Patents Examined by Elizabeth Weimar
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Patent number: 5578567Abstract: A pharmaceutical composition adapted for nasal administration and comprising hPTH or a N-terminal fragment thereof. Preferred carriers are optionally coated celluloses.Type: GrantFiled: August 25, 1993Date of Patent: November 26, 1996Assignee: Sandoz Ltd.Inventors: Fran.cedilla.ois Cardinaux, Christine Oechslein, Andreas Rummelt
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Patent number: 4794080Abstract: A simultaneous sequential anaerobic fermentation process for the in vitro production of propionic and acetic acids is disclosed. The process comprises employing an obligatory two-component co-culture which maintains a relatively constant ratio of species populations over multiple passages. A first co-culture component is a Lactobacillus or Streptococcus which homofermentatively converts the hexose to lactic acid. A second microorganism in the co-culture is a Veillonella which is metabolically incapable of assimillating the hexose and converts the lactic acid product to propionic and acetic acids. The co-culture is inoculated into a nutrient growth feedstock such as whole whey or a clarified dairy whey lactose permeate which contains a metabolizable source of a hexose such as glucose, lactose or sucrose.Type: GrantFiled: April 16, 1984Date of Patent: December 27, 1988Assignee: IGENE Biotechnology, Inc.Inventors: Thomas D. Mays, Pamela N. Fornili
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Patent number: 4792523Abstract: The invention concerns positive retroregulatory elements, which when ligated to selected DNA sequences coding for a gene product, enhance the expression of the gene product. Plasmids carrying the positive retroregulatory element ligated to selected DNA sequence and cells transformed by such plasmids are provided AND claimed. In addition, the invention relates to a method for enhancing expression of a gene product by ligating a positive retroregulatory element to a selected DNA sequence expressionable for a desired gene product.Type: GrantFiled: August 31, 1984Date of Patent: December 20, 1988Assignee: Cetus CorporationInventors: Hing C. Wong, Shing Chang
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Patent number: 4791058Abstract: It has now been found that grape pomace can be employed as a substrate for citric acid production using Aspergillus niger as the fermentation agent.Type: GrantFiled: May 10, 1985Date of Patent: December 13, 1988Assignee: Cornell Research Foundation, Inc.Inventor: Yong D. Hang
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Patent number: 4784950Abstract: Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIa. The proteins are produced by mammalian host cells which have been stably transfected with a DNA construct containing a nucleotide sequence which codes at least partially for either Factor VII. The nucleotide sequence comprises a first nucleotide sequence encoding a calcium binding domain, joined to a second nucleotide sequence positioned downstream of the first sequence. In particular, the first nucleotide sequence may be derived from a genomic clone or cDNA clone of Factor VII. The second sequence encodes a catalytic domain for the serine protease activity of Factor VIIA. The joined sequences code for proteins having substantially the same biological activity for blood coagulation as Factor VIIa.Type: GrantFiled: December 16, 1986Date of Patent: November 15, 1988Assignee: ZymoGenetics, Inc.Inventors: Frederick S. Hagen, Mark J. Murray, Sharon J. Busby, Kathleen L. Berkner, Margaret Y. Insley, Richard G. Woodbury, Charles L. Gray
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Patent number: 4783403Abstract: L-phenylalanine is produced by using a microorganism belonging to the species Citrobacter freundii, Erwinia herbicola, Enterobacter cloacae, Klebsiella oxytoca, Salmonella typhimurium, Bacillus cereus, Flavobacterium suaveolens, Serratia marcescens, Pseudomonas putida, Enterobacter cloacae, Proteus mirabilis, Paracoccus denitrificans, Arthrobacter globiformis, Bacillus sphaericus, Corynebacterium hydrocarboclastus, Kluyvera micum or Microbacterium ammoniaphilum and having the ability to convert phenylpyruvic acid into L-phenylalanine in the presence of an amino group donor; or fumaric acid and ammonium ion or urea.Type: GrantFiled: February 1, 1985Date of Patent: November 8, 1988Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kazumi Araki, Toshitsugu Ozeki, Yukiyoshi Ito, Shuichi Ishino, Hideharu Anazawa, Shigeru Kamimori
