Abstract: A method and system for analyzing gait asymmetry between left and right feet of individuals by measuring and comparing stance phase time and/or stance phase force between left and right feet during gait, and providing real-time sensory feedback if stance phase time/force inequality exceeds a predetermined threshold.

Abstract: A system and method are described herein for detecting a user's transition between sitting and standing postures. Transitions between sitting and standing states are reliably detected using an accelerometer attached to the user. By modeling error introduced by the accelerometer, and correcting for this error, transitions between sitting and standing states are reliably detected. A microprocessor coupled to the accelerometer converts the captured accelerometer data to approximate vertical acceleration. Vertical velocity, which includes accelerometer error, is determined from the approximate vertical acceleration. The vertical velocity is corrected, and the corrected vertical velocity used to determine vertical displacement. Transitions between sitting and standing states are determined from the vertical displacement.

Abstract: Apparatus for electrically connecting measurement apparatus to a biological subject, the apparatus including a signal delivery circuit including a current buffer having a current buffer input for receiving a signal from a signal source and a current buffer output for supplying a current to an electrode attached to the biological subject, and a voltage buffer having a voltage buffer input coupled to the current buffer output and a voltage buffer output for providing a voltage signal indicative of a voltage at the electrode, to a sensor.

Abstract: A transseptal guidewire and methods for perforating the intra-atrial septum of the heart are disclosed. The transseptal guidewire has an elongated body, an end section biased in a curved configuration to define a proximal curve, and a distal section biased in a curved configuration to define a distal curve, the distal curve being oriented in a direction generally opposite that of the proximal curve.

Abstract: Systems, methods, computer-readable media (e.g., transitory and non-transitory) and apparatus are described herein for obtaining medical diagnostic measurements that are accurate and/or consistent over time.

Abstract: A medical needle includes a needle body including a needle tip on a front end of the needle body; a shaft provided on a base end of the needle body; a housing pipe including a first tube, and a second tube; and a lock member that includes at least one engaging unit that is releasably engaged with the shaft, and at least one engagement release unit. The shaft is slidable from a first position at which the front end of the needle body protrudes from the housing pipe by a predetermined length, to a second position at which the front end of the needle body is located in the housing pipe. Engagement of the at least one engaging unit with the shaft is releasable by pressing the at least one engagement release unit inward.

Abstract: Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

Abstract: A method for verifying the position of at least two bone structures relative to each other, comprising the method steps of: recording a three-dimensional dataset which represents the bone structures; segmenting the three-dimensional dataset into segments, wherein each segment represents a bone structure and the segments exhibit a known relative position in the three-dimensional dataset; changing the virtual relative position of the segments, such that the virtual relative position of the segments matches the actual relative position of the bone structures; and verifying whether the virtual relative position of the segments matches a target position of the bone structures.

Abstract: A body fluid sampling device for use on a patient includes at least one penetrating member positioned in the cartridge and a sample port for receiving a body fluid. A channel is coupled to the sample port and the sample chamber. At least a portion of the channel is a capillary channel positioned adjacent to the sample chamber. A mesh membrane is and provides that the body fluid contacts the channel regardless of an orientation of body fluid sampling device.

Abstract: A catheter includes a distal distension balloon and circumferentially arranged motility measurement balloons proximal of the distension balloon. A manifold includes balloon ports each configured to fluidly couple to a motility measurement balloon, pressure transducer ports, and a priming port. A port selector is coupled to the manifold and movable between different positions. Each port selector position causes the manifold to establish different fluidic couplings between the respective motility balloon, pressure transducer, and priming ports. A pressure sensing device includes pressure transducers each fluidly coupled to one of the pressure transducer ports. The pressure sensing device is configured to coordinate calibration of the pressure transducers at atmospheric pressure with the port selector in a first position and motility balloon pressure measurements with the port selector in a third position.

Abstract: The present invention relates to an apparatus and a method for measuring muscular activity, in particular in relation to bruxism, and providing an electrical stimulation in response to the measured muscular activity through electrodes applied to the skin of an individual, wherein the quality of the connectivity of the electrodes to the skin is monitored and the electrical stimulation signal is changed based on said quality measurement.

Abstract: A vent plug is disclosed that includes a body having a distal end, a proximal end, and a lumen extending through the distal and proximal ends. A membrane is disposed across the lumen, the membrane being hydrophobic and air permeable. A fluid chamber is formed within the lumen distal the membrane. A distal lumen opening being shaped and sized to retain blood within the lumen until the internal pressure of the lumen increases in response the a finger pressing against a proximal lumen opening.

