Abstract: A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. A controller may be physically connected to the monitoring system from the sterile field to allow the user to control the monitoring system.

Abstract: Systems and methods for anatomical alignment are disclosed herein. In some embodiments, the systems and methods can provide accurate and continuous intraoperative validation of anatomical alignment, e.g., of the spine, hips, pelvis, and/or shoulders. An exemplary system can include a sensor and marker arrangement for measuring coronal imbalance. Another exemplary system can include a sensor and marker arrangement for shoulder or pelvic leveling. Yet another exemplary system can include a mechanical frame for establishing a simulated ground plane and projecting a plumb line from the simulated ground plane.

Abstract: A pulse wave analyzing apparatus comprises an acquiring section (11) which acquires a pulse wave that is non-invasively measured, and an analyzer (12) which calculates data on the frequency axis by using the pulse wave, and which obtains the index value of the respiratory-induced variation based on the calculated data on the frequency axis.

Abstract: A minimally invasive system comprises an elongate instrument that includes a flexible proximal portion, a rigid distal portion, and a lumen extending from a proximal end to a distal end of the elongate instrument. The lumen defines a longitudinal axis of the elongate instrument. The flexible proximal portion is fixedly coupled to the rigid distal portion. The system further comprises a stylet slidably disposed within the elongate instrument. The stylet includes a flexible body fixedly coupled to a steerable portion and includes a sensor. The stylet is movable within the elongate instrument between a retracted condition and an extended configuration. A plurality of actuation cables extend through the stylet and terminate in the steerable portion, which comprises a bend-resistive section and a bendable section. The bendable section includes a plurality of articulable segments linked by the actuation cables and includes a plurality of joint pivots disposed between adjacent articulable segments.

Abstract: Sample collection apparatus and methods of sample collection are provided, for example saliva collection apparatus and methods of saliva collection. Said apparatus conveniently comprises a filter assembly and an interface for delivering material from the apparatus to an assay unit.

Abstract: Disclosed embodiments pertain to cardiovascular parameter (e.g. heart rate) measurements when motion is present. Biometric sensor signal measurements may be obtained based on cardiovascular parameters of a user; and motion sensor signal measurements may be obtained based on user motion. An activity type may be determined based on the motion sensor signals. For example, when non-motion related frequencies in a frequency domain representation of the biometric sensor signal are obscured by user motion, an activity type may be determined based on the motion sensor signals. Further, based on the activity type, for each cardiovascular parameter (e.g. heart rate), a corresponding likely cardiovascular parameter value (e.g. a likely heart rate) may be determined. A corresponding fundamental frequency associated with the biometric sensor signal may then be determined for each cardiovascular parameter based on the motion sensor signal measurements and the corresponding likely cardiovascular parameter value.

Abstract: A state of progression in an individual of a disease or treatment having motion symptoms is determined. A time series of accelerometer data is obtained from an accelerometer worn on an extremity of the person, over an extended period during everyday activities of the person. The accelerometer data is processed to produce a plurality of measures of kinetic state of the individual at a respective plurality of times throughout the extended period, each measure of kinetic state comprising at least one of: a measure for bradykinesia, and a measure for dyskinesia. A measure of dispersion of the measures of kinetic state is determined. An output is generated, indicating that motion symptoms are at an initial stage if the measure of dispersion is less than a threshold, or indicating that motion symptoms are at an advanced stage if the measure of dispersion is greater than the threshold.

Abstract: A device, for the pressure-supported or pressure-controlled ventilation of a patient with reduced spontaneous breathing, has a ventilator unit to supply a breathing air flow composed of cyclical ventilation strokes and a control unit generating a control signal to set a pressure and/or a volume flow of the breathing air flow. An EMG unit generates an EMG signal, which may be used as a basis for generating the control signal as a function of a breath of the patient. A unit for analyzing an EMG signal is provided, which analyzes at least one EMG signal recorded during an already concluded breath of the patient. The control unit is configured such that the ventilator unit control signal can be generated, at least at times, by taking into account the analysis of the EMG signal recorded during an already concluded breath of the patient.

Abstract: The invention provides a sensor assembly embeddable within an oral appliance comprising a sensing means; and a data processing means coupled to the sensing means for processing data obtained by the sensing means; wherein the sensing means and the data processing means are sealed within a deformable layer.