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Patent number: 4780414Abstract: A novel mutant microorganism Streptococcus zooepidemicus HA-116 ATCC 39920, has been produced. The microorganism produces large amounts of high molecular weight hyaluronic acid. The invention provides a method of obtaining such microorganisms.The invention also concerns a method of obtaining sodium hyaluronate which comprises growing with vigorous agitation a microorganism of the genus Streptococcus under appropriate conditions in a suitable nutrient medium containing a sugar component as a carbon source. The sugar component is present in a substantially constant concentration between 0.2 and 10 grams per liter. The medium has a substantially constant pH between about 6.0 and 7.5 and includes a substantially constant magnesium ion concentration above 0.05 grams per liter. The sodium hyaluronate excreted into the medium by the organism is purified using methods involving precipation, redissolving and reprecipating the hyaluronate.Type: GrantFiled: January 9, 1986Date of Patent: October 25, 1988Assignee: Bio-Technology General Corp.Inventors: Abraham Nimrod, Benjamin Greenman, Dov Kanner, Moshe Landsberg, Yaffa Beck
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Patent number: 4780415Abstract: A method and apparatus for carrying out a degradation in an anaerobic medium, such as a methanogenesis, of organic products, by-products or waste from human, animal and/or plant origin, involving feeding said products to be degraded into a closed fermentation vessel, forcing said products to flow in a direction of circulation within said vessel and recovering the gas produced called biogas evolved above said body of degraded products, with the feeding and/or discharge of the products performed pneumatically, preferably through pneumatic thrust and, according to a preferred embodiment, by injection of gas, preferably biogas. A further improvement comprises using the biogas produced for homogenizing said body of products contained within said vessel, the pressure of injection being in relation to the actual density of the products, in the injection related section.Type: GrantFiled: March 19, 1984Date of Patent: October 25, 1988Assignees: Gilbert Ducellier, Andre Pavia, Union Industrielle et d'Entreprise, ValorgaInventors: Gilbert Ducellier, Andre Pavia
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Patent number: 4774184Abstract: The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.Type: GrantFiled: August 14, 1985Date of Patent: September 27, 1988Assignee: American Cyanamid CompanyInventors: Taikwang M. Lee, Donald B. Borders, Joseph J. Goodman, Raymond T. Testa, William M. Maiese, David P. Labeda
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Patent number: 4774179Abstract: A process for preparing a 7-aminocephalosporanic acid compound which comprises treating a cephalosporin C compound with an enzyme-producing microorganism belonging to the genus Pseudomonas or a material obtained by subjecting the microorganism to chemical and/or physical treatment. A direct hydrolysis of the cephalosporin C compound into the 7-aminocephalosporanic acid compound and D-.alpha.-aminoadipic acid can be attained by the microorganism or material.Type: GrantFiled: July 9, 1985Date of Patent: September 27, 1988Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Shigeaki Ichikawa, Keizou Yamamoto, Kenji Matsuyama
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Patent number: 4772556Abstract: The present invention relates to a stable, allopolyploid, somatic fusion product useful in the fermentation arts and especially in the production of fuel alcohols. More particularly, the present invention relates to a novel allopolyploid yeast strain, Saccharomyces diastaticus NCYC 1460, which is the product of the spheroplast fusion of:(a) a hybrid, diploid strain of Sacch. diastaticus; and(b) a fusion partner which is a polyploid brewing yeast strain of the species Saccharomyces uvarum (carlsbergensis).The fusion product of the present invention is capable of an enhanced rate of fermentation and a generally higher degree of final attenuation than is typical of either of the fusion partners. Moreover the fusion product also evidences enhanced osmo- and thermo-tolerances and its multiple, non-allelic DEX gene complement renders the organism well suited to the fermentation of substrates containing dextrins and oligosaccharides.Type: GrantFiled: July 14, 1986Date of Patent: September 20, 1988Assignee: Labatt Brewing Company, LimitedInventors: Graham G. Stewart, Ingeborg Russell, Chandrakant J. Panchal
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Patent number: 4771131Abstract: The toxin gene encoding a protein toxic to beetles of the order Coleoptera, named M-7, has been cloned and expressed. M-7 is a novel Bacillus thuringiensis strain which has been deposited with a recognized culture repository. The microbe is now known as B. thuringiensis strain san diego.Type: GrantFiled: June 16, 1986Date of Patent: September 13, 1988Assignee: Mycogen CorporationInventors: Corinna Herrnstadt, Edward Wilcox
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Patent number: 4769317Abstract: Procedures are disclosed for eliminating immune competent cells from a population of human epidermal cells. The cells free of immune competent cells are used for growing tissue sheets suitable for transplantation to recipients unrelated to the donor.Type: GrantFiled: June 14, 1983Date of Patent: September 6, 1988Inventor: John M. Hefton
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Patent number: 4767705Abstract: Apple pomace, the residue left from juice extraction, can be employed as a substrate for citric acid production using Aspergillus niger as the fermentation agent.Type: GrantFiled: November 19, 1984Date of Patent: August 30, 1988Assignee: Cornell Research Foundation, Inc.Inventor: Yong D. Hang
