Abstract: A wheel hub for a two-wheeled vehicle, such as a bicycle, includes a quick clamping device for securing the hub axle in the fork of a bicycle frame. The device includes a clamping unit at each end of the hub axle. Each clamping unit contains an adjusting nut screwed onto one end of the axle, a thrust ring inboard of the nut, and a pivotally movable clamping member with eccentric cams positioned between facing surfaces on the nut and thrust ring. By pivoting the clamping member the position of the cams is changed for displacing the clamping device from the release position to the locking position where the hub axle can be tightly clamped in the fork without any special shaping of the axle.