Abstract: A water savings system and method for reducing the amount of water needed for adiabatic cooling including the use of a softener and a reverse osmosis device, in which tap water, softened if necessary, is delivered to a reverse osmosis device and softened water alone, reverse osmosis reject water, or softened water combined with reverse osmosis reject water is delivered to spray nozzles for cooling, and reverse osmosis pure water is stored and used periodically to flush the coils to inhibit and/or prevent corrosion from dissolved salts and other solids in the spray water.

Abstract: A dialysis method to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments is disclosed. The method includes determining, via a base unit controller, whether a peritoneal dialysis treatment or an extracorporeal blood treatment is to be performed. If the peritoneal dialysis treatment is to be performed, the method includes operating first software instructions that cause a base unit to use a first fluid stored in a fluid container. If the extracorporeal blood treatment is to be performed, the method includes operating second software instructions that cause the base unit to use a second, different fluid from an online source and selectively move the second, different fluid to a blood treatment unit for use in the extracorporeal blood treatment. The blood treatment unit is operable with the base unit to perform the extracorporeal blood treatment on a patient.

Abstract: A system and method are provided for separating previously-collected whole blood into a red blood cell fraction and a plasma fraction by which the container of previously-collected whole blood is determined to be empty based on using the combination of the measured gross weight of the container and a calculated fluid flow rate from the container, based on weigh scale feedback. Upon detection of the empty container, flow from the container is stopped.

Abstract: Provided is a porous hollow fiber membrane made of a thermoplastic resin, wherein a membrane thickness is 0.050 mm or larger and 0.25 mm or smaller, and when a strength coefficient is defined as K=(compressive strength)/((membrane thickness)/(inside diameter/2))3, K=1.7 or more.

Abstract: The disclosure relates to processes, related polyacid polymers, and related articles for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface, in particular polyacid polymers including repeating units with a pendent metal-binding ligand or star polyacid polymers. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process, for example without a need to derivatize an adsorbed polyacid layer to impart metal-binding ligand functionality thereto. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization.

Abstract: An aqueous stream cleaning system including a circulation pump to receive a waste fluid and/or a concentrated liquid bottoms stream, and expel a circulation stream. The aqueous stream cleaning system can also include a primary heat exchanger to receive the circulation stream from the circulation pump. The primary heat exchanger can have a plurality of heat exchange plates that define an internal surface area for heat transfer from a distillate stream to the circulation stream to produce a cooled distillate stream and a heated circulation stream. The plurality of heat exchange plates can be spaced to facilitate free flow of solids in the circulation stream between the plurality of heat exchange plates. A mass flow rate and pressure of the circulation stream can be configured to minimize build-up of solids in the primary heat exchanger. The aqueous stream cleaning system can further include an evaporation unit to receive the heated circulation stream from the primary heat exchanger.

Abstract: An interface device between external equipment and at least a venous tube for transferring fluid to a patient, the interface device having at least a first port adapted to be connected to an outlet port of the external equipment; and a venous port carried by a stator of the interface device in order to inject the fluid into the venous tube. The interface device includes a third port, the first port and the third port being carried by a movable assembly that is movable relative to the stator, the interface device being arranged to pass from any one of its configurations to another one of its configurations by the movable assembly moving relative to the stator.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: The invention relates to devices, systems, and methods for precision recharging of sorbent materials in a sorbent module. The devices, systems, and methods use manufacturing characteristics of the sorbent module to set recharge parameters used in recharging the sorbent material.

Abstract: A system for monitoring percentage change in blood volume (?BV %) during dialysis treatment includes a sensor device configured to obtain hematocrit (Hct)-related measurements based on detecting light which has passed through extracorporeal blood of a patient undergoing the dialysis treatment; one or more controllers configured to: determine Hct values based on the Hct-related measurements obtained by the sensor device; determine ?BV % values based on the determined Hct values; and generate a GUI having a ?BV % plot based on the determined ?BV % values; and a display device having a display configured to display the GUI having the ?BV % plot. Zone indicators are provided on the display to distinguish between a first zone corresponding to a first ?BV % profile, a second zone corresponding to a second ?BV % profile, and a third zone corresponding to a third ?BV % profile.