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Patent number: 4766076Abstract: The invention comprises a novel starter medium for the commercial propagation of acid producing bacteria, such as those used in food fermentation processes. The compositions are unique in that they contain a highly effective buffering ingredient which is a sodium, potassium, or ammonium salt or double salt of a linear aliphatic dibasic acid having from three to seven carbon atoms. The salts are present in an amount sufficient to maintain the growth medium at pH levels of about 5.0 or above during the time in which the bacteria are multiplying in the culture medium. Disodium or diammonium succinate, glutarate, or adipate are materials which have been found to be particularly effective. These may be used in combination with nutrients such as whey, whey permeate, nonfat dried milk, yeast extract, and diammonium phosphate. The addition of trace quantities of certain metals promotes the growth and activity of the acid producing bacteria.Type: GrantFiled: June 19, 1984Date of Patent: August 23, 1988Assignee: The State of Oregon acting by and through the Oregon State Board of Higher Education on behalf of Oregon State UniversityInventors: William E. Sandine, James W. Ayres
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Patent number: 4764389Abstract: A fruit ripening system wherein a continuous inflow of fresh air and ethylene gas is provided into a fruit ripening chamber in correct proportions to form a fruit ripening gas mixture that will predictably ripen fruit in a very short period of time, regardless of the previous state of ripening of the fruit. At the same time, the ripening chamber is continuously purged of carbon dioxide that is a byproduct of the ripening process so that during the ripening process a concentration of carbon dioxide sufficient to materially impede the ripening process is never allowed to build up. Critical parameters are defined for ripening temperature, the minimum ethylene gas concentration, time of exposure to the ethylene gas, and purging of carbon dioxide.Type: GrantFiled: October 5, 1987Date of Patent: August 16, 1988Assignee: LaBarge Universal Ripener, Inc.Inventor: Louis P. LaBarge
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Patent number: 4764471Abstract: An improved bioreactor and process for continuously propagating microorganisms, such as yeast, wherein the culture medium is purified in contact with a spirally-wound ultrafiltration membrane and then passed through the outer surfaces of a tubular membrane material for further purification before contact with microorganisms flowing in the interior of the tubular membrane material.Type: GrantFiled: January 4, 1984Date of Patent: August 16, 1988Assignee: Nabisco Brands, Inc.Inventor: Michael S. Ripka
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Patent number: 4764372Abstract: The subject invention concerns a novel and useful insecticide with activity against insect pests of the order Coleoptera. Pests in this order do heavy damage to crops, e.g., corn. The insecticide of the subject invention is a novel B. thuringiensis microbe given the specie designation M-7. The spores or crystal of this microbe are useful to control Coleoptera pests in various environments.Type: GrantFiled: March 22, 1985Date of Patent: August 16, 1988Assignee: Mycogen CorporationInventors: Corinna Herrnstadt, George G. Soares, Jr.
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Patent number: 4759471Abstract: A process for preparing fruit juice beverages capable of being sold in cups via dispensing vending machines which comprises the steps of subjecting a fruit juice containing solid matter to milling, deaeration, homogenization and optional pasteurization, the milled juice being dispensed through a flow quantity control means substantially without clogging at the flow quantity control means.Type: GrantFiled: July 16, 1985Date of Patent: July 26, 1988Assignee: Kirin Beer Kabushiki KaishaInventor: Yutaka Takahashi
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Patent number: 4759941Abstract: A hopping material useful as a kettle additive in preparing anactinic malt beverages is prepared by a method which includes first forming an aqueous suspension of crude hops, containing alpha acids and cellulosic material and alkali hydroxide and an alkali borohydride. The suspension, which has a pH above about 10.5, is heated to isomerize and reduce the alpha acids initially present in the hops. The pH is lowered to about 2 to convert the reduced iso-alpha acids to their free acid forms so that they are adsorbed on cellulosic hop material in the reaction mixture. The cellulosic material which now contains the free isomerized and reduced alpha acids is isolated and is useful as an anactinic kettle additive which can be stored for prolonged periods with no decomposition.Type: GrantFiled: April 30, 1985Date of Patent: July 26, 1988Assignee: Miller Brewing CompanyInventors: Etzer Chicoye, Walter H. Fly, Henry Goldstein