Abstract: A pressure pulsation dampener for use in connection with positive displacement reciprocating piston pumps comprising a spherical pressure vessel having opposed inlet and outlet ports arranged along a diametral line of the vessel sphere and having a generally cylindrical flexible tubular member forming part of a replaceable cartridge disposed within the interior chamber of the spherical pressure vessel. The liquid volume capacity of the spherical pressure vessel is sufficient to reduce to the flow velocity of the liquid entering the vessel by approximately 85%. A flexible elastomeric tubular member is provided with encapsulated longitudinally extending reinforcing cords which are of a generally curved shaped and of a length longer than the length of the flexible member. Upon inflation of the flexible member the cords ultimately come under tension to limit the expansion or distention of the flexible member and to absorb the stress imposed on the flexible member under the maximum distended condition.