Patents Examined by Delbert R. Phillips
  • Insulin-selective somatostatin analogs
    Patent number: 4816438
    Abstract: Anglerfish somatostatin-28 has the formula: ##STR1## Anglerfish somatostation-28 is insulin-selective when administered in vivo and is useful for the treatment of insulinoma. The 14-residue C-terminal peptide may also be used.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: March 28, 1989
    Assignee: The Salk Institute for Biological Studies
    Inventors: Joachim Spiess, Bryan D. Noe
  • Method for producing hepatitis B virus proteins in yeast
    Patent number: 4816564
    Abstract: The entire hepatitis B Virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: March 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ronald W. Ellis, Arpi Hagopian, Peter J. Kniskern
  • Immunotherapeutic anti-inflammatory peptide agents
    Patent number: 4816449
    Abstract: Anti-inflammatory peptides of the formula A-B-C-D-E, useful in treating allergies, autoimmune diseases, and other disorders, and methods for using them are described.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: March 28, 1989
    Assignee: Immunetech Pharmaceuticals
    Inventor: Gary S. Hahn
  • Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
    Patent number: 4814323
    Abstract: The invention relates to a process for the treatment and the prevention of the acquired immunodeficiency syndrome (AIDS) and AIDS related complex (ARC) induced by the LAV/HTLV III virus in a patient infected with said virus, comprising administering to said patient an effective amount of a compound selected from cyclosporins.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: March 21, 1989
    Inventors: J. M. Andrieu, P. Even, Alain Venet
  • Nor-statine and nor-cyclostatine polypeptides
    Patent number: 4814342
    Abstract: Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: March 21, 1989
    Assignee: Pfizer Inc.
    Inventors: Dennis J. Hoover, Robert L. Rosati, Ronald T. Wester
  • Inducer of T-suppressor cells
    Patent number: 4814434
    Abstract: A biologically active composition extracted from thymus tissue, capable of inducing immature bone marrow cells to differentiate into competent suppressor T-cells.
    Type: Grant
    Filed: November 15, 1984
    Date of Patent: March 21, 1989
    Assignee: Ventres Laboratories, Inc.
    Inventor: Marcia F. Goldfarb
  • Synthetic peptide antigen for the detection of HIV-2 infection
    Patent number: 4812556
    Abstract: A synthetic peptide antigen corresponding to a region of the glycoprotein gp41 encoded by the env gene of HIV-2 is provided. The peptide which is immunologically reactive with HIV-2 specific antibodies is useful in assays for detection of HIV-2 infection or exposure and in compositions to elicit the production of antibodies against HIV-2 in animals including man.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: March 14, 1989
    Assignee: Virovahl
    Inventors: Anders Vahlne, Bo Svennerholm, Lars Rymo, Stig Jeansson, Peter Horal
  • Tripeptide renin inhibitors
    Patent number: 4812442
    Abstract: Enzyme tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems employing the novel tripeptides.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: March 14, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Joshua S. Boger, Ben E. Evans, Mark G. Bock
  • Flavivirus antigen
    Patent number: 4810492
    Abstract: There is disclosed an antigen comprising at least part of an amino acid sence of the antigen of a flavivirus, which part contains at least one of epitopes of the flavivirus antigen. The present antigen can be produced easily and safely at low cost by means of recombinant DNA technique. The present antigen can be used as an effective vaccine and diagnostic for Japanese encephalitis.
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: March 7, 1989
    Assignee: The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Hiroyuki Fujita, Iwao Yoshida, Mitsuo Takagi, Sadao Manabe, Konosuke Fukai
  • Antimicrobial compounds
    Patent number: 4810777
    Abstract: A new class of broad spectrum antibiotic polypeptides termed "Magainin" have been described. These peptides have a molecular weight of about 2500 or less, are highly water soluble, non-cytolyic to animal cells including red-blood cells and are amphiphilic.
    Type: Grant
    Filed: March 4, 1987
    Date of Patent: March 7, 1989
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Michael A. Zasloff
  • Polypeptides useful in vaccination against enteroviruses
    Patent number: 4810491
    Abstract: A synthetic polypeptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus, is an octapeptide coded for by codons 93-100 in the RNA sequence coded for the structural capsid protein VP1 for poliovirus type 3 Sabin strain or by equivalent codons of another enterovirus or is an antigenic equivalent of such an octapeptide, the numbers of the codons being counted from the 5'-terminus of the nucleotide sequence for the VP1 capsid protein.
