Abstract: This invention provides a novel anti-microbial system suitable for formulation in a wide variety of ophthalmic solutions. In particular the composition comprises an antimicrobial peptide that is an indolicidin and a buffer compatible with application to a mammalian eye, wherein the buffer is a Good's buffer or the buffer has a halide ion concentration less than 0.85 wt %. The compositions are useful for storing, cleaning, or disinfecting a contact lens. In particular the compositions are self-preserving upon lengthy storage, effective in cleaning and sterilizing contact lenses upon exposure of the lens to the composition, do not require the need for physical or thermal treatment of the lens and enable the immediate application of the lens to the eye without the need for neutralization, deactivation or washing.
Type:
Grant
Filed:
May 25, 1999
Date of Patent:
November 19, 2002
Assignee:
The Regents of the University of California
Abstract: Pharmaceutical compositions which are useful for the treatment of cancer or illnesses which arise due to an abnormally elevated cell proliferation comprise acyl derivatives of aromatic aldehydes, especially arylidene diesters and .alpha.-alkoxyarylidene esters of general formula (I).
Type:
Grant
Filed:
October 4, 1996
Date of Patent:
December 26, 2000
Assignee:
Norsk Hydro A.S.
Inventors:
Erik Olai Pettersen, Rolf Olaf Larsen, John Michael Dornish, Bernt B.o slashed.rretzen, Reidar Oftebro, Thomas Ramdahl, Vidar Moen
Abstract: A carbonic acid ester is produced by reacting an alcohol with carbon monoxide and oxygen in the presence of a catalyst comprising a cupric salt of a weak acid and/or a cupric halide and an alkaline earth metal salt of a weak acid and/or an alkaline earth metal halide.