Abstract: Disclosed are methods and preparations useful for reducing fat at a targeted area(s) on a human. The preparations comprise as an active ingredient an adipolysis enhancing (i.e., fat-melting) amount of an active ingredient, paeoniflorin (PF). The preparations may be provided as an injectable preparation or as a topically applied preparation, such as in the form of a crème or lotion. In topical preparations, the active ingredient paeoniflorin may be contained within nanospheres, such as albumin nanospheres. The PF-containing preparations may also include a permeant, such as azone. The method may be accompanied by the application of ultrasound to the area being treated prior to, during or after, or prior to, during, and after application of the paeoniflorin preparation to an area of the body in which fat reduction is desired.
Abstract: Described herein are methods and compositions for increasing dermal concentrations of glycosaminoglycans (GAG), including hyaluronic acid. Exemplary methods involve a one-step protocol and a three-step protocol. Either method can be used over a 90-day treatment period.
Type:
Grant
Filed:
December 8, 2016
Date of Patent:
February 20, 2018
Assignee:
SHAMROC, INC.
Inventors:
Mark W. Trumbore, Drake D. Stimson, Ronald M. Gurge
Abstract: The present invention relates to a composition containing an extract from the Polygonum minus for cognition and cosmetic purposes. The extract of Polygonum minus includes quercetin-3-glucuronide and quercitrin. Extract of Polygonum minus is provided in an amount effective to reduce oxidative damage. A process for isolation of an active extract from Polygonum minus includes the steps of a) subjecting the Polygonum minus including aerial parts of the plant to solvent extraction preferably with a material solvent ratio of 1:10-20 by percolation at a temperature range of 70-105° C. preferably 80° C. to obtain the extract; and b) filtering the extract obtained from step (a) followed by concentration and drying involving freeze drying, spray drying or vacuum belt drying to obtain therefrom the dry extract powder.
Type:
Grant
Filed:
February 26, 2013
Date of Patent:
January 30, 2018
Assignee:
BIOTROPICS MALAYSIA BERHAD
Inventors:
Annie George V. K. George, Kar Ming Yee
Abstract: Pharmaceutical compositions containing an extract of Houttuynia cordata (THUNB) as an active ingredient for preventing and treating dementia, Parkinson's disease, or epilepsy and methods for using the same. Since the extract of Houttuynia cordata or the mixture of the extract of Houttuynia cordata and the extract of Ampelopsis japonica Makino has a cell protection effect and/or a cognition function improved effect in various models including an Amyloid-? induced dementia model, a scopolamine induced dementia model, a 6-hydroxydopamine (6-OHDA) induced Parkinson's disease model, and a Kainic acid induced epilepsy model, the extract of Houttuynia cordata or the mixture of the extract of Houttuynia cordata and the extract of Ampelopsis japonica Makino may be used as the pharmaceutical composition for preventing and treating dementia, Parkinson's disease, or epilepsy and in health foods for preventing and treating dementia, Parkinson's disease, or epilepsy.
Type:
Grant
Filed:
April 10, 2014
Date of Patent:
January 9, 2018
Assignee:
UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
Inventors:
Myung Sook Oh, Hyo Geun Kim, Hanbyeol Park
Abstract: The present invention is based on the surprising antiseptic nature of chlorhexidine when combined with essential oils. It has been found that chlorhexidine, combined with an essential oil, is surprisingly effective at penetrating the skin surface and providing an antiseptic effect within the skin. It has also been found that a combination of chlorhexidine and eucalyptus oil is surprisingly effective as an antimicrobial against Staphylococcus epidermidis.
Abstract: Provided herein are cream formulations comprising sandalwood oil, an antioxidant and a phosphate buffer. Also provided are methods of making and using the formulations. Further provided herein is a method of treating a skin disorder in a subject by administering to the subject a therapeutically effective amount of a cream formulation comprising sandalwood oil, an antioxidant and a phosphate buffer, wherein the subject has a skin disorder or is at risk of developing a skin disorder.
Type:
Grant
Filed:
March 13, 2014
Date of Patent:
January 9, 2018
Assignee:
SANTALIS HEALTHCARE CORPORATION
Inventors:
Ian Clements, Paul Castella, Corey Levenson
Abstract: A traditional Chinese medicine complex composite for significantly improving high density lipoprotein (HDL) concentration in serum, includes: a tablet which includes 30%-50% hawthorn from north China, 10%-30% radix aucklandiae, 10%-30% radix glehniae and 10%-30% ligusticum wallichii; and a powder which includes 40%-60% beef, 15%-35% bovine sinew, 15%-35% pigskin and 0.5%-2.5% Chinese-date. The tablet is prepared by decocting and boiling the raw material medicine with water, and the powder is prepared by catalytic hydrolysis with an enzyme, the pigskin in the powder can be replaced with bovine skin or donkey skin, and the bovine sinew can be replaced with bovine tendon.
Abstract: Provided is a pharmaceutical composition useful for prevention and/or treatment of diseases caused by bacteria, wherein the pharmaceutical composition comprising a honeysuckle extract containing iridoid compounds and an antibiotic. Also provided is a pharmaceutical kit comprising the honeysuckle extract containing the iridoid compounds and the antibiotics which are separately placed. The honeysuckle extract is used in combination with the antibiotics, the responsiveness of multi-drug resistant bacteria to antibiotics is improved, a clinical application prospect is presented, especially the current status of the refractory bacterial infection diseases caused by the pathogenic bacteria resistant to the antibiotics can be improved. Also provided is a use of the pharmaceutical composition and pharmaceutical kit in the preparation of drugs for prevention and/or treatment a diseases caused by bacteria.