Abstract: A reconfigurable measuring apparatus includes a first chopper configured to modulate an input signal, and an amplifier configured to amplify an output signal of the first chopper. The reconfigurable measuring apparatus further includes a second chopper configured to demodulate an output signal of the amplifier, and a controller configured to control the first chopper and the second chopper based on a measurement mode.

Abstract: An applanation tonometer is disclosed for providing a measurement of intraocular fluid pressure inside the eye of a patient. The applanation tonometer includes a light-transmitting prism having a cornea contact tip at one end and a cornea alignment aid at the opposite end. The cornea alignment aid enables the patient to advise a vision professional when a light source of the tonometer is properly aligned with his cornea so that intraocular fluid pressure can be accurately measured. A light-blocking baffle is located at the opposite end of the prism, and a thin light-transmitting channel is formed through the baffle to lie on the longitudinal axis of the prism. In a preferred embodiment, the light baffle is at least one opaque disk, and the light-transmitting channel is a clear spot at the center of the opaque disk through which light is transmitted to the patient's cornea.

Abstract: A sensor guide wire for an intravascular measurement of at least one physiological or other variable in a living body may have a proximal region, a distal sensor region, and a tip region. The sensor guide wire may further comprise a sensor element arranged in the sensor region, and comprising a sensor portion for measuring the variable and to generate a sensor signal in response to the variable. Furthermore, a core wire, having a longitudinal axis A, and comprising at least a tip core wire portion, extends essentially along the tip region of the sensor guide wire. The tip core wire portion may further comprise a distal tip. At least a major part of the tip core wire portion is provided with a polymer layer essentially enclosing the at least major part. The distal tip of the tip core wire portion may further comprise an enlargement.

Abstract: An advancement mechanism of a lancing device operates to sequentially advance lancets in a cartridge. The advancement mechanism includes a rotary drive gear assembly with a first gear and a second gear that co-rotate in a first angular direction by operation of an inter-gear unidirectional drive mechanism such as a ratcheting mechanism. A second-gear unidirectional lock mechanism, such as a ratcheting mechanism, locks the second drive gear from co-rotating with the first drive gear in a second opposite angular direction without impeding rotation in the first direction. The second gear directly or indirectly rotationally drives a pinion gear, which rotationally drives a cartridge gear to advance the lancets in indexed increments for use. The first drive gear is rotated in the first and second directions by a rack gear of a translating operating handle. In addition, a rotary-gear cap-displacement mechanism and a rotary-gear charging/actuation mechanism are provided in other embodiments.

Abstract: A system, and a method for its use, provides for placement of a fluid delivery needle into the tail of a laboratory animal. The system includes an animal receiving portion, structure configured to receive, position and restrain a tail of the animal placed in the animal receiving portion and a hollow needle attached to a fluid transfer device. Positioning structure is provided to align the needle and fluid transfer chamber with the restrained tail for proper automated insertion of the needle into a blood vessel within the tail. A lateral actuator operatively connected to the fluid transfer device moves the hollow needle in a forward direction so that it is inserted into the blood vessel of the properly aligned tail. The system can include a computer programmed to automatically perform all of the functions and operate all the components of the system.

Abstract: A device or assortment of devices is provided for measuring temperature and/or other biological parameters, and locating cattle or other types of animals in a remote, continuous and autonomous way. This allows early detection of sickness and other biological states, especially epidemic outbursts or cattle rustling, thus facilitating the early reaction of owners and/or authorities.

Abstract: A biopsy device comprises a body and a needle extending distally from the body. The needle comprises a cannula and a tissue piercing tip that is unitary with the cannula. The tissue piercing tip may be formed by compressing the distal end of the cannula to put two distal cannula portions in apposition with each other. One of the apposed distal cannula portions may be removed. The remaining distal cannula portion may be formed into a blade of the tissue piercing tip. A cutter may be moved relative to the needle to sever samples from tissue protruding through a transverse aperture formed in the cannula. A gap may be provided between the exterior of the cutter and the interior of the cannula, permitting the cutter to be distally vented while a proximal vacuum is communicated to the cutter to transport severed tissue samples proximally through the cutter.

Abstract: A medical device for monitoring physical, chemical, or biological characteristics of an organ, such as the urinary bladder. The medical device may include an elongate member having a proximal end and a distal end. The device may further include an end-effector assembly extending distally from the distal end of the elongate member. The end-effector assembly may also include a plurality of sensing elements for detecting abnormal organ function. Each of the plurality of sensing elements may include one or more of mechanical, visual, chemical, and biological sensors.