Abstract: The invention relates to compounds of formula: ##STR1## in which: R.sub.1 and R.sub.2 denote, independently of one another, a hydrogen atom or alternatively a carbamoyl group of formula: ##STR2## with R'.sub.3 denoting hydrogen or R.sub.3 ; an alkoxycarbonyl group of formula: ##STR3## or an acyl group of formula: ##STR4## in which formulae R.sub.3 denotes an alkyl, alkenyl or cycloalkyl radical; R.sub.3 can also denote an aryl or aralkyl radical; andR denotes a linear or braanched C.sub.1 -C.sub.8 alkyl radical substituted with one or more halogen atoms, and to their use for the treatment and prevention of hair loss and for stimulating its regrowth.

Abstract: The rate and character of mammalian hair growth is altered by topical application to the skin of a composition containing a dermatologically acceptable carrier and an inhibitor of S-adenosylmethionine decarboxylase with or without an ornithine decarboxylase inhibitor.

Abstract: The present invention provides an agent for treating ischemic brain damage comprising 3-sulfamoylmethyl-1,2-benzisoxazole or its alkali metal salt as an active ingredient. This agent can be used for the prevention and/or treatment of cerebral ischemia-induced intracranial diseases or various symptoms associated therewith in mammals including human beings.

Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.

Abstract: A sterile injectable mixture which intensifies and localizes radio frequency thermotherapy; the injectable mixture contains finely ground ferrite particles in a viscid aqueous suspension, the ferrite being matched for maximum radio frequency absorption at a specific frequency. A chemotherapeutic agent, a surfactant and a bioacceptable hydrophic colloid are also contained in the mixture.

Abstract: Aqueous stable injectable formulations containing the sodium salt of naproxen, stabilizing agents and polyhydroxylic alcohols, packaged in containers made up of boxes of polystyrene or of an equivalent material covered with films which absorb the light radiations.

Abstract: A method of treating cocaine addiction by administering to a patient in need thereof, an anti-cocaine addicting effective amount of a calcium channel blocking agent.

Abstract: We have found a new and useful process to generate peroxy acid sanitizing and bleaching compositions at the point-of-use, the process comprising introducing hydrogen peroxide and a carboxylic acid into a reactor at about 0.1 to 10 moles of hydrogen peroxide per mole of acid, and contacting the hydrogen peroxide and carboxylic acid in the presence of a sulfonic acid resin and in the substantial abssence of active metal ions which forms an aqueous peroxy acid composition at a concentration from about up to 20 wt %. Using this process, warewashing, laundry sanitizing and bleach, and hard surface sanitizing compositions can be produced.

Abstract: The treatment of atherosclerosis by administration of pure MgNa.sub.2 EDTA to a patient to favorably influence one or more of the multiple stages in the complex pathophysiology of the disease.

Abstract: The present invention comprises an amazingly effective method for the treatment, prevention and reversal of diet-induced high fat or alcohol-induced tissue-degernative conditions. More specifically, the present invention involves the discovery that pentoxidfylline, when administered in vivo will: (1) successfully treat diet-induced fatty liver conditions; (2) successfully treat atheromatous lesions, particularly those caused by ingestion of high levels of dietary fat and/or hypercholesterolemia; and (3) successfully treat conditions of fatty liver degeneration caused by chronic ingestion of ethanol or of toxic doses of various chlorinated hydrocarbons.

Abstract: Preparation and use of a composition of alpha-chymotrypsin in either a physiologically suitable solution or suspension medium, in a dilution of 1:10,000 to 1:30,000, corresponding to a ratio of amounts of 1 milligram of alpha-chymotrypsin to 10 to 30 milliliters of the solution medium, or in a dispersion, by volume, of preferably 1:15,000 to 1:20,000 of the alpha-chymotrypsin to the suspension medium, for the treatment and cleaning of the posterior lens capsule left behind in an extracapsular cataract operation. The composition, in its final application solution or dispersion form contains an amount of a viscoelastic substance adapted for intraocular or intraorbital surgical operations and suitable for combatting or preventing unwanted further dilution of the alpha-chymotrypsin, regardless of the amount of fluids either present or subsequently collected in the eye during the posterior lens cleaning operation.

Abstract: A method is provided for attenuating the intoxicating effects of ethyl alcohol in a patient, by administering to a patient in need thereof, an alpha-2 adrenoceptor antagonist compound. Two preferred compounds useful in the present invention, each being a highly potent and selective alpha-2 adrenoceptor antagonist, are atipamezole and idazoxan.

Abstract: An immunoadjuvant capable of producing secondary antibody responses as great as 50 to 60% of those obtained using Freund's complete adjuvant (FCA) which responses decline at a slow rate while not showing the disadvantages associated with FCA. The immunoadjuvant comprises an immunoadjuvant oil such as a mineral oil, squalene or squalane and a polycationic polyelectrolyte immunoadjuvant such as DEAE-Dextran or polyethyleneimine. The immunoadjuvant preferably comprises an emulsion having the oil in one phase and an aqueous solution of the polycationic polyelectrolyte in the other phases. Such immunoadjuvants are used with antigens, such as conjugates of hormones, e.g. luteinizing hormone releasing hormone, and an immunogenic protein.

Abstract: The invention is directed to cosmetic powder compositions containing containing esters, a gellant, and polyvinylidene copolymer. These cosmetic compositions are useful for blushes, eyeshadow, and so on.

Abstract: The craving for cocaine and use of cocaine among users may be reduced by administration of valproic acid. Cocaine-usage is effectively treated with valproic acid administration.

Abstract: In accordance with the present invention, there is now provided a method for the diagnosis of amyloidosis, which comprises subjecting a protein sample such as serum, cerebrospinal fluid or brain tissues containing amyloid deposits obtained from a patient suspected of suffering from an amyloidosis related disease to measurement of the amount of ubiquitin in said sample, and comparing the resulting amount with the amount of ubiquitin in a normal healthy patient. In a second aspect of the present invention, there is provided a method for the diagnosis of Alzheimer's disease, which comprises subjecting a protein sample obtained from the brain extract or cerebrospinal fluid of a patient suspected of suffering from Alzheimer's disease to measurement of the amount of ubiquitin, and comparing the resulting amount with the amount of ubiquitin in a normal healthy patient.

Abstract: The present invention provides a method for treating and/or reducing ischemic reperfusion injury. To this end, in embodiment, a method for treating and/or reducing reperfusion injury is provided comprising the step of administering to a patient in danger of reperfusion injury a therapeutically effective amount of L-2-oxothiazolidine-4-carboxylic acid. In an embodiment, a method is provided for limiting an expected ischemic reperfusion injury comprising the step of administering prior to an expected ischemic event a therapeutically effective amount of L-2-oxothiazolidine-4-carboxylic acid. In a further embodiment of the present invention, a method is provided for limiting ischemic reperfusion injury comprising the step of administering to a patient after the onset of an ischemic event a therapeutically effective amount of L-2-oxothiazolidine-4-carboxylic acid.

Abstract: Salts of azelastine with acetic acid, gluconic acid, lactic acid or malic acid.

Abstract: A method for treating alcoholism. The alcohol-drinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain.

Abstract: This invention concerns novel methods employing compositions containing as an active antioxidant or antiinflammatory agent the amino acid methionine, and/or one or more related compounds including certain metabolic precursor compounds, for treating or inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response in a subject. The compounds include the methionine hydroxy analogs, as well as compounds having the structural formula I: ##STR1## and pharmaceutically acceptable N-(mono- and di-carboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer from 1 to 3.