Patents Examined by Elizabeth Slobodyansley
  • Recombinant crab collagenase
    Patent number: 5747322
    Abstract: An isolated sequence is provided that encodes crab procollagenase (Seq ID NO 5) that upon cleaving off the 29 amino acid propeptide (Seq ID NO 6) transforms into an active collagenase (Seq ID NO 4). The procollagenase has the MW of about 26.6 kD and the mature collagenase has a MW of 23.5 kD. Procollagenase mutated at positions 201 and 235 is also provided. A storage-stabilized composition providing long-term, shelf-stable protease that can be readily activated when collagenolytic activity is desired is disclosed.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: May 5, 1998
    Assignee: The Regents of the University of California
    Inventors: Charles S. Craik, Christopher A. Tsu