Abstract: This disclosure relates to dialysis systems and methods. In some implementations, a dialysis system includes a dialysis machine with a fluid line and a drain line, a blood line set configured to be connected to the dialysis machine, and a drain apparatus coupled to the dialysis machine. The drain apparatus includes a chamber configured to receive an end of a patient line of the blood line set, an inlet line, an outlet line, and a valve. The inlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the fluid line of the dialysis machine. The outlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the drain line of the dialysis machine. The valve is configured to control flow of fluid through the outlet line.

Abstract: A centrifugal separation device of a blood component collection system, which is one form of a biological component collection system, performs a pressure release step of stopping a collection and returning pump at the end of a returning operation, and releasing a positive pressure inside a filter structural member, a clamp closure step of closing an inlet flow passage and an outlet flow passage of the filter structural member, and a collection operation starting step of starting a subsequent collection operation.

Abstract: An extracorporeal photopheresis system includes a separator with a disposable fluid circuit including a treatment container, an irradiation device configured to treat the contents of the treatment container, and a controller configured to control the system to perform a procedure including drawing anticoagulated whole blood into the fluid circuit from a blood source and returning to the blood source a treated target cell component, a portion of a red blood cell component remaining in the fluid circuit, and/or a portion of a plasma component remaining in the fluid circuit. The controller is further configured to estimate an end-of-procedure fluid balance estimated based on manual or automatic inputs including a patient body weight associated with the blood source and a total blood volume of the blood source, indicate the fluid balance to an operator, and receive one or more changes that affect the fluid balance after indicating the fluid balance.

Abstract: A dialysis system may include a blood circuit, a cassette, a subsystem having a processor, a sensor, and a blood pumping mechanism, a housing in which the subsystem is arranged, a movable support arranged in the housing and configured to hold the sensor and/or the blood pumping mechanism of the subsystem, a cassette holder configured to removably receive the cassette, and a loading system. The loading system may be configured to move the movable support, e.g. by an axial movement, to a first position and to a second position relatively to the housing while the cassette holder is fixedly arranged in the housing. The loading system may have an electric motor controlled by the processor, a drive assembly coupled to the electric motor, and a guiding assembly configured to cooperate with the drive assembly.

Abstract: A blood component collection cassette that can trap a substance where blood components coagulate by using a simple and economical configuration, and a manufacturing method of the blood component collection cassette are provided. A blood component collection cassette (28) includes a cassette main body (40) where a flow path (42) is formed and is configured to be mountable to a centrifugal separation device (14). The cassette main body (40) has a first sheet (40a) and a second sheet (40b) which are formed of a soft material. The flow path (42) is formed between the first sheet (40a) and the second sheet (40b). A filter member (60) for trapping a substance where blood components coagulate is arranged on the flow path (42) in the cassette main body (40).

Abstract: A method for regenerating an adsorber which has a porous body and does not have an enzyme includes a dialysis step, in which the adsorber is connected to a dialysate circulation unit to cause uremic substances within a dialysate to be adsorbed onto the adsorber, and a regenerating step, in which the uremic substances which are adsorbed on the adsorber are desorbed by regenerating water that flows in a regenerating water flow unit. A dialysis system is equipped with the dialysate circulation unit, the adsorber, which is connected to the dialysate circulation unit, and the regenerating water flow unit. The regenerating water flow unit is connectable to the adsorber.

Abstract: A dialysis device (100) comprises: a dialyzer for exchange of substances between a blood flow and a dialysate flow in a dialysis area (106) of the dialyzer, wherein the dialyzer comprises a dialyzer membrane (110) for passing toxins in the blood flow to the dialysate flow through pores (112) of the dialyzer membrane (110); and a capacitively coupled generator (120) for generating electromagnetic fields in the dialysis area (106) for loosening electrostatic bonds between toxins and proteins in the blood flow, wherein the generator (120) is capacitively coupled to the blood flow and to the dialysate flow on opposite sides of the dialyzer membrane, and wherein the dialysate membrane (110) is formed of a material having lower conductance than blood and dialysate such that a large electromagnetic field strength is provided across the pores (112) of the dialyzer membrane (110).

Abstract: A blood treatment machine includes a patient comfort feedback mechanism configured to be adjusted by a patient to indicate comfort levels of the patient. The machine is configured to adjust one or more treatment parameters based on the patient feedback.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for receiving a conductivity or sodium concentration set point for the dialysis fluid and for calculating a mass transport of a substance at an instant t of a treatment session based on said set value of the parameter for the dialysis fluid in the dialysis supply line (8).