Abstract: Pharmaceutical compositions especially for internal application which create lyotropic liquid crystals when in contact with aqueous phase. The pharmaceutical compositions consist of:
A hydrophobic active ingredient with immunomodulatory effect from a group of N-methylated cyclic undecapeptides or macrolide antibiotics, in quantity 1-35 weight % in a carrier medium containing
B at least one absorption promoter allowing for contact of the drug with a biological membrane or passing of the drug through in quantity 1-40 weight %,
C nonlipidic vehicle containing at lest one of the below mentioned substances:
C1 surfactant or mixed surfactant with HLB>9, in quantity 1-80 weight %
C2 lipophilic solvent from group of higher fatty alcohols in quantity 1-30 weight %
C3 at least one cosurfactant in quantity 1-50 weight %,
while a ratio among the individual components of the product is A:B:C=1:0.5-4:5-8.
Type:
Grant
Filed:
September 12, 1997
Date of Patent:
June 11, 2002
Assignee:
Galena AS
Inventors:
Tomas Andrysek, Milan Stuchlik, Vladimir Matha, Alexander Jegorov, Ales Husek, Josef Stuchlik
Abstract: This invention has for its object to provide a pharmaceutical composition for the prevention and/or treatment of hyperphosphatemia and secondary hyperparathyroidism, inclusive of their accessory disorders and symptoms.
The object is accomplished by provision of a pharmaceutical composition comprising an adenosine antagonist as an active ingredient.
Abstract: Antibacterial and antifungal polyacetal resin compositions include a polyacetal base resin, and an antibacterial and/or antifungal effective amount between about 0.1 to about 5 parts by weight, per 100 parts by weight of the polyacetal base resin, of at least one antibacterial and antifungal agent which contains a metal ion selected from among silver, copper and zinc ions.
Abstract: An aqueous, alcoholic or hydroalcholic composition containing one or more oligomers or prepolymers that are polymerized in-situ, while the oligomer(s) is in contact with the hair, for in-situ formation (polymerization) of a polymer. The oligomer compositions contain essentially no toxic, hazardous or harmful monomer(s), such as resorcinol.