Abstract: Methods, devices, systems and kits for obtaining blood samples are provided. Devices include a cuff, a pressure source, and a timing mechanism. Devices may further include one or more of a: warming mechanism, lancing mechanism; automated sample collection device, automated sample analysis device, and communication unit. Systems include such a device, and may include sample collection, sample analysis, or communication devices. Methods include placing a cuff on a digit of a subject, inflating the cuff, and obtaining a small volume blood sample. Methods may further include warming a digit; lancing a digit; pulsing the cuff; and providing a signal indicating the end of the sample collection time period. Kits may include a device, a sample collection vessel, and may include a disposable for use in sample collection. These methods, devices, systems and kits for obtaining blood samples may be used to easily, reliably, and consistently obtain blood samples from subjects.

Abstract: A needle assembly comprising a housing, a first needle hub provided by the housing, a first hollow needle portion mounted to the first needle hub and extending from the first needle hub in a distal direction. A second needle hub is provided by the housing. A second hollow needle portion is mounted to the second needle hub and extends from the second needle hub in a proximal direction, opposite to the distal direction, wherein a hollow flashback chamber is arranged within the housing between the first needle portion and the second needle portion. The flashback chamber communicates with the inner lumen provided within the first and second hollow needle portion and is connected to the atmosphere by a passage and wherein a filter is provided within the passage, which is designed such that it is permeable for air to pour out of the flashback chamber into the atmosphere.

Abstract: A cryogenic biopsy device is configured to provide tissue samples that are partially frozen and partially non-frozen. This enables histopathology analysis of the intact non-frozen part of the tissue sample and assessment of the in-vivo biomolecular state of the tissue that is stabilized and maintained in the frozen part of the sample. The device of the present invention may be used in rigid instruments and in flexible devices, such as endoscopes, for example, and may be suitable for single use or multiple use.

Abstract: A biopsy device includes a cannula that defines a tissue chamber configured to receive a tissue sample from a patient. A pressure chamber includes a body having a distal end and a proximal end. The proximal end has an inlet coupled in fluid communication with the cannula. The body has a first recessed area proximate the proximal end, wherein the first recessed area is configured to release positive pressure within the pressure chamber. The body has a second recessed area proximate the distal end, wherein the second recessed area is configured to release negative pressure within the pressure chamber. A piston is movably received in the body and configured to move over the first recessed area to release the positive pressure and configured to move over the second recessed area to release the negative pressure.

Abstract: Provided herein are devices and methods for securing surgical guide wires. In particular, provided herein are devices for securing radiologically located guide wires prior to surgery (e.g., lumpectomy).

Abstract: A device includes a digit probe, a plurality of optical elements, a processor, and a communication module. The digit probe has an interior surface and has an exterior surface. The interior surface is configured to engage a digit and the exterior surface is configured to engage a tissue site associated with the digit. The plurality of optical elements is coupled to at least one of the interior surface and the exterior surface. The plurality of optical elements includes at least one emitter and includes at least one detector. The processor is coupled to the plurality of optical elements. The processor is configured to generate a measure of arterial oxygenation corresponding to the digit and configured to generate a measure of regional oxygenation corresponding to the tissue site. The communication module is coupled to the processor. The communication module is configured to communicate the measure of arterial oxygenation and regional oxygenation with a remote device.

Abstract: Systems and methods facilitating objective evaluations of subjects to facilitate detecting clinically relevant changes in balance are provided. The system includes a portable balance board with a sensor in each of four feet for detecting downward force. Each sensor is communicatively coupled to a circuit board with a wired or wireless communication capability. A subject stands on the balance board and each sensor sends a signal to the circuit board, which communicates the four signals to a companion device that uses the signals to calculate the center of pressure (“COP”) of the subject over time. The subject can perform the BESS test and the resulting COP data is used to calculate a field path length for the subject. The field path length is compared to a previously determined baseline path length for the subject to detect any clinically relevant change in balance of the subject.

Abstract: A computer-implemented method for estimating an age of a target individual includes obtaining information of eye movement of the target individual, analyzing the information of the eye movement to extract a feature of the eye movement, and estimating the age of the target individual using the feature of the eye movement.

Abstract: Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.

Abstract: A biological information measurement apparatus includes a biological sensor and an insertion portion, and the biological sensor is disposed at a position opposite the concha when the insertion portion is inserted in the external ear canal.

Abstract: A method includes obtaining test data for a joint, the test data being indicative of motion of the joint during joint testing implemented by a robotic testing apparatus applied to the joint to impart force oriented in a first degree of freedom for the joint, generating first data indicative of movement of the joint in the first degree of freedom based on the test data, generating second data indicative of concomitant movement of the joint in a second degree of freedom for the joint based on the test data, the concomitant movement arising from the imparted force, and determining a condition of the joint based on an analysis of the first data and the second data.