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: March 7, 1989
    Assignee: National Research Development Corporation
    Inventors: Philip D. Minor, David M. A. Evans, Geoffrey C. Schild, Jeffrey W. Almond
  • Method for inducing biological coverings in wounds
    Patent number: 4810693
    Abstract: Methods are disclosed for (a) enhancing the formation of a natural biological dressing composed primarily of serum proteins; (b) enhancing the reestablishment for free, full-thickness skin grafts in warm-blooded animals; (c) enhancing the establishment of split-thickness skin grafts; and (d) increasing the rate of wound closure in warm-blooded animals. The methods utilize GHL-Cu or a derivative thereof.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: March 7, 1989
    Assignee: ProCyte Corporation
    Inventor: Loren R. Pickart
  • Intermediates for preparing 1,6-dicarba-vasopressin compounds
    Patent number: 4810778
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: March 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • Decapeptides having hypotensive action and process for their preparation
    Patent number: 4810779
    Abstract: New decapeptides having hypotensive action are disclosed, which can be defined by the formula:GLp-Leu-Trp-Pro-X-Pro-Y-Z-Pro-Pro-OH (I)wherein:X=Arg or OrnY=His or GlnZ=Ile or Valwith the following limitations:whenX=Arg:Y=HisZ=Val;whenX=Orn:Y=GlnZ=Ile;or, whenX=Orn:Y=HisZ=Valand pharmaceutically acceptable salts, amides of alkyl esters thereof.
    Type: Grant
    Filed: June 3, 1986
    Date of Patent: March 7, 1989
    Assignee: Enichem Elastomeri S.p.A.
    Inventors: Valerio Caciagli, Antonio S. Verdini, Giovanna De Luca, Giovanni Di Stazio, Vincenzo Politi
  • Immunosuppressant substances, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4810692
    Abstract: The invention provides two novel immunosuppressant cyclodepsipeptides of formula: ##STR1## in which X is chlorine or hydrogen. These compounds may be made by culturing Streptomyces sp. S-16328 (CBS 162.86). The compound in which X is chlorine may be hydrogenolysed to give the compound in which X is hydrogen.
    Type: Grant
    Filed: May 21, 1987
    Date of Patent: March 7, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Maurice Deschamps, Francois Floc'h, Gerard Jung, Rodolphe Margraff
  • Methods of preparing epitopes of tumor associated antigens
    Patent number: 4810781
    Abstract: Methods are disclosed for preparing (1) a pure, biologically active, immunogenic tumor-associated antigen by forming a soluble pool of membrane proteins from antigenic tissue and, by separating, identifying and characterizing antigenic and/or immunogenic proteins therefrom; (2) an ultrapure, biologically active TAA by further subjecting the pure TAA to isotachophoresis and/or affinity chromatography; and (3) making an epitope from purified TAA by injecting TAA into a host animal to stimulate the production by lymphocytes of antibodies specific to TAA, forming hybridomas capable of secreting monoclonal antibodies reactive with the TAA, dividing the TAA into fragments including epitopes, forming epitope-monoclonal antibody complexes, separating the complexes to recover the epitopes, and thereafter identifying and characterizing the epitopes.
    Type: Grant
    Filed: October 13, 1987
    Date of Patent: March 7, 1989
    Assignee: The George Washington University
    Inventor: Ariel C. Hollinshead
  • Stable formulations of ricin toxin a chain and of RTA-immunoconjugates and stabilizer screening methods therefor
    Patent number: 4808705
    Abstract: Highly stable pharmaceutical compositions suitable for parenteral administration to animals or humans comprising a therapeutically effective amount of an RTA-immunoconjugate dissolved in an inert carrier method comprising a stabilizer are claimed. Screening methods for selecting stabilizers effective in preventing precipitation and aggregation of such compositions are described. Preferred stabilizers includes glycerol at a concentration (v/v) of from about 25 to about 35%; dextran sulfates having molecular weights from about 0.1.times.10.sup.6 to about 2.times.10.sup.6 daltons; and human serum albumin.The invention further comprises such compositions which have been lyophilized and/or reconstituted wherein the stabilizer is non-volatile, and may further comprise a carbohydrate stabilizer.The invention further comprises stabilized RTA compositions.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: February 28, 1989
    Assignee: Cetus Corporation
    Inventor: Robert Ferris
  • Monoclonal antibodies against melanocytes
    Patent number: 4806628
    Abstract: Monoclonal antibodies were discovered which recognize differentiation antigens on melanocytes and melanoma cells at various stages of differentiation. A system of classification based on these antigens is proposed and their use in the diagnosis and treatment of melanoma is given.
    Type: Grant
    Filed: March 17, 1986
    Date of Patent: February 21, 1989
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Anthony Albino, J. Gregory Cairncross, Magdalena Eisinger, Alan N. Houghton, Lloyd Old
  • Proline-containing renin inhibitors
    Patent number: 4804743
    Abstract: This invention concerns novel renin-inhibitory peptides containing proline which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Intermediates and processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and methods of treatment are included. Also included is a method of diagnosis of renin-associated hypertension using the compounds of the invention.
    Type: Grant
    Filed: January 29, 1987
    Date of Patent: February 14, 1989
    Assignee: Warner-Lambert Copmany
    Inventors: James S. Kaltenbronn, Elizabeth A. Lunney, Ernest D. Nicolaides
  • Solubilized lignosulfonate derivatives
    Patent number: RE32895
    Abstract: Valuable new and widely used compositions of matter are comprised of products having enhanced solubility and increased dispersant and the like surfactant activity which products are resulfonated units of alkaline oxidized, hydrolyzed, partially desulfonated lignosulfonates.
    Type: Grant
    Filed: September 17, 1981
    Date of Patent: March 28, 1989
    Assignee: Reed Lignin, Inc.
    Inventors: William J. Detroit, Michael E. Sanford