Onimus
  • CCR5 antagonists as therapeutic agents
    Patent number: 7645771
    Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable derivatives thereof, useful in the treatment of prophylazis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: January 12, 2010
    Assignee: SmithKline Beecham Corp.
    Inventors: Wieslaw Mieczyslaw Kazmierski, Chrisopher Joseph Aquino, Neil Bifulco, Eric Eugene Boros, Brian Andrew Chauder, Pek Yoke Chong, Maosheng Duan, Felix Deanda, Jr., Cecilia Suarez Koble, Ed Williams McLean, Jennifer Poole Peckham, Angilique C Perkins, James Benjamin Thompson, Dana Vanderwall
  • Method for preparing prostaglandin derivative
    Patent number: 7642370
    Abstract: A method for preparing a prostaglandin derivative represented by the following general formula (I): (wherein Ph represents phenyl group, R1 represents a C1-7 alkyl group, a C1-7 alkenyl group, phenyl group, or benzyl group), which comprises the successive steps (1) to (8) described in the specification, or any one step or two or more successive steps selected from the group consisting of the steps (1) to (8). A method for efficiently, inexpensively and safely preparing prostaglandin derivatives, of which typical example is latanoprost, is provided.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: January 5, 2010
    Assignee: Daiichi Fine Chemical Co., Ltd.
    Inventors: Noriaki Murata, Atsunori Aramata
  • Processes and intermediates for preparing benzyl epoxides
    Patent number: 7638646
    Abstract: Disclosed are intermediates and processes for preparing epoxides of the formula: where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the production of pharmaceutical agents.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: December 29, 2009
    Assignee: Elan Pharmaceuticals Inc.
    Inventor: Michael R. Reeder
  • Composition, method of authenticating, methods of making authenticatable compositions, authenticatable articles made there from
    Patent number: 7635778
    Abstract: A composition comprising compound of formula I, a process for preparing the composition comprising compound of formula I, methods of authentication for an article comprising compound of formula I or compound of formula II, authentication technology for polymer based articles comprising compound of formula I or formula II, methods of facilitating such authentication and method of making articles capable of authentication.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: December 22, 2009
    Assignee: SABIC Innovative Plastics IP B.V.
    Inventors: Yogendrasinh Chauhan, Mahesh Chaudhari, Adil Dhalla, Sriramakrishna Maruvada, Shantaram Naik, Vandita Pai-Paranjape, Philippe Schottland, Ganapati Shankarling, Kiran Puthamane, Meerakani Sait
  • Stereospecific method for the preparation of dioxa-bicyclooctane compounds
    Patent number: 7635782
    Abstract: This invention relates to a new method for the stereospecific thiocarboxylation of organic compounds for the preparation of compounds according to formula (I): wherein a compound of formula (II): is reacted with a compound of formula (IIIa) or (IIIb): then treating the obtained product with a thiocarboxylic acid or a salt thereof, and subsequently carrying out a nitration reaction.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: December 22, 2009
    Assignee: Lacer, S.A.
    Inventors: Francisco Pubill Coy, Anna Modolell Saladrigas, Jose Repolles Moliner
  • Substituted heterocyclic ethers and their use in CNS disorders
    Patent number: 7632861
    Abstract: The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: December 15, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joanne J. Bronson, Andrew P. Degnan, William D. Schmitz
  • Intermediate for the preparation of paliperidone
    Patent number: 7629469
    Abstract: A new compound of formula (IV) R represents a protecting group which is removable by hydrogenation, and use thereof as an intermediate for preparing paliperidone.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: December 8, 2009
    Assignee: Scinopharm Taiwan, Ltd.
    Inventors: Tsung-Cheng Hu, Hsiao-ping Fang, Hong-Tsung Huang
  • Synthesis of himbacine analogs
    Patent number: 7626045
    Abstract: The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: December 1, 2009
    Assignee: Schering Corporation
    Inventors: Tiruvettipuram K. Thiruvengadam, Tao Wang, Jing Liao, John S. Chiu, David J. S. Tsai, Hong-Chang Lee, Wenxue Wu, Xiaoyong Fu
  • Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents
    Patent number: 7622480
    Abstract: This invention is directed to selective antagonists of H1 histamine receptors having the general formula (I); to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: November 24, 2009
    Assignee: Laboratorios Almirall S.A.
    Inventors: Silvia Fonquerna Pou, Luis Miguel Pages Santacana, Carlos Puig Duran, Jose Manuel Prieto Soto, Aranzazu Cardus Figueras