Abstract: The invention provides a composition the prevention and treatment of cardiovascular disease, wherein said composition compounds obtained from palm oil mill effluents, in particular from vegetative liquor from the milling of palm oil fruit.
Type:
Grant
Filed:
April 20, 2015
Date of Patent:
December 12, 2017
Assignee:
MALAYSIAN PALM OIL BOARD
Inventors:
Hjh Che Anishas HJ. Che Idris, Nagendran Balasundram, Ravigadevi Sambanthamurthi, Yew Ai Tan, Kalyana Sundram P. Manickam, Mohd Basri Wahid
Abstract: Provided herein are compositions, formulations, kits, and methods for improving or modifying cognitive performance in an individual having normal-age related cognitive decline. The composition can include an amount of a blueberry extract, L-carnosine, a green tea extract, vitamin D3, and a grape extract. The composition can be included in a pharmaceutical formulation and be administered to a subject having normal-age related cognitive decline according to a dosing regimen.
Type:
Grant
Filed:
May 30, 2014
Date of Patent:
November 28, 2017
Assignees:
University of South Florida, Natura Therapeutics, Inc., The Unites States of America as Represented by the Department of Veterans Affairs Office of General Counsel—PSG IV (024)
Inventors:
Paula C. Bickford, Cyndy Davis Sanberg, Jun Tan, Roland Douglas Shytle, Paul D. Sanberg
Abstract: Compositions and methods for maintaining healthy skin and alleviating skin conditions such as redness, inflammation, irritation and skin aging, as well as for maintaining healthy scalp and hair are disclosed. The oral compositions disclosed comprise antioxidants including lycopene, gallic acid and ascorbic acid. Preferably lycopene has been water-extracted, more preferably under acid conditions. In the method of treatment aspect of the invention, an oral composition containing antioxidant(s) is administered to a person concurrently with a topical treatment for said skin conditions. Preferred topical compositions comprise cyclohexane polyols, such as cyclohexanediol or cyclohexanetriol.
Abstract: Described herein are methods and compositions for increasing dermal concentrations of glycosaminoglycans (GAG), including hyaluronic acid. Exemplary methods involve a one-step protocol and a three-step protocol. Either method can be used over a 90-day treatment period.
Type:
Grant
Filed:
December 12, 2013
Date of Patent:
October 31, 2017
Assignee:
SHAMROC, INC.
Inventors:
Mark W. Trumbore, Drake D. Stimson, Ronald M. Gurge
Abstract: Supplements for maintaining a healthy immune response include one or more extracts from rosemary, turmeric, green tea, ginger, holy basil, oregano, boswellia, black currant, and clove. The supplements may include an extract of thyme. The supplements may exclude anti-inflammatory drugs and certain anti-inflammatory herbs.
Type:
Grant
Filed:
March 13, 2015
Date of Patent:
October 17, 2017
Assignee:
The Procter & Gamble Company
Inventors:
Jennifer Marie Toomey, Graham Rigby, Paul Schulick
Abstract: Compositions obtained from vegetation water from olives and methods for treating patients suffering from an inflammatory skin disease with the compositions are described. Included are hydroxytyrosol rich compounds obtained from olive vegetation water.
Type:
Grant
Filed:
July 19, 2005
Date of Patent:
October 17, 2017
Assignee:
CreAgri, Inc.
Inventors:
Fujio Numano, Roberto Crea, Tokuko S. Wiedemann, Catherine M. Bitler
Abstract: The invention discloses a method of processing Zingiber zerumbet for producing a processed sample of Zingiber zerumbet, which easily releases flavonoids in a following extraction process. The method includes the steps of: soaking a raw sample of Zingiber zerumbet with a processing reagent selected from rice vinegar or yellow wine at 23-27° C. for 20-28 hours; and steaming the soaked product at 0.6-1.4 kg/cm2, 80-120° C. for 20-40 minutes.
Abstract: The present invention relates to a composition for the use in improving vascular health, including treating and preventing vascular diseases and diseases related thereto, using a botanical extract of oil palm vegetation liquor from the palm oil milling process.
Type:
Grant
Filed:
July 2, 2014
Date of Patent:
September 5, 2017
Assignee:
MALAYSIAN PALM OIL BOARD
Inventors:
Mahinda Abeywardena, Ravigadevi Sambanthamurthi, Yew Ai Tan, Kalyana Sundram P. Manickam, Mohd Basri Wahid
Abstract: The present invention provides a method for treating breast cancer in a subject, which comprises administering to said subject an effective amount of an alcohol extract of dehulled adlay seeds. Preferably, an ethyl acetate sub-fraction of the alcohol extract of dehulled adlay seeds has a better effect in treating breast cancer.
Abstract: The present invention relates to a composition including an Amomi Rotundus Fructus extract or a fraction thereof as an active ingredient, which can be used for the prevention, amelioration, or treatment of acute renal failure.
Type:
Grant
Filed:
November 6, 2013
Date of Patent:
August 22, 2017
Assignee:
KOREA INSTITUTE OF ORIENTAL MEDICINE
Inventors:
Hyun Kyoo Shin, Ju Young Jung, Hye Kyung Ha, Chang Seob Seo, Young Jung Kim
Abstract: Disclosed are compositions containing an extract of Serenoa repens, a lipophilic extract of Zingiber officinalis and a lipophilic extract of Echinacea angustifolia or Zanthoxylum bungeanum.
Abstract: A skin care composition for topical use wherein the composition comprises avocado & coconut cream oil, cucumber extract and dandelion root's extract and a method to prepare the composition comprising mixing coconut cream and avocado fruit to make a paste, followed by heating to remove moisture and then extract oil. Mixing the oil obtained with cucumber extract and dandelion extract. The composition is used as anti-aging and moisturizing composition and suitable to all skin types.